ChemicalBook > CAS DataBase List > 4,5-DIFLUORO-2-NITROANILINE

4,5-DIFLUORO-2-NITROANILINE

Product Name: 4,5-DIFLUORO-2-NITROANILINE
CAS No.: 78056-39-0
Chemical Name: 4,5-DIFLUORO-2-NITROANILINE
Synonyms: 4,5-DifL;2-Amino-4,5-diflu;BUTTPARK 19\04-57;4,5-DIFLUORO-2-NITRO;3,4-DIFLUORO-2-NITROANILINE;4,5-DIFLUORO-2-NITROANILINE;3,4-DIFLUORO-6-NITRO ANILINE;4,5-Difluoro-2-nitroaniline>4,5-DIFLUORO-2-NITROANILINE 99%;4,5-Difluoro-2-nitroaniline,98%
CBNumber: CB3212349
Molecular Formula: C6H4F2N2O2
Formula Weight: 174.1
MOL File: 78056-39-0.mol

Less

4,5-DIFLUORO-2-NITROANILINE Property

Melting point:: 107-108 °C (lit.)
Boiling point:: 308.1±37.0 °C(Predicted)
Density: 1.554±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: soluble in Methanol
pka: -1.25±0.25(Predicted)
form: Crystalline Powder
color: Golden to orange
BRN: 2723242
InChI: InChI=1S/C6H4F2N2O2/c7-3-1-5(9)6(10(11)12)2-4(3)8/h1-2H,9H2
InChIKey: WDMCABATCGQAKK-UHFFFAOYSA-N
SMILES: C1(N)=CC(F)=C(F)C=C1[N+]([O-])=O
CAS DataBase Reference: 78056-39-0(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
RIDADR: 2811
WGK Germany: 3
F: 10
Hazard Note: Irritant
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29214200

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 292478
Product name: 4,5-Difluoro-2-nitroaniline
Purity: 98%
Packaging: 1g
Price: $53.7
Updated: 2023/01/07

TCI Chemical

Product number: D3644
Product name: 4,5-Difluoro-2-nitroaniline
Purity: >98.0%(GC)
Packaging: 5g
Price: $64
Updated: 2025/07/31

TCI Chemical

Product number: D3644
Product name: 4,5-Difluoro-2-nitroaniline
Purity: >98.0%(GC)
Packaging: 25g
Price: $255
Updated: 2025/07/31

TRC

Product number: D451175
Product name: 4,5-Difluoro-2-nitroaniline
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D451175
Product name: 4,5-Difluoro-2-nitroaniline
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Less

4,5-DIFLUORO-2-NITROANILINE Chemical Properties,Usage,Production

Chemical Properties

Golden to orange crystalline powder

Uses

4,5-Difluoro-2-nitroaniline has been used in the preparation of:

2-chloro-5,6-difluorobenzimidazole
1-(4,5-difluoro-2-nitrophenyl)pyrene via diazotization reaction with isoamyl nitrite in the presence of pyrene
5-ethoxy-6-fluorobenzofuroxan

Synthesis

2105-61-5

78056-39-0

General procedure for the synthesis of 2-nitro-4,5-difluoroaniline from 2,4,5-trifluoronitrobenzene: Ammonia (15 mL) was added to a solution of 1,2,4-trifluoro-5-nitrobenzene (1) (5.00 g, 28.0 mmol, 1.00 eq.) in methanol (5 mL) and the mixture was transferred to a microwave reaction flask. The reaction mixture was placed in a microwave reactor and heated at 70 °C for 90 min. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently evaporated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 1:4) to afford the target compound 2 (0.600 g, 12.0% yield) as a yellow solid. Thin layer chromatography (TLC) analytical conditions: 30% ethyl acetate/hexane (Rf value: 0.35); 1H NMR (500 MHz, CDCl3) data: δ 8.00 (t, J = 9.0 Hz, 1H), 6.65-6.58 (m, 1H), 6.08 (br s, 2H).

References

[1] Patent: US2013/287686, 2013, A1. Location in patent: Paragraph 0144; 0145
[2] Journal of Medicinal Chemistry, 1965, vol. 8, p. 737 - 740
[3] Patent: US2018/185362, 2018, A1. Location in patent: Paragraph 0556; 0557; 0558; 0559

4,5-DIFLUORO-2-NITROANILINE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4,5-DIFLUORO-2-NITROANILINE Suppliers

Americas 1 China 166 Europe 4 France 1 Germany 4 India 6 Italy 1 Japan 1 Switzerland 1 United Kingdom 12 United States 34 Global 231

Shanghai Harvest Chemical Industrial Co., Ltd.

Tel: 021-31038972,31038973 17321035817
Fax: +86-21-51385350
Email: sales@harvest-chem.com
Country: China
ProdList: 2816
Advantage: 64

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 4006356688 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

ShangHai DEMO Chemical Co.,Ltd

Tel: 400-021-7337 2355568890
Fax: 0086-21-50182339
Email: sales@demochem.com
Country: China
ProdList: 2572
Advantage: 57

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2805
Advantage: 65

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16077
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Beijing Eternalchem Co,. Ltd.

Tel: 010-59484199 18611897322
Email: sales@eternalchem.com
Country: China
ProdList: 4383
Advantage: 60

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

Shanghai Ennopharm Co., Ltd.

Tel: +86 (21) 6435-5022
Country: China
ProdList: 4267
Advantage: 65

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9815
Advantage: 79

Maya High Purity Chemicals

Tel: +86 (573) 82222445 (0)18006601000 452520369
Fax: +86 (573) 82222643
Email: sales@maya-r.com
Country: China
ProdList: 11707
Advantage: 57

ZhengZhou HuaWen Chemical Co.Ltd

Tel: 0370-2785118 17550508557
Fax: QQ：3470079902
Email: 675141927@qq.com
Country: China
ProdList: 3199
Advantage: 55

Wuhan Haizheng Industry & Trade Development Co. Ltd

Tel: 027-8866 0053/88660577/88660578
Fax: 027-8899 1911
Country: China
ProdList: 1073
Advantage: 55

Shanghai civi chemical technology co.,Ltd

Tel: 86-21-34053660
Fax: 86-21-34053661
Email: sale@labgogo.com
Country: China
ProdList: 9865
Advantage: 52

Thermo Fisher Scientific

Tel: 800-810-5118
Fax: +86-10-84193589
Email: cnchemical@thermofisher.com
Country: China
ProdList: 17770
Advantage: 75

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 17798518460
Fax: (1)02557626880
Email: cfzhang@aikonchem.com
Country: China
ProdList: 19913
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 18209
Advantage: 56

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

The future of Shanghai Industrial Co., Ltd.

Tel: 021-61552785
Fax: 021-55660885
Email: sales@shshiji.com
Country: China
ProdList: 9546
Advantage: 55

Wuhan Kaymke Chemical Co., Ltd.,

Tel: 027-027-87342388 18086026008
Fax: 027-87342388
Email: sales@kaymke.com
Country: China
ProdList: 3731
Advantage: 55

Shanghai Yolne Chemical Co., Ltd.

Tel: 021-62960152
Fax: 021-52212593
Email: 934678158@qq.com
Country: China
ProdList: 9899
Advantage: 55

Shanghai Raise Chemical Technology Co.,Ltd

Tel: +86-021-50935922
Fax: +86-021-33847795
Country: China
ProdList: 7865
Advantage: 55

Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: +86-28-85122536 85324413
Fax: +86-28-85326443
Email: market@astatech.cn
Country: China
ProdList: 8026
Advantage: 55

Shanghai Run-Biotech Co., Ltd.

Tel: 021-57171705 13817537615
Fax: QQ3095748324
Email: sales@run-biotech.com
Country: China
ProdList: 2332
Advantage: 58

Shanghai Huikai Chemical Technology Co., Ltd.

Tel: 021-61995394 18916691159
Email: chemicalsea@163.com
Country: China
ProdList: 1972
Advantage: 58

Nanjing ShengSai Chemical Co., Ltd.

Tel: 025-85205967 13951876367
Fax: 025-85205967
Email: shengsaichem@163.com
Country: China
ProdList: 818
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Zhengzhou HongSheng Pharmaceutical Co., Ltd.

Tel: 0371-0371-13526885213 15637198702
Fax: 0371-63709726
Email: hsyykjchem@163.com
Country: China
ProdList: 3853
Advantage: 58

Credit-Chem Co., Ltd.

Tel: 400-821-5857 021-64326257
Fax: 021-64393586 QQ;2798200800
Email: credit-chem@foxmail.com
Country: China
ProdList: 5219
Advantage: 58

Shanghai ACT chemical Limited

Tel: 021-59904146 18001826933
Fax: +86-21-59904146
Email: sales@actchemical.com
Country: China
ProdList: 476
Advantage: 56

Tianjin Anhao Biological Technology Co., Ltd.

Tel
Email: sales@ahpharmatech.com
Country: China
ProdList: 5734
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14912
Advantage: 59

Shanghai Jovan Biochemical Technology Co. Ltd.

Tel: +86-021-61654350
Fax: +86-021-61654350
Email: 1245958370@qq.com
Country: China
ProdList: 2982
Advantage: 50

Changzhou Tianrui Pharmaceutical Technology Co., Ltd.

Tel: 0519-85386832 13382812559
Fax: 0519-85386832
Email: sales@cztrchem.com
Country: China
ProdList: 1185
Advantage: 56

Shanghai Song Yuan Chemical Technology Co., Ltd.

Tel: 010-1234567 18521000990
Fax: 86-021-33275113
Email: sonyuanchemical@163.com
Country: China
ProdList: 6479
Advantage: 50

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Bellen Chemistry Co., Ltd.

Tel: 010-60400365-8001 15910885229
Fax: 010-60400361
Email: service@bellenchem.com
Country: China
ProdList: 4514
Advantage: 60

Changzhou Anxuan Chemical, Co., Ltd.

Tel: 13912302692 13912302692;
Fax: 0519-88064678
Email: sales@anxuanchem.com
Country: China
ProdList: 4828
Advantage: 58

Zhengzhou KeYulong chemical products Co., Ltd

Tel: 17319789407 17319789407
Fax: 0371-53335504
Email: Keyulongchem@163.com
Country: China
ProdList: 1987
Advantage: 55

Chengdu Research Accelerators Technology Co., Ltd.

Tel: 028-64353063
Fax: 028-64353063 QQ:784253935
Email: reacchemical@163.com
Country: China
ProdList: 5253
Advantage: 58

Chengdu RunZeBenTu Chemical Co., Ltd

Tel: 028-88469284 18000562381
Email: rzbtsj@163.com
Country: China
ProdList: 9951
Advantage: 56

Less

View Lastest Price from 4,5-DIFLUORO-2-NITROANILINE manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 4,5-DIFLUORO-2-NITROANILINE 78056-39-0
Price: US $70.00-700.00/kg
Min. Order: 10kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-11-09

Career Henan Chemical Co

Product: 4,5-DIFLUORO-2-NITROANILINE 78056-39-0
Price: US $10.00/KG/Tin
Min. Order: 1KG
Purity: 99%
Supply Ability: 100
Release date: 2019-06-28

78056-39-0, 4,5-DIFLUORO-2-NITROANILINERelated Search:

4,5-DIFLUORO-2-NITROANILINE 2,3,4-Trifluoro-6-nitroaniline 2,5-Difluoro-4-Nitroaniline,2,5-Difluoro-4-Nitroaniline 2,4-DIFLUORO-6-NITROANILINE,2,4-DIFLUORO-6-NITROANILINE 2,3-Difluoro-6-nitroaniline98%,2,3-Difluoro-6-nitroaniline98% 3,5-DIFLUORO-4-NITROANILINE,3,5-DIFLUORO-4-NITROANILINE 3-Chloro-2,4-difluoro-6-nitroaniline,3-Chloro-2,4-difluoro-6-nitroaniline 3,5-DIFLUORO-2-NITROANILINE,3,5-DIFLUORO-2-NITROANILINE 4',5'-DIFLUORO-2'-NITROACETANILIDE 2,3-Difluoro-6-nitroaniline 98%,2,3-DIFLUORO-6-NITROANILINE,2,3-Difluoro-6-nitroaniline 98%,2,3-DIFLUORO-6-NITROANILINE 2,4-DIFLUORO-5-NITROANILINE,2,4-DIFLUORO-5-NITROANILINE 2,6-difluoro-3-nitroaniline,2,6-difluoro-3-nitroaniline 2,6-DIFLUORO-4-NITROANILINE,2,6-DIFLUORO-4-NITROANILINE 1-(4,5-difluoro-2-nitrophenyl)hydrazine 2-NITROTETRAFLUOROANILINE N1-(2,3,4-TRIFLUORO-6-NITROPHENYL)ACETAMIDE

4,5-DIFLUORO-2-NITROANILINE

3,4-DIFLUORO-2-NITROANILINE

3,4-DIFLUORO-6-NITRO ANILINE

BUTTPARK 19\04-57

4,5-DIFLUORO-2-NITROANILINE 99%

4,5-DIFLUORO-2-NITRO

2-Amino-4,5-difluoronitrobenzene

4,5-Difluoro-2-nitroaniline,98%

4,5-Difluoro-2-nitroaniline[2-AMino-4,5-difluoronitrobenzene]

4,5-Difluoro-2-nitro-phenylamine

2-Amino-4,5-diflu

4,5-Difluoro-2-nitroaniline&gt

4,5-DifL

Benzenamine, 4,5-difluoro-2-nitro-

4,5-DIFLUORO-2-NITROANILINE ISO 9001：2015 REACH

78056-39-0

C6H4F2N2O2

F2C6H2NO2NH2

AMINE

Building Blocks

Amines

C2 to C6

Nitrogen Compounds

Organic Building Blocks

Aryl Fluorinated Building Blocks

Building Blocks

Chemical Synthesis

Fluorinated Building Blocks

Nitrogen Compounds

Organic Building Blocks

Organic Fluorinated Building Blocks

Other Fluorinated Organic Building Blocks

Aniline

Miscellaneous

Anilines, Amides & Amines

Fluorine Compounds

Nitro Compounds

Amines

C2 to C6

Nitrogen Compounds