RESORUFIN ETHYL ETHER
- Product Name
- RESORUFIN ETHYL ETHER
- CAS No.
- 5725-91-7
- Chemical Name
- RESORUFIN ETHYL ETHER
- Synonyms
- 7-ER;ETHOXYRESORUFIN;7-ETHOXYRESORUFIN;O7-ETHYLRESORUFIN;7-Ethoxy Rresorufin;7-Ethoxyphenoxazone;RESORUFIN ETHYL ETHER;RESORUFIN ETHYL ESTER;7-ethoxyphenoxazin-3-one;Thiabendazole Impurity 19
- CBNumber
- CB3203954
- Molecular Formula
- C14H11NO3
- Formula Weight
- 241.24
- MOL File
- 5725-91-7.mol
RESORUFIN ETHYL ETHER Property
- Melting point:
- 223-225 °C (lit.)
- Boiling point:
- 389.3±42.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMF: soluble
- form
- Brown solid.
- pka
- 1.43±0.20(Predicted)
- color
- Dark Orange to Red
- BRN
- 225973
Safety
- WGK Germany
- 3
- F
- 8-10
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
N-Bromosuccinimide Price
- Product number
- 46121
- Product name
- Resorufin ethyl ether
- Purity
- suitable for fluorescence, ≥95% (UV)
- Packaging
- 5mg
- Price
- $429
- Updated
- 2024/03/01
- Product number
- 46121
- Product name
- Resorufin ethyl ether
- Purity
- suitable for fluorescence, ≥95% (UV)
- Packaging
- 25mg
- Price
- $1670
- Updated
- 2024/03/01
- Product number
- J62987
- Product name
- 7-Ethoxyresorufin
- Packaging
- 5mg
- Price
- $304.65
- Updated
- 2024/03/01
- Product number
- 16122
- Product name
- 7-Ethoxyresorufin
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 16122
- Product name
- 7-Ethoxyresorufin
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $172
- Updated
- 2024/03/01
RESORUFIN ETHYL ETHER Chemical Properties,Usage,Production
Chemical Properties
Red Solid
Uses
A fluorimetric substrate for cytochrome P450 IAI. Inhibits vasorelaxant responses to acetylcholine
Uses
Dealkylase substrate for the microfluorimetric analysis of microsomal cytochrome P-450.
Uses
Resorufin ethyl ether is suitable for the study of dealkylating activity of cytochrome P450 isozymes 1A1 and 1A2, where arylalkyl and alkyl isothiocyanates, and their glutathione, cysteine, and A′-acetylcysteine conjugates are used as inhibitors. It is suitable to study the ethoxyresorufin-O-deethylase (EROD) activity of cytochrome P450 activity (CYP1A1).
Definition
ChEBI: 7-ethoxyresorufin is a phenoxazine.
General Description
Resorufin ethers are used as markers or substrates for different cytochrome P (CYP) isoforms. Resorufin ethyl ether is the preferred resorufin ether to be metabolized by microsomes of 3-methylcholanthrene treated animals.
Biological Activity
cytochrome p450, family 1, subfamily a, polypeptide 1 is a protein that is encoded by human cyp1a1 gene. the protein is a member of the cytochrome p450 superfamily of enzymes. cyp1a1 is involved in phase i xenobiotic and drug metabolism. cyp1a1 is inhibited by fluoroquinolones and macrolides and induced by aromatic hydrocarbons. 7-ethoxyresorufin is a specific subtrate of cyp1a.
in vitro
7-ethoxyresorufin (2-10 microm), a substrate for cytochrome p450, which binds to the heme moiety of the enzyme, reduced responses to acetylcholine concentration-dependently but not the other agonists indicating an effect on nitric oxide synthesis although neither affected the conversion of l-arginine to l-citrulline [1].
in vivo
activities of cyp1a (7-ethoxyresorufin) in the liver was determined for comparative purposes. in mice, lps depressed cyp2a5 at low doses but not at doses that increased pro-inflammatory cytokines and no serum levels, and depressed cyp1a activity. blockade of proinflammatory cytokines extended down-regulation of cyp2a5 while not affecting lps-induced depression of cyp1a [2].
storage
Store at -20°C
References
[1] oyekan ao, mcgiff jc, rosencrantz-weiss p, quilley j. relaxant responses of rabbit aorta: influence of cytochrome p450 inhibitors. j pharmacol exp ther. 1994 jan;268(1):262-9.
[2] de-oliveira ac, poça ks, totino pr, paumgartten fj. modulation of cytochrome p450 2a5 activity by lipopolysaccharide: low-dose effects and non-monotonic dose-response relationship. plos one. 2015 jan 30;10(1):e0117842.
[3] pelkonen o, pasanen m, kuha h, gachalyi b, kairaluoma m, sotaniemi ea, park ss, friedman fk, gelboin hv. the effect of cigarette smoking on 7-ethoxyresorufin o-deethylase and other monooxygenase activities in human liver: analyses with monoclonal antibodies. br j clin pharmacol. 1986 aug;22(2):125-34.
RESORUFIN ETHYL ETHER Preparation Products And Raw materials
Raw materials
Preparation Products
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