3-Hydroxyazetidine hydrochloride

Product Name: 3-Hydroxyazetidine hydrochloride
CAS No.: 18621-18-6
Chemical Name: 3-Hydroxyazetidine hydrochloride
Synonyms: AZETIDIN-3-OL HYDROCHLORIDE;3-AZETIDINOL HYDROCHLORIDE;3-HYDROXYAZETIDINE HCL;Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride;AZETAN-2-ONE;BUTTPARK 75\04-67;Azetidine-3-ol.Hcl;Baricitinib-009-HCl;3-hydroxyazatidine HCl;3-Hydroxyl-azetidine HCl
CBNumber: CB0455455
Molecular Formula: C3H8ClNO
Formula Weight: 109.55
MOL File: 18621-18-6.mol

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3-Hydroxyazetidine hydrochloride Property

Melting point:: 85-90 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Water Solubility: Soluble in water, DMSO, methanol.
Sensitive: Hygroscopic
Stability:: Hygroscopic
InChI: InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H
InChIKey: UQUPQEUNHVVNKW-UHFFFAOYSA-N
SMILES: C1(O)CNC1.Cl
CAS DataBase Reference: 18621-18-6(CAS DataBase Reference)

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Safety

Hazard Codes: C,Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39
RIDADR: UN1759
WGK Germany: 3
Hazard Note: Harmful/Corrosive
HazardClass: IRRITANT
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 680079
Product name: 3-Hydroxyazetidine hydrochloride
Purity: 97%
Packaging: 1g
Price: $53.9
Updated: 2024/03/01

Sigma-Aldrich

Product number: 680079
Product name: 3-Hydroxyazetidine hydrochloride
Purity: 97%
Packaging: 5g
Price: $117.6
Updated: 2024/03/01

TCI Chemical

Product number: H1264
Product name: 3-Hydroxyazetidine Hydrochloride
Purity: >98.0%(N)
Packaging: 1g
Price: $46
Updated: 2024/03/01

TCI Chemical

Product number: H1264
Product name: 3-Hydroxyazetidine Hydrochloride
Purity: >98.0%(N)
Packaging: 5g
Price: $137
Updated: 2024/03/01

Alfa Aesar

Product number: H25842
Product name: 3-Hydroxyazetidine hydrochloride, 97%
Packaging: 1g
Price: $84.65
Updated: 2024/03/01

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3-Hydroxyazetidine hydrochloride Chemical Properties,Usage,Production

Description

3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.

Chemical Properties

white crystal

Uses

3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.

Synthesis

A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).

3-Hydroxyazetidine hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Palladium Ethyl acetate Benzhydrylamine Hydrochloric acid Methanol Epichlorohydrin Isopropyl alcohol Sodium carbonate

Preparation Products

1-N-Boc-3-hydroxyazetidine 1-Boc-3-(Amino)azetidine

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3-Hydroxyazetidine hydrochloride Suppliers

Americas 1 Austria 1 Canada 1 China 410 Europe 2 France 1 Germany 7 India 23 Italy 1 Japan 2 Russia 1 Switzerland 1 United Kingdom 17 United States 55 Global 523

BTC Pharmaceutical CO. Ltd

Tel: 0513-0513-68015397 18862996710
Fax: 0513-68015394
Email: sales12@btcpharm.com
Country: China
ProdList: 689
Advantage: 55

Lianyungang Shengfeng Chemical Co., Ltd.

Tel: 0518-88223188 13906148196
Fax: 0518-88223199
Email: 13906148196@126.com
Country: China
ProdList: 1
Advantage: 58

Shanghai Sagachem Co., Ltd.

Tel: 13816115801
Email: raochenaone@126.com
Country: China
ProdList: 198
Advantage: 58

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Fax: +86-556-5032307
Email: wtx@bayeebio.com
Country: China
ProdList: 259
Advantage: 61

ANHUI JINGKE BIOTECHNOLOGY CO.,LTD

Tel: 0551-65206518 18133676923
Email: taozz@kingobiotech.com
Country: China
ProdList: 91
Advantage: 58

Lianhe Aigen Pharmatech Co.,Ltd.

Tel: 18918657159
Email: sales-Aigen@lianhetech.com
Country: China
ProdList: 3014
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J & K SCIENTIFIC LTD.

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Fax: 86-10-82849933
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PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
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Country: China
ProdList: 4986
Advantage: 55

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
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Country: China
ProdList: 40228
Advantage: 62

INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3572
Advantage: 66

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View Lastest Price from 3-Hydroxyazetidine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: 3-Hydroxyazetidine hydrochloride 18621-18-6
Price: US $200.00-95.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-04-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 3-Hydroxyazetidine hydrochloride 18621-18-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-02-02

Hebei Yanxi Chemical Co., Ltd.

Product: 3-Hydroxyazetidine hydrochloride 18621-18-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-08

18621-18-6, 3-Hydroxyazetidine hydrochlorideRelated Search:

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3-Hydroxyl-azetidine HCl

Baricitinib Impurity 11 HCl

Baricitinib Impurity 2 HCl

18621-18-6

8621-18-6

C3H7ClNO

C3H8NOCl

C3H7NOHCl

C3H7NOClH

Azetidines

Amino Acids & Derivatives

Heterocyclic Building Blocks

N-Containing

Others

B-Amino

Amino Acids 13C, 2H, 15N

pharmacetical

Azetidine

Alcohols and Derivatives

Heterocycles