ChemicalBook > CAS DataBase List > 2-AMINO-5-IODO-3-NITROPYRIDINE

2-AMINO-5-IODO-3-NITROPYRIDINE

Product Name
2-AMINO-5-IODO-3-NITROPYRIDINE
CAS No.
25391-57-5
Chemical Name
2-AMINO-5-IODO-3-NITROPYRIDINE
Synonyms
Zinc04202918;5-iodo-3-nitro-2-pyridinamine;5-iodo-3-nitropyridin-2-aMine;2-PYRIDINAMINE,5-IODO-3-NITRO;2-Amino-3-nitro-5-iodopyridine;2-AMINO-5-IODO-3-NITROPYRIDINE;5-IODO-3-NITRO-PYRIDIN-2-YLAMINE;2-Amino-5-iodo-3-nitropyridine 95+%;2-AMINO-5-IODO-3-NITROPYRIDINE ISO 9001：2015 REACH
CBNumber
CB3203020
Molecular Formula
C5H4IN3O2
Formula Weight
265.01
MOL File
25391-57-5.mol
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2-AMINO-5-IODO-3-NITROPYRIDINE Property

Melting point:
215-219 °C (lit.)
Boiling point:
365.4±42.0 °C(Predicted)
Density 
2.229±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
solid
pka
0.41±0.49(Predicted)
Appearance
Light yellow to yellow Solid
CAS DataBase Reference
25391-57-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38-43
Safety Statements 
26-36/37
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
A611350
Product name
2-Amino-5-iodo-3-nitropyridine
Packaging
5g
Price
$365
Updated
2021/12/16
Usbiological
Product number
415283
Product name
2-Amino-5-iodo-3-nitropyridine
Packaging
1g
Price
$403
Updated
2021/12/16
TRC
Product number
A611350
Product name
2-Amino-5-iodo-3-nitropyridine
Packaging
25g
Price
$1450
Updated
2021/12/16
AK Scientific
Product number
2060AB
Product name
5-Iodo-3-nitropyridin-2-amine
Packaging
25g
Price
$344
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA46246
Product name
2-Amino-5-iodo-3-nitropyridine
Packaging
50g
Price
$820
Updated
2021/12/16
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2-AMINO-5-IODO-3-NITROPYRIDINE Chemical Properties,Usage,Production

Uses

2-Amino-5-iodo-3-nitropyridine is used in the synthetic preparation of disubstituted pyridinyl azabicyclo heptanes as epibatidine analogs. These analogs are evaluated for its affinity for nicotinic acetylcholine receptors via in vitro and antinociceptive properties via in vivo in rats.

Synthesis

4214-75-9

25391-57-5

To a 250 mL three-necked flask were added 2-amino-3-nitropyridine (10.0 g, 72.0 mmol), acetic acid (44 mL) and water (10 mL). The mixture was heated to 90°C and then periodic acid (3.28 g, 14.4 mmol) and concentrated sulfuric acid (1.3 mL) at a mass percent concentration of 98% were added sequentially. After stirring for 10 min, iodine (9.1 g, 36.0 mmol) was added and stirring was continued for 60 min at this temperature. Upon completion of the reaction, the reaction solution was cooled to room temperature and subsequently poured into saturated aqueous sodium thiosulfate solution (100 mL). The solid product was separated by filtration and washed sequentially with saturated brine (50 mL x 2) and petroleum ether (50 mL x 2). The crude product was recrystallized using a mixed solvent of petroleum ether and ethyl acetate (5:1, v/v) to afford a high purity yellow solid 2-amino-5-iodo-3-nitropyridine (17.57 g, 69.1 mmol, 96% yield).

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 21, p. 4755 - 4761
[2] Patent: CN107325045, 2017, A. Location in patent: Paragraph 0006; 0009
[3] Patent: WO2013/53983, 2013, A1. Location in patent: Page/Page column 37
[4] Patent: US2015/11548, 2015, A1. Location in patent: Paragraph 0152

2-AMINO-5-IODO-3-NITROPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-AMINO-5-IODO-3-NITROPYRIDINE Suppliers

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View Lastest Price from 2-AMINO-5-IODO-3-NITROPYRIDINE manufacturers

Dideu Industries Group Limited
Product
2-AMINO-5-IODO-3-NITROPYRIDINE 25391-57-5
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-07
Career Henan Chemical Co
Product
2-AMINO-5-IODO-3-NITROPYRIDINE 25391-57-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kgs
Release date
2020-01-29

25391-57-5, 2-AMINO-5-IODO-3-NITROPYRIDINERelated Search:

2-AMINO-3-IODO-5-NITROPYRIDINE 5-IODO-PYRIDIN-3-YLAMINE 2-amino-5-iodo-3-pyridinylamine 2-AMINO-5-IODO-3-NITROPYRIDINE

  • 5-IODO-3-NITRO-PYRIDIN-2-YLAMINE
  • 2-AMINO-5-IODO-3-NITROPYRIDINE
  • 2-PYRIDINAMINE,5-IODO-3-NITRO
  • 2-Amino-3-nitro-5-iodopyridine
  • Zinc04202918
  • 5-iodo-3-nitropyridin-2-aMine
  • 5-iodo-3-nitro-2-pyridinamine
  • 2-Amino-5-iodo-3-nitropyridine 95+%
  • 2-AMINO-5-IODO-3-NITROPYRIDINE ISO 9001：2015 REACH
  • 25391-57-5
  • C5H4IN3O2
  • Halogenated Heterocycles
  • Pyridines
  • Heterocyclic Building Blocks
  • Building Blocks
  • Pyridines derivates
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines