3-HYDROXY-3-METHYLGLUTARIC ACID

Product Name: 3-HYDROXY-3-METHYLGLUTARIC ACID
CAS No.: 503-49-1
Chemical Name: 3-HYDROXY-3-METHYLGLUTARIC ACID
Synonyms: Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1
CBNumber: CB1454369
Molecular Formula: C6H10O5
Formula Weight: 162.14
MOL File: 503-49-1.mol

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3-HYDROXY-3-METHYLGLUTARIC ACID Property

Melting point:: 105-108 °C (lit.)
Boiling point:: 120 °C / 13mmHg
Density: 1.2132 (rough estimate)
refractive index: 1.4230 (estimate)
storage temp.: -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
pka: 3.95±0.10(Predicted)
form: powder to crystal
color: White to Light yellow
Merck: 14,5808
BRN: 1769194
CAS DataBase Reference: 503-49-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-24/25-36-26
WGK Germany: 2
RTECS: MA3753000
F: 10
HS Code: 29181990
Toxicity: LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: H4392
Product name: 3-Hydroxy-3-methylglutaric acid
Purity: ≥95%
Packaging: 100mg
Price: $153
Updated: 2024/03/01

Sigma-Aldrich

Product number: H4392
Product name: 3-Hydroxy-3-methylglutaric acid
Purity: ≥95%
Packaging: 1g
Price: $696
Updated: 2024/03/01

Sigma-Aldrich

Product number: 91387
Product name: 3-Hydroxy-3-methylglutaric acid
Purity: analytical standard
Packaging: 10MG
Price: $63.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 91387
Product name: 3-Hydroxy-3-methylglutaric acid
Purity: analytical standard
Packaging: 50MG
Price: $113
Updated: 2022/05/15

TCI Chemical

Product number: H0436
Product name: 3-Hydroxy-3-methylglutaric Acid
Purity: >95.0%(T)
Packaging: 100mg
Price: $250
Updated: 2024/03/01

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3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties,Usage,Production

Description

Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.

Chemical Properties

White Solid

Originator

Aligarh Muslim Univ. (India)

Uses

antihyperlipoproteinemia

Uses

3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.

Definition

ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.

brand name

LIPOGLUTAREN

Synthesis Reference(s)

Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596

Purification Methods

Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]

3-HYDROXY-3-METHYLGLUTARIC ACID Preparation Products And Raw materials

Raw materials

Potassium hydroxide Hydrogen peroxide Sodium sulfate Tetrahydrofuran Diethyl ether Ethyl acetate Dichloromethane Allyl bromide Acetic acid Magnesium Sulfuric acid

Preparation Products

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3-HYDROXY-3-METHYLGLUTARIC ACID Suppliers

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View Lastest Price from 3-HYDROXY-3-METHYLGLUTARIC ACID manufacturers

Career Henan Chemical Co

Product: 3-HYDROXY-3-METHYLGLUTARIC ACID 503-49-1
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-09

503-49-1, 3-HYDROXY-3-METHYLGLUTARIC ACIDRelated Search:

Piperazine citrate Lead citrate Ammonium citrate tribasic Disodium citrate Choline dihydrogencitrate salt SODIUM DIHYDROGEN CITRATE Sodium citrate 3-HYDROXY-3-METHYLGLUTARIC ACID Triethyl citrate Alverine citrate 1,2,3-Propanetricarboxylicacid,2-hydroxy-,potassiumsalt Acetyl tributyl citrate oxeladin Ammonium ferric citrate Trimagnesium dicitrate TRIMETHYL CITRATE AMMONIUM BISMUTH CITRATE FERRIC CITRATE

hmga

lipoglutaren

medroglutaricacid

3-Hydroxymethylglutaric acid

Meglutol

3-HYDROXY-3-METHYLPENTANEDIOIC ACID (HMG)

3-Hydroxy-3-methylglutaric acid ,98%

3-Hydroxy-3-Methylglutaric acid >=95%

3-HYDROXY-3-METHYLGLUTARIC ACID

3-HYDROXY-3-METHYLPENTANEDIOIC ACID

AKOS 91366

DICROTALIC ACID

B-METHYL-B-HYDROXYGLUTARIC ACID

B-HYDROXY-B-METHYLGLUTARIC ACID

3-hydroxy-3-methyl-glutaricaci

beta-hydroxy-beta-methylglutaricacid

cb-337

3-Hydroxy-3-methylglutaricAcid&gt

3-HYDROXY-3-METHYLPENTANE-1

Pentanedioic acid, 3-hydroxy-3-methyl-

3-HYDROXY-3-METHYLGLUTARIC ACID USP/EP/BP

3-Hydroxy-3-methylpentanedioic acid[Dicrotalic Acid

3-Hydroxy-3-methyl-pentanedioic acid, 98+%

Autophagy,inhibit,Meglutol,Endogenous Metabolite,Inhibitor,HMG-CoA Reductase (HMGCR)

Adipic acid impurity3（Meglutto）

503-49-1

1461426

HOCCH3CH2CO2H2

Organic Building Blocks

C6

Carboxylic Acids

Carbonyl Compounds

Building Blocks

Miscellaneous Reagents

Building Blocks

C6

Carbonyl Compounds

Carboxylic Acids

Chemical Synthesis

Organic Building Blocks

Pharmaceutical Raw Materials