Acetyl tributyl citrate
- Product Name
- Acetyl tributyl citrate
- CAS No.
- 77-90-7
- Chemical Name
- Acetyl tributyl citrate
- Synonyms
- ATBC;TRIBUTYL ACETYLCITRATE;Acetyltributylcitrat;TRIBUTYL O-ACETYLCITRATE;Tributyl citrate acetate;citroflexa4;Acetyl butyl citrate;tributylcitrateacetate;ACETYL TRI-N-BUTYL CITRATE;tributyl 2-acetoxypropane-1,2,3-tricarboxylate
- CBNumber
- CB0408022
- Molecular Formula
- C20H34O8
- Formula Weight
- 402.48
- MOL File
- 77-90-7.mol
Acetyl tributyl citrate Property
- Melting point:
- -59 °C
- Boiling point:
- 327 °C
- Density
- 1.05 g/mL at 25 °C (lit.)
- Pour Point
- -43
- vapor pressure
- 0.26 psi ( 20 °C)
- refractive index
- n20/D 1.443(lit.)
- FEMA
- 3080 | TRIBUTYL ACETYLCITRATE
- Flash point:
- >230 °F
- storage temp.
- Store below +30°C.
- solubility
- Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
- form
- Liquid
- color
- Clear Colourless
- Odor
- at 100.00 %. very faint herbal wine sweet
- Odor Type
- herbal
- Water Solubility
- <0.1 g/100 mL
- FreezingPoint
- -80℃
- JECFA Number
- 630
- BRN
- 2303316
- InChIKey
- QZCLKYGREBVARF-UHFFFAOYSA-N
- LogP
- 5.227 (est)
- CAS DataBase Reference
- 77-90-7(CAS DataBase Reference)
- NIST Chemistry Reference
- 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
- EPA Substance Registry System
- Acetyl tributyl citrate (77-90-7)
Safety
- Safety Statements
- 24/25
- WGK Germany
- 3
- RTECS
- TZ8330000
- TSCA
- TSCA listed
- HS Code
- 29181500
- Hazardous Substances Data
- 77-90-7(Hazardous Substances Data)
N-Bromosuccinimide Price
- Product number
- 1009901
- Product name
- Acetyltributyl citrate
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 500mg
- Price
- $450
- Updated
- 2022/05/15
- Product number
- A0822
- Product name
- Tributyl O-Acetylcitrate
- Purity
- >97.0%(GC)
- Packaging
- 25mL
- Price
- $17
- Updated
- 2024/03/01
- Product number
- A0822
- Product name
- Tributyl O-Acetylcitrate
- Purity
- >97.0%(GC)
- Packaging
- 500mL
- Price
- $54
- Updated
- 2024/03/01
- Product number
- P-107
- Product name
- Acetyl tri-n-butyl citrate
- Packaging
- 100g
- Price
- $14
- Updated
- 2024/07/03
- Product number
- P-107
- Product name
- Acetyl tri-n-butyl citrate
- Packaging
- 250g
- Price
- $28
- Updated
- 2024/07/03
Acetyl tributyl citrate Chemical Properties,Usage,Production
Chemical Properties
clear colorless liquid
Chemical Properties
Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.
Chemical Properties
Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.
Chemical Properties
Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.
Uses
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Uses
Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.
Uses
plasticizer flavoring agent
Preparation
From citric acid via the tributyl ester followed by acetylation.
Production Methods
Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.
Definition
Aqueous-based pharmaceutical coat- ings.
Taste threshold values
An emulsion of the title material in water at 1000 ppm has only a very faint, mildly fruity-winey, berry-like odor and a mild, nondescript taste.
General Description
Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Pharmaceutical Applications
Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.
Safety Profile
When heated to decomposition it emits acrid smoke and irritating fumes. ADD750
Safety
and films intended for direct food contact. It is also used in selfadhesive
thin films used for topical delivery systems. It is generally
regarded as a relatively nontoxic and nonirritating material.
However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg
Carcinogenicity
The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.
Solubility in organics
Miscible with alcohol and oils.
storage
Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.
Incompatibilities
Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.
Regulatory Status
Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.
Acetyl tributyl citrate Preparation Products And Raw materials
Raw materials
Preparation Products
Acetyl tributyl citrate Suppliers
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View Lastest Price from Acetyl tributyl citrate manufacturers
- Product
- ACETYL TRIBUTYL CITRATE 77-90-7
- Price
- US $770.00/kg
- Min. Order
- 1000kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-05-21
- Product
- Acetyl tributyl citrate 77-90-7
- Price
- US $100.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-04-28
- Product
- butyl acetylcitrate 77-90-7
- Price
- US $60.00/kg
- Min. Order
- 1kg
- Purity
- 99
- Supply Ability
- 5000
- Release date
- 2024-05-17