Mosapride citrate
- Product Name
- Mosapride citrate
- CAS No.
- 112885-42-4
- Chemical Name
- Mosapride citrate
- Synonyms
- as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapridecitrate/TAK-370citrate/AS-4370citrate
- CBNumber
- CB6696030
- Molecular Formula
- C27H33ClFN3O10
- Formula Weight
- 614.02
- MOL File
- 112885-42-4.mol
Mosapride citrate Property
- Melting point:
- 143-145°
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Ethanol (Slightly, Sonicated)
- form
- Solid
- color
- White to Off-White
- Stability:
- Hygroscopic
- CAS DataBase Reference
- 112885-42-4(CAS DataBase Reference)
Safety
- Toxicity
- LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- 30048
- Product name
- Mosapride (citrate)
- Packaging
- 10mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 30048
- Product name
- Mosapride (citrate)
- Packaging
- 250mg
- Price
- $887
- Updated
- 2024/03/01
- Product number
- 30048
- Product name
- Mosapride (citrate)
- Packaging
- 50mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- 30048
- Product name
- Mosapride (citrate)
- Packaging
- 100mg
- Price
- $384
- Updated
- 2024/03/01
- Product number
- 2844
- Product name
- Mosapridecitrate
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $459
- Updated
- 2021/12/16
Mosapride citrate Chemical Properties,Usage,Production
Description
Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.
Uses
Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.
Uses
As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.
Biological Activity
5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.
storage
room temperature (desiccate)
Mosapride citrate Preparation Products And Raw materials
Raw materials
Preparation Products
Mosapride citrate Suppliers
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View Lastest Price from Mosapride citrate manufacturers
- Product
- Mosapride citrate 112885-42-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 500kg/month
- Release date
- 2021-07-23
- Product
- Mosapride citrate 112885-42-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-19
- Product
- Mosapride citrate 112885-42-4
- Price
- US $10.00/Kg/Bag
- Min. Order
- 1Kg/Bag
- Purity
- 99%
- Supply Ability
- 20 Tons
- Release date
- 2021-11-03