4,5-DIFLUORO-2-NITROANILINE
- Product Name
- 4,5-DIFLUORO-2-NITROANILINE
- CAS No.
- 78056-39-0
- Chemical Name
- 4,5-DIFLUORO-2-NITROANILINE
- Synonyms
- 4,5-DifL;2-Amino-4,5-diflu;BUTTPARK 19\04-57;4,5-DIFLUORO-2-NITRO;3,4-DIFLUORO-2-NITROANILINE;4,5-DIFLUORO-2-NITROANILINE;3,4-DIFLUORO-6-NITRO ANILINE;4,5-Difluoro-2-nitroaniline>4,5-DIFLUORO-2-NITROANILINE 99%;4,5-Difluoro-2-nitroaniline,98%
- CBNumber
- CB3212349
- Molecular Formula
- C6H4F2N2O2
- Formula Weight
- 174.1
- MOL File
- 78056-39-0.mol
4,5-DIFLUORO-2-NITROANILINE Property
- Melting point:
- 107-108 °C (lit.)
- Boiling point:
- 308.1±37.0 °C(Predicted)
- Density
- 1.554±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- soluble in Methanol
- pka
- -1.25±0.25(Predicted)
- form
- Crystalline Powder
- color
- Golden to orange
- BRN
- 2723242
- InChI
- InChI=1S/C6H4F2N2O2/c7-3-1-5(9)6(10(11)12)2-4(3)8/h1-2H,9H2
- InChIKey
- WDMCABATCGQAKK-UHFFFAOYSA-N
- SMILES
- C1(N)=CC(F)=C(F)C=C1[N+]([O-])=O
- CAS DataBase Reference
- 78056-39-0(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 292478
- Product name
- 4,5-Difluoro-2-nitroaniline
- Purity
- 98%
- Packaging
- 1g
- Price
- $53.7
- Updated
- 2023/01/07
- Product number
- D3644
- Product name
- 4,5-Difluoro-2-nitroaniline
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- D3644
- Product name
- 4,5-Difluoro-2-nitroaniline
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $255
- Updated
- 2025/07/31
- Product number
- D451175
- Product name
- 4,5-Difluoro-2-nitroaniline
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D451175
- Product name
- 4,5-Difluoro-2-nitroaniline
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
4,5-DIFLUORO-2-NITROANILINE Chemical Properties,Usage,Production
Chemical Properties
Golden to orange crystalline powder
Uses
4,5-Difluoro-2-nitroaniline has been used in the preparation of:
- 2-chloro-5,6-difluorobenzimidazole
- 1-(4,5-difluoro-2-nitrophenyl)pyrene via diazotization reaction with isoamyl nitrite in the presence of pyrene
- 5-ethoxy-6-fluorobenzofuroxan
Synthesis
2105-61-5
78056-39-0
General procedure for the synthesis of 2-nitro-4,5-difluoroaniline from 2,4,5-trifluoronitrobenzene: Ammonia (15 mL) was added to a solution of 1,2,4-trifluoro-5-nitrobenzene (1) (5.00 g, 28.0 mmol, 1.00 eq.) in methanol (5 mL) and the mixture was transferred to a microwave reaction flask. The reaction mixture was placed in a microwave reactor and heated at 70 °C for 90 min. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 1:4) to afford the target compound 2 (0.600 g, 12.0% yield) as a yellow solid. Thin layer chromatography (TLC) analytical conditions: 30% ethyl acetate/hexane (Rf value: 0.35); 1H NMR (500 MHz, CDCl3) data: δ 8.00 (t, J = 9.0 Hz, 1H), 6.65-6.58 (m, 1H), 6.08 (br s, 2H).
References
[1] Patent: US2013/287686, 2013, A1. Location in patent: Paragraph 0144; 0145
[2] Journal of Medicinal Chemistry, 1965, vol. 8, p. 737 - 740
[3] Patent: US2018/185362, 2018, A1. Location in patent: Paragraph 0556; 0557; 0558; 0559
4,5-DIFLUORO-2-NITROANILINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4,5-DIFLUORO-2-NITROANILINE manufacturers
- Product
- 4,5-DIFLUORO-2-NITROANILINE 78056-39-0
- Price
- US $70.00-700.00/kg
- Min. Order
- 10kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-11-09
- Product
- 4,5-DIFLUORO-2-NITROANILINE 78056-39-0
- Price
- US $10.00/KG/Tin
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100
- Release date
- 2019-06-28