5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

Product Name: 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
CAS No.: 1434-54-4
Chemical Name: 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
Synonyms: pcn;sc4674;U-14975;16-alpha-cyanopregnenolone;pregnenolone-16α-carbonitrile;Pregnenolone 16α-carbonitrile;5-PREGNEN-16α-CYANO-3β-OL-20-ONE;PREGNENOLONE-16ALPHA-CARBONITRILE;16α-Cyano-3β-hydroxypregn-5-en-20-one;5-pregnen-3B-ol-20-one-16A-carbonitrile
CBNumber: CB4150567
Molecular Formula: C22H31NO2
Formula Weight: 341.49
MOL File: 1434-54-4.mol

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Property

Melting point:: 225-228 °C(Solv: methanol (67-56-1); benzene (71-43-2))
Boiling point:: 508.5±50.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
Flash point:: 93 °C
storage temp.: 2-8°C
solubility: Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form: White to off-white solid.
pka: 14.95±0.70(Predicted)
color: White to off-white
biological source: synthetic (organic)
EPA Substance Registry System: Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3.beta.,16.alpha.)- (1434-54-4)

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Safety

WGK Germany: 3
RTECS: TU4536500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0543
Product name: 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity: ≥97%
Packaging: 50mg
Price: $81.51
Updated: 2025/07/31

Sigma-Aldrich

Product number: P0543
Product name: 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity: ≥97%
Packaging: 100mg
Price: $154
Updated: 2025/07/31

Cayman Chemical

Product number: 16343
Product name: Pregnenolone Carbonitrile
Purity: ≥98%
Packaging: 25mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 16343
Product name: Pregnenolone Carbonitrile
Purity: ≥98%
Packaging: 50mg
Price: $64
Updated: 2024/03/01

Sigma-Aldrich

Product number: P0543
Product name: 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity: ≥97%
Packaging: 250mg
Price: $298
Updated: 2025/07/31

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Chemical Properties,Usage,Production

Uses

Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).

Definition

ChEBI: Pregnenolone 16alpha-carbonitrile is an aliphatic nitrile. It is functionally related to a pregnenolone.

Biochem/physiol Actions

Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.

in vivo

Pregnenolone 16α-carbonitrile (40 mg/kg/day; i.p.; for two days) induces the expression of Cyp3a11 and Cyp2b10 at the mRNA, protein, and enzymatic levels in WT mice^[1].
? Pregnenolone 16α-carbonitrile (100 mg/kg; ip; single dose) induces the expression of CYP3A mRNA in adult female Sprague-Dawley rats weighing 150-200 g^[2].
? Pregnenolone 16α-carbonitrile (35 mg/kg; gavage; once daily for three days) increase in Pgp expression in male Sprague-Dawley rats, aged approximately 100 days and weighing 250-400 g^[3].

Animal Model:	WT and Pxr^-/- mice^[1]
Dosage:	40 mg/kg
Administration:	IP; per day for two days
Result:	Induced the expression of Cyp3a11 and Cyp2b10 at the mRNA, protein, and enzymatic levels in WT mice. Had little effect on the expression of Cyp3a11 in Pxr^-/- mice

IC 50

CYP2; CYP3

5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Suppliers

China 41 Germany 1 India 1 Switzerland 1 United Kingdom 2 United States 9 Global 55

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1434-54-4, 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILERelated Search:

CYCLOPENTANECARBONITRILE 2-METHYLDECANONITRILE N-DODECYL CYANIDE Dodecanenitrile N-OCTYL CYANIDE 3-METHYLDODECANONITRILE ORANILE Decanonitrile ISOCAPRONITRILE 3-Methylbutanenitrile OCTANENITRILE Pregnenolone 6-METHYLHEPTANENITRILE 7-OCTENENITRILE 16-ALPHA-METHYLPREGNENOLONE 3-METHYLVALERONITRILE 2-PROPYLVALERONITRILE 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

5-pregnen-3B-ol-20-one-16A-carbonitrile

(3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile

(3S,8S,9S,10R,13S,14S,16R,17S)-17-ethanoyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile

pregnenolone-16α-carbonitrile

16α-Cyano-3β-hydroxypregn-5-en-20-one

U-14975

16-alpha)-3-hydroxy-20-oxopregn-5-ene-16-carbonitrile(3-bet

16-alpha-cyanopregnenolone

3beta-hydroxy-20-oxo-pregn-5-ene-16-alpha-carbonitril

3-hydroxy-20-oxo-,(3-beta,16-alpha)-pregn-5-ene-16-carbonitril

pcn

sc4674

PREGNENOLONE-16ALPHA-CARBONITRILE

Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3β,16α)-

CYPs,Cytochrome P450,P4503A,orally,Pregnenolone Carbonitrile,Pregnenolone 16α-carbonitrile,Inhibitor,PXR,cytochrome,inhibit

5-PREGNEN-16α-CYANO-3β-OL-20-ONE

Pregnenolone 16α-carbonitrile

Pregnenolone-16alpha-carbonitrile, Cytochrome P-450 inducer

Pregnenolone Carbonitrile, 10 mM in DMSO

5-Pregnen-3β-ol-20-one-16α-carbonitrile, CAS 1434-54-4

1434-54-4

C22H31NO2

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Cytokines, Growth Factors and Hormones

Corticosterone

Hormones

Steroid Hormones