ChemicalBook > CAS DataBase List > 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

Product Name
5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
CAS No.
1434-54-4
Chemical Name
5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
Synonyms
pcn;sc4674;U-14975;16-alpha-cyanopregnenolone;pregnenolone-16α-carbonitrile;Pregnenolone 16α-carbonitrile;5-PREGNEN-16α-CYANO-3β-OL-20-ONE;PREGNENOLONE-16ALPHA-CARBONITRILE;16α-Cyano-3β-hydroxypregn-5-en-20-one;5-pregnen-3B-ol-20-one-16A-carbonitrile
CBNumber
CB4150567
Molecular Formula
C22H31NO2
Formula Weight
341.49
MOL File
1434-54-4.mol
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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Property

Melting point:
225-228 °C(Solv: methanol (67-56-1); benzene (71-43-2))
Boiling point:
508.5±50.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
Flash point:
93 °C
storage temp. 
2-8°C
solubility 
Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form 
White to off-white solid.
pka
14.95±0.70(Predicted)
EPA Substance Registry System
Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3.beta.,16.alpha.)- (1434-54-4)
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Safety

WGK Germany 
3
RTECS 
TU4536500
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0543
Product name
5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity
≥97%
Packaging
50mg
Price
$83.5
Updated
2024/03/01
Sigma-Aldrich
Product number
P0543
Product name
5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity
≥97%
Packaging
100mg
Price
$150
Updated
2024/03/01
Cayman Chemical
Product number
16343
Product name
Pregnenolone Carbonitrile
Purity
≥98%
Packaging
25mg
Price
$40
Updated
2024/03/01
Cayman Chemical
Product number
16343
Product name
Pregnenolone Carbonitrile
Purity
≥98%
Packaging
50mg
Price
$64
Updated
2024/03/01
Sigma-Aldrich
Product number
P0543
Product name
5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity
≥97%
Packaging
250mg
Price
$290
Updated
2024/03/01
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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Chemical Properties,Usage,Production

Uses

Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).

Definition

ChEBI: Pregnenolone 16alpha-carbonitrile is an aliphatic nitrile. It is functionally related to a pregnenolone.

Biochem/physiol Actions

Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.

5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Suppliers

Shanghai Macklin Biochemical Co.,Ltd.
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1434-54-4, 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILERelated Search:


  • 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
  • 5-pregnen-3B-ol-20-one-16A-carbonitrile
  • (3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
  • (3S,8S,9S,10R,13S,14S,16R,17S)-17-ethanoyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile
  • pregnenolone-16α-carbonitrile
  • 16α-Cyano-3β-hydroxypregn-5-en-20-one
  • U-14975
  • 16-alpha)-3-hydroxy-20-oxopregn-5-ene-16-carbonitrile(3-bet
  • 16-alpha-cyanopregnenolone
  • 3beta-hydroxy-20-oxo-pregn-5-ene-16-alpha-carbonitril
  • 3-hydroxy-20-oxo-,(3-beta,16-alpha)-pregn-5-ene-16-carbonitril
  • pcn
  • sc4674
  • PREGNENOLONE-16ALPHA-CARBONITRILE
  • Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3β,16α)-
  • CYPs,Cytochrome P450,P4503A,orally,Pregnenolone Carbonitrile,Pregnenolone 16α-carbonitrile,Inhibitor,PXR,cytochrome,inhibit
  • 5-PREGNEN-16α-CYANO-3β-OL-20-ONE
  • Pregnenolone 16α-carbonitrile
  • 1434-54-4
  • C22H31NO2
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Cytokines, Growth Factors and Hormones
  • Corticosterone
  • Hormones
  • Steroid Hormones