beta-Hydroxyisovaleric Acid
- Product Name
- beta-Hydroxyisovaleric Acid
- CAS No.
- 625-08-1
- Chemical Name
- beta-Hydroxyisovaleric Acid
- Synonyms
- 3-Hydroxyisovaleric acid;3-HYDROXY-3-METHYLBUTANOIC ACID;3-HYDROXY-3-METHYL BUTYRIC ACID;β-Hydroxyisovaleric Acid;BETA-HYDROXY BETA-METHYLBUTYRATE;RARECHEM AL BO 2324;3-OH-isovaleric acid;HYDROXY-METHYLBUTYRATE;3-hydroxyisovalericaci;?Hydroxyisovaleric acid
- CBNumber
- CB3213104
- Molecular Formula
- C5H10O3
- Formula Weight
- 118.13
- MOL File
- 625-08-1.mol
beta-Hydroxyisovaleric Acid Property
- Melting point:
- -80 °C (lit.)
- Boiling point:
- 88 °C/1 mmHg (lit.)
- Density
- 0.938 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.4415(lit.)
- Flash point:
- 113 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMF:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
DMSO:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
Ethanol:10.0(Max Conc. mg/mL);84.65(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);84.65(Max Conc. mM) - pka
- 4.38±0.10(Predicted)
- form
- Liquid
- Specific Gravity
- 1.10
- color
- Pale yellow
- Water Solubility
- Soluble in water and ethanol.
- BRN
- 1743952
- InChIKey
- AXFYFNCPONWUHW-UHFFFAOYSA-N
- CAS DataBase Reference
- 625-08-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 55453
- Product name
- β-Hydroxyisovaleric acid
- Purity
- ≥95.0% (T)
- Packaging
- 1g
- Price
- $574
- Updated
- 2024/03/01
- Product number
- H0701
- Product name
- β-Hydroxyisovaleric Acid
- Purity
- >96.0%(GC)(T)
- Packaging
- 5g
- Price
- $88
- Updated
- 2024/03/01
- Product number
- H0701
- Product name
- β-Hydroxyisovaleric Acid
- Purity
- >96.0%(GC)(T)
- Packaging
- 25g
- Price
- $293
- Updated
- 2024/03/01
- Product number
- 042722
- Product name
- 3-Hydroxy-3-methylbutyric acid, 96%
- Packaging
- 10g
- Price
- $42.7
- Updated
- 2024/03/01
- Product number
- 042722
- Product name
- 3-Hydroxy-3-methylbutyric acid, 96%
- Packaging
- 1kg
- Price
- $1323
- Updated
- 2021/12/16
beta-Hydroxyisovaleric Acid Chemical Properties,Usage,Production
Description
β-Hydroxy β-methylbutyric acid (HMB), or β-hydroxy β- methylbutyrate, is a metabolite of the essential amino acid leucine and is synthesized in the human body. It plays a part in protein synthesis and was discovered by Dr. Steven L. Nissen at Iowa State University. It has been used in scientific studies to purportedly increase muscle mass and decrease muscle breakdown. Nissen held the original patent on the metabolite as a nutritional supplement. It was discovered in pigs, and small quantities can also be found in grapefruit, alfalfa, and catfish. As a supplement it is usually sold as a calcium salt.
Research published in the Journal of Applied Physiology has shown that HMB may have an effect on increasing muscle weight and strength. A review in Nutrition & Metabolism provides an in depth and objective analysis of HMB research. The same study lists as HMB' s proposed mechanisms of action the following:
Increased sarcolemmal integrity via conversion to HMG-CoA
Enhanced protein synthesis via the mTOR pathway
Depression of protein degradation through inhibition of the ubiquitin pathway
Three grams of Calcium beta-hydroxy-beta-methylbutyrate per day may help muscles combat protein breakdown, assist in muscle repair and support increased endurance. Studies suggest its benefits may be greater for the untrained. Also, well-controlled scientific studies have found increases in muscle mass and decreases in body fat in 70 year old men. It has helped patients with chronic obstructive pulmonary disease in hospital intensive care units, muscle wasting associated with HIV or AIDS and with cancer, and trauma victims with severe injuries.
The human body produces about 0.2 - 0.4 grams per day. Standard doses in research studies have been 1.5 to 3.0 grams per day, usually divided into two doses.
Chemical Properties
colorless to light yellow liquid
Uses
β-Hydroxyisovaleric Acid is a metabolite of the essential amino acid Leucine and is synthesized in the human body. Studies suggest that β-Hydroxyisovaleric Acid may have an effect on increasing muscle weight and strength. The presence of elevated β-Hydroxyisovaleric Acid is a sensitive marker of biotin deficiency and may indicate the presence of a genetic disorder such as biotinidase deficiency or holocarboxylase synthetase deficiency.
Uses
3-Hydroxy-3-methylbutyric acid is a useful biochemical for synthesis and proteomics research. It is used as an indicator of biotin deficiency. Further, it is used to increase muscle mass and decrease muscle breakdown. In addition to this, it is involved in the protein synthesis.
Definition
ChEBI: A 3-hydroxy monocarboxylic acid that is isovaleric acid substituted at position 3 by a hydroxy group. Used as indicator of biotin deficiency.
beta-Hydroxyisovaleric Acid Preparation Products And Raw materials
Raw materials
Preparation Products
beta-Hydroxyisovaleric Acid Suppliers
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- Country
- United Kingdom
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- 5618
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- United Kingdom
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- United Kingdom
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- solutions@vwr.com
- Country
- United Kingdom
- ProdList
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View Lastest Price from beta-Hydroxyisovaleric Acid manufacturers
- Product
- 3-Hydroxyisovaleric acid 625-08-1
- Price
- US $100.00-45.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-05-07
- Product
- beta-Hydroxyisovaleric Acid 625-08-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 500kg/month
- Release date
- 2021-10-25
- Product
- beta-Hydroxyisovaleric Acid 625-08-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-18