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Acetyl tributyl citrate

Product Name
Acetyl tributyl citrate
CAS No.
77-90-7
Chemical Name
Acetyl tributyl citrate
Synonyms
ATBC;Blo-trol;Estaflex;FEMA 3080;Uniplex 84;citroflexa;Citroflex A;citroflexa4;Citroflex A 4;acetylbutylcitrate
CBNumber
CB0408022
Molecular Formula
C20H34O8
Formula Weight
402.48
MOL File
77-90-7.mol
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Acetyl tributyl citrate Property

Melting point:
-59 °C
Boiling point:
327 °C
Density 
1.05 g/mL at 25 °C (lit.)
vapor pressure 
0.26 psi ( 20 °C)
refractive index 
n20/D 1.443(lit.)
FEMA 
3080 | TRIBUTYL ACETYLCITRATE
Flash point:
>230 °F
storage temp. 
Store below +30°C.
solubility 
Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
form 
neat
Water Solubility 
<0.1 g/100 mL
FreezingPoint 
-80℃
JECFA Number
630
BRN 
2303316
InChIKey
QZCLKYGREBVARF-UHFFFAOYSA-N
CAS DataBase Reference
77-90-7(CAS DataBase Reference)
NIST Chemistry Reference
1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
EPA Substance Registry System
Acetyl tributyl citrate (77-90-7)
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Safety

Safety Statements 
24/25
WGK Germany 
3
RTECS 
TZ8330000
HS Code 
29181500
Hazardous Substances Data
77-90-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
8.14437
Product name
Tributylacetyl citrate
Purity
for synthesis
Packaging
100 mL
Price
$25.53
Updated
2021/03/22
Sigma-Aldrich
Product number
Y0001055
Product name
Tributyl acetylcitrate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1009901
Product name
Acetyltributyl citrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$358
Updated
2020/08/18
Sigma-Aldrich
Product number
1009901
Product name
Acetyltributyl citrate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$425
Updated
2020/08/18
TCI Chemical
Product number
A0822
Product name
Tributyl O-Acetylcitrate
Purity
>97.0%(GC)
Packaging
25mL
Price
$15
Updated
2021/03/22
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Acetyl tributyl citrate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Chemical Properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical Properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Chemical Properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

Uses

Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

Uses

plasticizer flavoring agent

Definition

Aqueous-based pharmaceutical coat- ings.

Preparation

From citric acid via the tributyl ester followed by acetylation.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

Safety

and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): >4 g/kg
LD50 (rat, oral): >31.5 g/kg

Carcinogenicity

The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

storage

Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

Incompatibilities

Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Acetyl tributyl citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Acetyl tributyl citrate Suppliers

Ji 'nan jinbang environmental protection technology co., ltd
Tel
; ;
Email
3306388863@qq.com;3306388863@qq.com;3306388863@qq.com
Country
China
ProdList
29
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
21-61259100-
Fax
86-21-61259102
Email
sh@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057-
Fax
0757-86311057
Email
sales.gd@hwrkchemical.com
Country
China
ProdList
17295
Advantage
55
Energy Chemical
Tel
021-58432009-
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
43498
Advantage
61
Adamas Reagent, Ltd.
Tel
400-600-9262
Email
bxy@titansci.com
Country
China
ProdList
13915
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202- ; ;
Email
jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com;jerry.ma@hanhonggroup.com
Country
China
ProdList
43255
Advantage
64
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
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View Lastest Price from Acetyl tributyl citrate manufacturers

Wuhan wingroup Pharmaceutical Co., Ltd
Product
Acetyl tributyl citrate 77-90-7
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-07-08
Wuhan Monad Medicine Tech Co.,LTD
Product
Acetyl tributyl citrate 77-90-7
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%min
Supply Ability
2000
Release date
2021-04-16
Hebei Crovell Biotech Co Ltd
Product
Acetyl Tributyl Citrate 77-90-7
Price
US $5.70/Kg/Drum
Min. Order
10g
Purity
99%
Supply Ability
10000kg
Release date
2021-06-29

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