5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

Product Name: 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
CAS No.: 1434-54-4
Chemical Name: 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE
Synonyms: pcn;sc4674;U-14975;16-alpha-cyanopregnenolone;pregnenolone-16α-carbonitrile;Pregnenolone 16α-carbonitrile;5-PREGNEN-16α-CYANO-3β-OL-20-ONE;PREGNENOLONE-16ALPHA-CARBONITRILE;16α-Cyano-3β-hydroxypregn-5-en-20-one;5-pregnen-3B-ol-20-one-16A-carbonitrile
CBNumber: CB4150567
Molecular Formula: C22H31NO2
Formula Weight: 341.49
MOL File: 1434-54-4.mol

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Property

Melting point:: 225-228 °C(Solv: methanol (67-56-1); benzene (71-43-2))
Boiling point:: 508.5±50.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
Flash point:: 93 °C
storage temp.: 2-8°C
solubility: Acetonitrile: 1 mg/ml; Ethanol: 1 mg/ml; Methanol: 1 mg/ml
form: White to off-white solid.
pka: 14.95±0.70(Predicted)
color: White to off-white
EPA Substance Registry System: Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3.beta.,16.alpha.)- (1434-54-4)

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Safety

WGK Germany: 3
RTECS: TU4536500

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0543
Product name: 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity: ≥97%
Packaging: 50mg
Price: $83.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: P0543
Product name: 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity: ≥97%
Packaging: 100mg
Price: $150
Updated: 2024/03/01

Cayman Chemical

Product number: 16343
Product name: Pregnenolone Carbonitrile
Purity: ≥98%
Packaging: 25mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 16343
Product name: Pregnenolone Carbonitrile
Purity: ≥98%
Packaging: 50mg
Price: $64
Updated: 2024/03/01

Sigma-Aldrich

Product number: P0543
Product name: 5-Pregnen-3β-ol-20-one-16α-carbonitrile
Purity: ≥97%
Packaging: 250mg
Price: $290
Updated: 2024/03/01

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Chemical Properties,Usage,Production

Uses

Pregnenolone Carbonitrile is a glucocorticoid receptor antagonist that induces the expression of the CYP3A family of steroid hydroxylases and modulates sterol and bile acid biosynthesis in vivo. Pregnenolone Carbonitrile is an an activator of rat pregnane X receptor (PXR).

Definition

ChEBI: Pregnenolone 16alpha-carbonitrile is an aliphatic nitrile. It is functionally related to a pregnenolone.

Biochem/physiol Actions

Pregnenolone-16a-carbonitrile (PCN) is a glucocorticoid receptor antagonist and a PXR (pregnane X receptor) activator.

5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE Suppliers

China 22 Germany 1 India 1 Switzerland 1 United Kingdom 2 United States 8 Global 35

Shanghai Macklin Biochemical Co.,Ltd.

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1434-54-4, 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILERelated Search:

CYCLOPENTANECARBONITRILE 2-METHYLDECANONITRILE N-DODECYL CYANIDE Dodecanenitrile N-OCTYL CYANIDE 3-METHYLDODECANONITRILE ORANILE Decanonitrile ISOCAPRONITRILE 3-Methylbutanenitrile OCTANENITRILE Pregnenolone 6-METHYLHEPTANENITRILE 7-OCTENENITRILE 16-ALPHA-METHYLPREGNENOLONE 3-METHYLVALERONITRILE 2-PROPYLVALERONITRILE 5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

5-PREGNEN-3BETA-OL-20-ONE-16ALPHA-CARBONITRILE

5-pregnen-3B-ol-20-one-16A-carbonitrile

(3S,8S,9S,10R,13S,14S,16R,17S)-17-acetyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile

(3S,8S,9S,10R,13S,14S,16R,17S)-17-ethanoyl-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-16-carbonitrile

pregnenolone-16α-carbonitrile

16α-Cyano-3β-hydroxypregn-5-en-20-one

U-14975

16-alpha)-3-hydroxy-20-oxopregn-5-ene-16-carbonitrile(3-bet

16-alpha-cyanopregnenolone

3beta-hydroxy-20-oxo-pregn-5-ene-16-alpha-carbonitril

3-hydroxy-20-oxo-,(3-beta,16-alpha)-pregn-5-ene-16-carbonitril

pcn

sc4674

PREGNENOLONE-16ALPHA-CARBONITRILE

Pregn-5-ene-16-carbonitrile, 3-hydroxy-20-oxo-, (3β,16α)-

CYPs,Cytochrome P450,P4503A,orally,Pregnenolone Carbonitrile,Pregnenolone 16α-carbonitrile,Inhibitor,PXR,cytochrome,inhibit

5-PREGNEN-16α-CYANO-3β-OL-20-ONE

Pregnenolone 16α-carbonitrile

1434-54-4

C22H31NO2

BioChemical

Cell Signaling and Neuroscience

Cell Biology

Cytokines, Growth Factors and Hormones

Corticosterone

Hormones

Steroid Hormones