ChemicalBook > CAS DataBase List > 2'-Deoxyguanosine

2'-Deoxyguanosine

Product Name
2'-Deoxyguanosine
CAS No.
961-07-9
Chemical Name
2'-Deoxyguanosine
Synonyms
2;DG;deoxyguanosine;2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one;2'-dG;-O-DMT;NSC 22837;D8415_SIGMA;Guanine, 9-(;Oprea1_013861
CBNumber
CB3209022
Molecular Formula
C10H13N5O4
Formula Weight
267.24
MOL File
961-07-9.mol
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2'-Deoxyguanosine Property

Melting point:
300 °C
Boiling point:
410.43°C (rough estimate)
Density 
1.3382 (rough estimate)
refractive index 
-42 ° (C=0.2, 1mol/L NaOH)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
NH4OH 1 M: 50 mg/mL, clear to very faintly turbid, yellow to brown
form 
powder
pka
9?+-.0.20(Predicted)
color 
White to Off-white
PH
2.37；9.33
optical activity
Consistent with structure
Water Solubility 
Slightly soluble in water.
λmax
255 (pH 1)
BRN 
39814
InChIKey
OROIAVZITJBGSM-OJFKHTATSA-N
CAS DataBase Reference
961-07-9(CAS DataBase Reference)
NIST Chemistry Reference
Deoxyguanosine(961-07-9)
EPA Substance Registry System
Guanosine, 2'-deoxy- (961-07-9)
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Safety

Risk Statements 
20/21/22
Safety Statements 
24/25
WGK Germany 
3
RTECS 
MF8760000
F 
10-23
TSCA 
Yes
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
D0052
Product name
2'-Deoxyguanosine Hydrate
Purity
>98.0%(T)
Packaging
1g
Price
$51
Updated
2025/07/31
TCI Chemical
Product number
D0052
Product name
2'-Deoxyguanosine Hydrate
Purity
>98.0%(T)
Packaging
5g
Price
$150
Updated
2025/07/31
Cayman Chemical
Product number
9002864
Product name
2''-Deoxyguanosine
Packaging
5g
Price
$88
Updated
2021/12/16
Cayman Chemical
Product number
9002864
Product name
2''-Deoxyguanosine
Packaging
1g
Price
$35
Updated
2021/12/16
TCI Chemical
Product number
D0052
Product name
2'-Deoxyguanosine Hydrate
Purity
>98.0%(T)
Packaging
25g
Price
$448
Updated
2025/07/31
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2'-Deoxyguanosine Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents.

Uses

2'-Deoxyguanosine (Deoxyguanosine; dG) is composed of the purine nucleoside guanine linked by its N9 nitrogen to the C1 carbon of deoxyribose. It is a purine nucleoside that upon sequential phosphoylation (kinases) forms dGTP which is used by DNA polymerases and reverse transcriptases to synthesis DNA(s). Deoxyguanosine is the most electron rich of the four canonical bases and includes many nucleophilic sites which are susceptible to oxidative damage. This makes deoxyguanosine and its oxidized derivatives useful reagents to study mechanisms of oxidative damage to nucleosides and nucleotides.

Definition

ChEBI: 2'-deoxyguanosine is a purine 2'-deoxyribonucleoside having guanine as the nucleobase. It has a role as a Saccharomyces cerevisiae metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a purines 2'-deoxy-D-ribonucleoside and a purine 2'-deoxyribonucleoside. It is functionally related to a guanosine.

benefits

8-Hydroxy-2'-deoxyguanosine (8-OHdG) is the most commonly used marker of DNA oxidation for the diagnosis of oxidative DNA damage and bipolar disorder (BD), as well as for the prevention of plaque formation and for the inhibition of vascular smooth muscle cell activation through Rac1 inactivation.

Biological Functions

2‘-Deoxyguanosine (2’dGuo) is a purine nucleoside metabolite that has been shown to inhibit proliferation-dependent antigen-specific suppressor T cell (Ts) function in mouse and human systems. 2'dGuo also inhibits mitogen-induced T cell proliferation. Low concentrations (40 gM) of 2'dGuo enhanced phytohemagglutinin- and amantadine A-induced T-cell transformation, possibly due to the inhibition of T-cell function leading to the promotion of T-cell growth factor production. T-cell responses were inhibited only when the concentration of 2'dGuo was toxic to lymphocytes.[1]

IC 50

Human Endogenous Metabolite

Purification Methods

2'-Deoxyguanosine recrystallises from H2O as the monohydrate. [Brown &C5440 Lythgoe J Chem Soc 1990 1950, L

References

[1] A C HANGLOW; P M L. The effect of 2’deoxyguanosine on human lymphocyte responses. I. 2’deoxyguanosine enhances T lymphocyte responses.[J]. Clinical and experimental immunology, 1985, 59 3: 653-658.

2'-Deoxyguanosine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2'-Deoxyguanosine manufacturers

Xinxiang Aurora Biotechnology Co.,Ltd.
Product
2'-Deoxyguanosine 961-07-9
Price
US $10.00-99.00/Kg
Min. Order
1Kg
Purity
98%
Supply Ability
1000kg
Release date
2025-10-10
HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
2'-Deoxyguanosine 961-07-9
Price
US $0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
20tons
Release date
2025-08-27
WeiTai BioPharmaceutical Co.,Ltd(Hangzhou?)
Product
2'-Deoxyguanosine monohydrate(2'-dG) 961-07-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%HPLC
Supply Ability
1000T
Release date
2025-08-19

961-07-9, 2'-DeoxyguanosineRelated Search:

Deoxycholic acid MELIBIOSE Guanosine Guanine Acyclovir Chloral hydrate Guanosine 5'-monophosphate disodium salt 5'-Guanylic acid DNA, SINGLE STRANDED, IMM. ON CELLULOSE, FROM CALF THYMUS* Guanylic acid sodium salt 2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA),2'-DEOXYGUANOSINE5'-MONOPHOSPHATE,DISODIUM SALT(DGMP·2NA) 2’-deoxyguanosine5’-phosphat 2’-deoxyguanosine5’-(tetrahydrogentriphosphate N2-ISOBUTYRYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE,N2-ISOBUTYRYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYGUANOSINE [5',5''-2H2]2'-DEOXYGUANOSINE MONOHYDRATE 3'-deoxyguanosine monohydrate hydrate hydrazine hydrate

  • DEOXYGUANOSINE-2'
  • DG
  • GUANINE DESOXYRIBOSIDE
  • 2'-DEOXY-D-GUANOSINE
  • A-2'-DEOXYGUANOSINE
  • 9-(2'-DEOXY-BETA-D-RIBOFURANOSYL)GUANINE
  • O6-Methyl-2&rsquo
  • 2(acute)-Deoxyguanosine
  • 2-amino-9-(4-hydroxy-5-methylol-tetrahydrofuran-2-yl)-3H-purin-6-one
  • 2-amino-9-[4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]-3H-purin-6-one
  • 2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1,9-dihydro-6H-purin-6-one
  • 2-amino-9-[4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-3H-purin-6-one
  • 9H-Purin-6-ol, 2-amino-9-(2-deoxy-9-beta-D-ribofuranosyl)-
  • deoxyephedrinearenol2’-deoxyguanosine
  • deoxyguanosine
  • Desoxyguanosine
  • Guanine deoxy nucleoside
  • Guanine deoxyriboside
  • Guanine, 9-(2-deoxy-beta-D-erythro-pentofuranosyl)-
  • 2-DEOXYGUANOSINE extrapure
  • 9-(2-Deoxy-β-D-ribofuranosyl)guanine, Guanine-2μ-deoxyriboside
  • Norway saltpeter-15N2
  • 2'-Deoxyguanosine ,98%
  • 2'-Deoxyguanosine mo
  • 2'-DEOXYGUANOSINE:H2O
  • 2’-deoxy-guanosin
  • Deoxyguanosine Monohydrat
  • 2-aMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-purin-6(9H)-one hydrate
  • 2'-Deoxyguanosine Monohydrate SynonyMs 9-(2-Deoxy-beta-D-ribofuranosyl)guanine hydrate
  • 2-AMino-9-((2R,4S,5R)-4-hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-one
  • 2'-Deoxyguanosine Hydrate, 98.0%(T)
  • -deoxy-N2-DMF-5&rsquo
  • -O-DMT
  • 8-Allyloxy-N2-(dimethylaminomethylidene)-2&rsquo
  • -deoxy Guanosine-13C2,D, Major
  • O6-(2-Hydroxy-1-methylethyl)-2&rsquo
  • 7-Ethyl-2&rsquo
  • N2-Methyl-2&rsquo
  • O6-(2-Hydroxypropyl)-2&rsquo
  • 8-Aza-7-deaza-2&rsquo
  • 2'-Desoxyguanosin
  • 7-Methyl-7-deaza-2&rsquo
  • N1-Methyl-2&rsquo
  • 8-Oxo-N2-isobutyryl-2&rsquo
  • 8-(4-Amino-phenyl)-2&rsquo
  • 9-(2-Deoxy-β-D-ribofuranosyl)guanine
  • Guanine-2'-deoxyriboside
  • 2'-DEOXYGUANOSINE CELL CULTURE TESTED
  • DeoxyguanosineMonohydrate,Isolated
  • 2'-Deoxyguanosine hydrate, 99+%
  • 9-(2-deoxy-á-d-ribofuranosyl)guanine hydrate
  • guanine-2'-deoxyriboside hydrate
  • 2-amino-9-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purin-6-one
  • guaninedeoxyriboside
  • Guanosine, 2'-deoxy-
  • NSC 22837
  • 9-(2-Deoxy-beta-D-ribofuranosyl)guanine hydrate
  • Guanine-2'-deoxyriboside monohydrate