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3-HYDROXY-3-METHYLGLUTARIC ACID

Product Name
3-HYDROXY-3-METHYLGLUTARIC ACID
CAS No.
503-49-1
Chemical Name
3-HYDROXY-3-METHYLGLUTARIC ACID
Synonyms
Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1
CBNumber
CB1454369
Molecular Formula
C6H10O5
Formula Weight
162.14
MOL File
503-49-1.mol
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3-HYDROXY-3-METHYLGLUTARIC ACID Property

Melting point:
105-108 °C (lit.)
Boiling point:
120 °C / 13mmHg
Density 
1.2132 (rough estimate)
refractive index 
1.4230 (estimate)
storage temp. 
-20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
pka
3.95±0.10(Predicted)
form 
powder to crystal
color 
White to Light yellow
Merck 
14,5808
BRN 
1769194
CAS DataBase Reference
503-49-1(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-36-26
WGK Germany 
2
RTECS 
MA3753000
10
HS Code 
29181990
Toxicity
LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H4392
Product name
3-Hydroxy-3-methylglutaric acid
Purity
≥95%
Packaging
100mg
Price
$153
Updated
2024/03/01
Sigma-Aldrich
Product number
H4392
Product name
3-Hydroxy-3-methylglutaric acid
Purity
≥95%
Packaging
1g
Price
$696
Updated
2024/03/01
Sigma-Aldrich
Product number
91387
Product name
3-Hydroxy-3-methylglutaric acid
Purity
analytical standard
Packaging
10MG
Price
$63.3
Updated
2024/03/01
Sigma-Aldrich
Product number
91387
Product name
3-Hydroxy-3-methylglutaric acid
Purity
analytical standard
Packaging
50MG
Price
$113
Updated
2022/05/15
TCI Chemical
Product number
H0436
Product name
3-Hydroxy-3-methylglutaric Acid
Purity
>95.0%(T)
Packaging
100mg
Price
$250
Updated
2024/03/01
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3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties,Usage,Production

Description

Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.

Chemical Properties

White Solid

Originator

Aligarh Muslim Univ. (India)

Uses

antihyperlipoproteinemia

Uses

3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.

Definition

ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.

brand name

LIPOGLUTAREN

Synthesis Reference(s)

Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596

Purification Methods

Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]

3-HYDROXY-3-METHYLGLUTARIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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3-HYDROXY-3-METHYLGLUTARIC ACID Suppliers

J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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China
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TCI (Shanghai) Development Co., Ltd.
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Maya High Purity Chemicals
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+86 (573) 82222445 (0)18006601000 452520369
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+86 (573) 82222643
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sales@maya-r.com
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China
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Spectrum Chemical Manufacturing Corp.
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021-021-021-67601398-809-809-809 15221380277
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021-57711696
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View Lastest Price from 3-HYDROXY-3-METHYLGLUTARIC ACID manufacturers

Career Henan Chemical Co
Product
3-HYDROXY-3-METHYLGLUTARIC ACID 503-49-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

503-49-1, 3-HYDROXY-3-METHYLGLUTARIC ACIDRelated Search:


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