3-HYDROXY-3-METHYLGLUTARIC ACID
- Product Name
- 3-HYDROXY-3-METHYLGLUTARIC ACID
- CAS No.
- 503-49-1
- Chemical Name
- 3-HYDROXY-3-METHYLGLUTARIC ACID
- Synonyms
- Meglutol;3-Hydroxymethylglutaric acid;3-HYDROXY-3-METHYLPENTANEDIOIC ACID;lipoglutaren;DICROTALIC ACID;hmga;cb-337;AKOS 91366;medroglutaricacid;3-HYDROXY-3-METHYLPENTANE-1
- CBNumber
- CB1454369
- Molecular Formula
- C6H10O5
- Formula Weight
- 162.14
- MOL File
- 503-49-1.mol
3-HYDROXY-3-METHYLGLUTARIC ACID Property
- Melting point:
- 105-108 °C (lit.)
- Boiling point:
- 120 °C / 13mmHg
- Density
- 1.2132 (rough estimate)
- refractive index
- 1.4230 (estimate)
- storage temp.
- -20°C
- solubility
- DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 5 mg/ml; PBS (pH 7.2): 10 mg/ml
- pka
- 3.95±0.10(Predicted)
- form
- powder to crystal
- color
- White to Light yellow
- Merck
- 14,5808
- BRN
- 1769194
- CAS DataBase Reference
- 503-49-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 22-24/25-36-26
- WGK Germany
- 2
- RTECS
- MA3753000
- F
- 10
- HS Code
- 29181990
- Toxicity
- LD50 in mice (g/kg): 7.33 orally; 3.23 i.p. (Savoie, Lupien)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- H4392
- Product name
- 3-Hydroxy-3-methylglutaric acid
- Purity
- ≥95%
- Packaging
- 100mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- H4392
- Product name
- 3-Hydroxy-3-methylglutaric acid
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $696
- Updated
- 2024/03/01
- Product number
- 91387
- Product name
- 3-Hydroxy-3-methylglutaric acid
- Purity
- analytical standard
- Packaging
- 10MG
- Price
- $63.3
- Updated
- 2024/03/01
- Product number
- 91387
- Product name
- 3-Hydroxy-3-methylglutaric acid
- Purity
- analytical standard
- Packaging
- 50MG
- Price
- $113
- Updated
- 2022/05/15
- Product number
- H0436
- Product name
- 3-Hydroxy-3-methylglutaric Acid
- Purity
- >95.0%(T)
- Packaging
- 100mg
- Price
- $250
- Updated
- 2024/03/01
3-HYDROXY-3-METHYLGLUTARIC ACID Chemical Properties,Usage,Production
Description
Meglutol (β-hydroxy-β-methylglutaric acid; HMG) is a hypolipidemic agent that acts via the inhibition of cholesterol synthesis a t the stage of HMG-CoAreductase, blocking the conversion of HMG-CoA to mevalonate. This conversion is the rate-limiting step in cholesterol biosynthesis and is the point of physiological feedback control; as such, it appears to be the ideal locus of action for a hypolipidemic agent. Investigational compounds that act by this mechanism include the natural products compactin and mevinolin.
Chemical Properties
White Solid
Originator
Aligarh Muslim Univ. (India)
Uses
antihyperlipoproteinemia
Uses
3-Hydroxy-3-methylpentane-1,5-dioic Acid (cas# 503-49-1) is a compound useful in organic synthesis.
Definition
ChEBI: A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.
brand name
LIPOGLUTAREN
Synthesis Reference(s)
Synthesis, p. 791, 1981 DOI: 10.1055/s-1981-29596
Purification Methods
Recrystallise the acid from diethyl ether/hexane and dry it under avacuum at 60o for 1hour. [Beilstein 3 IV 1166.]
3-HYDROXY-3-METHYLGLUTARIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
3-HYDROXY-3-METHYLGLUTARIC ACID Suppliers
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View Lastest Price from 3-HYDROXY-3-METHYLGLUTARIC ACID manufacturers
- Product
- 3-HYDROXY-3-METHYLGLUTARIC ACID 503-49-1
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-09