ChemicalBook > CAS DataBase List > 3-iodo-5-(trifluoromethyl)-2-pyridinylamine

3-iodo-5-(trifluoromethyl)-2-pyridinylamine

Product Name: 3-iodo-5-(trifluoromethyl)-2-pyridinylamine
CAS No.: 211308-82-6
Chemical Name: 3-iodo-5-(trifluoromethyl)-2-pyridinylamine
Synonyms: 3-IODO-5-(TRIFLUOROMETHYL)PYRIDIN-2-AMINE;3-iodo-5-(trifluoromethyl)pyridine-2-amine;-iodo-5-(trifluoromethyl)-2-pyridinylamine;3-Iodo-5-trifluoroMethyl-pyridin-2-ylaMine;3-iodo-5-(trifluoromethyl)-2-pyridinylamine;2-Pyridinamine, 3-iodo-5-(trifluoromethyl)-;2-Amino-3-iodo-5-(trifluoromethyl)-pyridine;3-Iodo-5-(trifluoromethyl)-2-pyridinylamine(en);1H-Imidazole-4-carboxylicacid,1-(7-bromophenyl)-;3-IODO-5-TRIFLUOROMETHYL-PYRIDIN-2-YLAMINE (NOT RESTRICTED/P - ROHIBITED) (LAB RESEARCH CHEMICAL)
CBNumber: CB81526574
Molecular Formula: C6H4F3IN2
Formula Weight: 288.01
MOL File: 211308-82-6.mol

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3-iodo-5-(trifluoromethyl)-2-pyridinylamine Property

Melting point:: 97-98°
Boiling point:: 269.4±40.0 °C(Predicted)
Density: 2.049±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 2.15±0.49(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000574
Product name: 3-Iodo-5-(trifluoromethyl)pyridin-2-amine
Purity: Aldrich
Packaging: 1g
Price: $761
Updated: 2023/06/20

TRC

Product number: I737085
Product name: 3-Iodo-5-(trifluoromethyl)pyridin-2-amine
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 0788AB
Product name: 2-Amino-3-iodo-5-(trifluoromethyl)pyridine
Packaging: 1g
Price: $144
Updated: 2021/12/16

Matrix Scientific

Product number: 046925
Product name: 3-Iodo-5-(trifluoromethyl)-2-pyridinylamine
Purity: >95%
Packaging: 1g
Price: $155
Updated: 2021/12/16

Apolloscientific

Product number: PC200189
Product name: 2-Amino-3-iodo-5-(trifluoromethyl)pyridine
Packaging: 5g
Price: $322
Updated: 2021/12/16

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3-iodo-5-(trifluoromethyl)-2-pyridinylamine Chemical Properties,Usage,Production

Synthesis

74784-70-6

211308-82-6

Concentrated sulfuric acid (5 mL), periodate (26 g, 123 mmol) and iodine (62 g, 246 mmol) were sequentially added to a stirred solution of 5-(trifluoromethyl)pyridin-2-amine (100 g, 617 mmol) in acetic acid (1 L) under argon protection and at room temperature. The reaction mixture was heated to 80 °C and stirred continuously for 16 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the complete consumption of the raw materials, the reaction mixture was cooled to 0 °C and alkalized with sodium hydroxide solution (200 mL) to precipitate the solid product. The solid was collected by filtration and concentrated under vacuum to afford the target compound 3-iodo-5-(trifluoromethyl)pyridin-2-amine (120 g, 67% yield) as an off-white solid. The product was characterized by 1H NMR (DMSO-d6, 500 MHz): δ 8.27 (s, 1H), 8.16 (s, 1H), 6.87 (brs, 2H); TLC conditions: 10% ethyl acetate/hexane (Rf 0.4).

References

[1] Patent: WO2008/79346, 2008, A1. Location in patent: Page/Page column 58
[2] Patent: WO2017/31325, 2017, A1. Location in patent: Paragraph 0522
[3] Patent: WO2017/133667, 2017, A1. Location in patent: Page/Page column 116; 117
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 3, p. 1160 - 1170
[5] Patent: US2005/277681, 2005, A1. Location in patent: Page/Page column 26

3-iodo-5-(trifluoromethyl)-2-pyridinylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-iodo-5-(trifluoromethyl)-2-pyridinylamine manufacturers

Career Henan Chemical Co

Product: 3-Iodo-5-(trifluoromethyl)pyridin-2-amine 211308-82-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-30

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211308-82-6

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