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RESORUFIN ETHYL ETHER

Product Name
RESORUFIN ETHYL ETHER
CAS No.
5725-91-7
Chemical Name
RESORUFIN ETHYL ETHER
Synonyms
7-ER;ETHOXYRESORUFIN;7-ETHOXYRESORUFIN;O7-ETHYLRESORUFIN;7-Ethoxy Rresorufin;7-Ethoxyphenoxazone;RESORUFIN ETHYL ETHER;RESORUFIN ETHYL ESTER;7-ethoxyphenoxazin-3-one;Thiabendazole Impurity 19
CBNumber
CB3203954
Molecular Formula
C14H11NO3
Formula Weight
241.24
MOL File
5725-91-7.mol
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RESORUFIN ETHYL ETHER Property

Melting point:
223-225 °C (lit.)
Boiling point:
389.3±42.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: soluble
form 
Brown solid.
pka
1.43±0.20(Predicted)
color 
Dark Orange to Red
BRN 
225973
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Safety

WGK Germany 
3
8-10
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
46121
Product name
Resorufin ethyl ether
Purity
suitable for fluorescence, ≥95% (UV)
Packaging
5mg
Price
$429
Updated
2024/03/01
Sigma-Aldrich
Product number
46121
Product name
Resorufin ethyl ether
Purity
suitable for fluorescence, ≥95% (UV)
Packaging
25mg
Price
$1670
Updated
2024/03/01
Alfa Aesar
Product number
J62987
Product name
7-Ethoxyresorufin
Packaging
5mg
Price
$304.65
Updated
2024/03/01
Cayman Chemical
Product number
16122
Product name
7-Ethoxyresorufin
Purity
≥95%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
16122
Product name
7-Ethoxyresorufin
Purity
≥95%
Packaging
10mg
Price
$172
Updated
2024/03/01
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RESORUFIN ETHYL ETHER Chemical Properties,Usage,Production

Chemical Properties

Red Solid

Uses

A fluorimetric substrate for cytochrome P450 IAI. Inhibits vasorelaxant responses to acetylcholine

Uses

Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450.

Uses

Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).

Definition

ChEBI: 7-ethoxyresorufin is a phenoxazine.

General Description

Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.

Biological Activity

cytochrome p450, family 1, subfamily a, polypeptide 1 is a protein that is encoded by human cyp1a1 gene. the protein is a member of the cytochrome p450 superfamily of enzymes. cyp1a1 is involved in phase i xenobiotic and drug metabolism. cyp1a1 is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons. 7-ethoxyresorufin is a specific subtrate of cyp1a.

in vitro

7-ethoxyresorufin (2-10 microm), a substrate for cytochrome p450, which binds to the heme moiety of the enzyme, reduced responses to acetylcholine concentration-dependently but not the other agonists indicating an effect on nitric oxide synthesis although neither affected the conversion of l-arginine to l-citrulline [1].

in vivo

activities of cyp1a (7-ethoxyresorufin) in the liver was determined for comparative purposes. in mice, lps depressed cyp2a5 at low doses but not at doses that increased pro-inflammatory cytokines and no serum levels, and depressed cyp1a activity. blockade of proinflammatory cytokines extended down-regulation of cyp2a5 while not affecting lps-induced depression of cyp1a [2].

storage

Store at -20°C

References

[1] oyekan ao, mcgiff jc, rosencrantz-weiss p, quilley j. relaxant responses of rabbit aorta: influence of cytochrome p450 inhibitors. j pharmacol exp ther. 1994 jan;268(1):262-9.
[2] de-oliveira ac, poça ks, totino pr, paumgartten fj. modulation of cytochrome p450 2a5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship. plos one. 2015 jan 30;10(1):e0117842.
[3] pelkonen o, pasanen m, kuha h, gachalyi b, kairaluoma m, sotaniemi ea, park ss, friedman fk, gelboin hv. the effect of cigarette smoking on 7-ethoxyresorufin o-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. br j clin pharmacol. 1986 aug;22(2):125-34.

RESORUFIN ETHYL ETHER Preparation Products And Raw materials

Raw materials

Preparation Products

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RESORUFIN ETHYL ETHER Suppliers

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5725-91-7, RESORUFIN ETHYL ETHERRelated Search:


  • RESORUFIN ETHYL ESTER
  • RESORUFIN ETHYL ETHER
  • O7-ETHYLRESORUFIN
  • 7-ER
  • O(7)-ETHYLRESORUFIN, FOR FLUOR-
  • O(7)-ETHYLRESORUFIN FOR FLUORESCENCE
  • 7-Ethoxy-3H-phenoxazin-3-one, Resorufin Ethyl Ester
  • 3H-Phenoxazin-3-one, 7-ethoxy-
  • 7-ETHOXY-3H-PHENOXAZIN-3-ONE
  • 7-ETHOXYRESORUFIN
  • ETHOXYRESORUFIN
  • ETHOXYRESORUFIN [RESORUFIN ETHYL ETHER]
  • 7-ethoxyphenoxazin-3-one
  • Resorufin ethyl ether,7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin
  • 7-Ethoxy Rresorufin
  • Resorufin ethyl ether *CAS 5725-91-7*
  • 7-Ethoxy-3H-phenoxazin-3-one, Ethoxyresorufin, O7-Ethylresorufin
  • 7-Ethoxyphenoxazone
  • Nitric oxide synthases,7-Ethoxyresorufin,Cytochrome P450,CYP1A1,7 Ethoxyresorufin,inhibit,7Ethoxyresorufin,Inhibitor,substrate,CYPs,Fluorometric,NO Synthase,NOS
  • Thiabendazole Impurity 19
  • 5725-91-7
  • Fluorescent Probes, Labels, Particles and Stains
  • Fluorescent Enzyme Substrates
  • Alphabetical
  • Detection
  • BioChemical
  • Biochemicals and Reagents
  • Heterocycles
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals