ChemicalBook > CAS DataBase List > 3-Hydroxyazetidine hydrochloride

3-Hydroxyazetidine hydrochloride

Product Name
3-Hydroxyazetidine hydrochloride
CAS No.
18621-18-6
Chemical Name
3-Hydroxyazetidine hydrochloride
Synonyms
AZETIDIN-3-OL HYDROCHLORIDE;3-AZETIDINOL HYDROCHLORIDE;3-HYDROXYAZETIDINE HCL;Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride;AZETAN-2-ONE;BUTTPARK 75\04-67;Azetidine-3-ol.Hcl;Baricitinib-009-HCl;3-hydroxyazatidine HCl;3-Hydroxyl-azetidine HCl
CBNumber
CB0455455
Molecular Formula
C3H8ClNO
Formula Weight
109.55
MOL File
18621-18-6.mol
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3-Hydroxyazetidine hydrochloride Property

Melting point:
85-90 °C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water, DMSO, methanol.
Sensitive 
Hygroscopic
Stability:
Hygroscopic
InChI
InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H
InChIKey
UQUPQEUNHVVNKW-UHFFFAOYSA-N
SMILES
C1(O)CNC1.Cl
CAS DataBase Reference
18621-18-6(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xi,Xn
Risk Statements 
36/37/38-41-37/38-22
Safety Statements 
26-36/37/39
RIDADR 
UN1759
WGK Germany 
3
Hazard Note 
Harmful/Corrosive
HazardClass 
IRRITANT
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
680079
Product name
3-Hydroxyazetidine hydrochloride
Purity
97%
Packaging
1g
Price
$53.9
Updated
2024/03/01
Sigma-Aldrich
Product number
680079
Product name
3-Hydroxyazetidine hydrochloride
Purity
97%
Packaging
5g
Price
$117.6
Updated
2024/03/01
TCI Chemical
Product number
H1264
Product name
3-Hydroxyazetidine Hydrochloride
Purity
>98.0%(N)
Packaging
1g
Price
$46
Updated
2024/03/01
TCI Chemical
Product number
H1264
Product name
3-Hydroxyazetidine Hydrochloride
Purity
>98.0%(N)
Packaging
5g
Price
$137
Updated
2024/03/01
Alfa Aesar
Product number
H25842
Product name
3-Hydroxyazetidine hydrochloride, 97%
Packaging
1g
Price
$84.65
Updated
2024/03/01
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3-Hydroxyazetidine hydrochloride Chemical Properties,Usage,Production

Description

3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.

Chemical Properties

white crystal

Uses

3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.

Synthesis

A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).

3-Hydroxyazetidine hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol Palladium Ethyl acetate Benzhydrylamine Hydrochloric acid Methanol Epichlorohydrin Isopropyl alcohol Sodium carbonate

Preparation Products

1-N-Boc-3-hydroxyazetidine 1-Boc-3-(Amino)azetidine
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3-Hydroxyazetidine hydrochloride Suppliers

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View Lastest Price from 3-Hydroxyazetidine hydrochloride manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
3-Hydroxyazetidine hydrochloride 18621-18-6
Price
US $200.00-95.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
3-Hydroxyazetidine hydrochloride 18621-18-6
Price
US $0.00/KG
Min. Order
1KG
Purity
98%min
Supply Ability
30tons/month
Release date
2023-02-02
Hebei Yanxi Chemical Co., Ltd.
Product
3-Hydroxyazetidine hydrochloride 18621-18-6
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-10-08

18621-18-6, 3-Hydroxyazetidine hydrochlorideRelated Search:

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  • C3H7ClNO
  • C3H8NOCl
  • C3H7NOHCl
  • C3H7NOClH
  • Azetidines
  • Amino Acids & Derivatives
  • Heterocyclic Building Blocks
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  • Azetidine
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