Azetidine hydrochloride
- Product Name
- Azetidine hydrochloride
- CAS No.
- 36520-39-5
- Chemical Name
- Azetidine hydrochloride
- Synonyms
- AZETIDINE HCL;azetadine hydrochloride;AZETIDINE HYDROCHLORIDE;Azetidine hydrochloride 97%;Azetidine Hydrochloride >Azetidine hydrochloride ,98%;Azetidine hydrochloride ,99%;Azacyclobutane Hydrochloride;Tetrahydro-azete Hydrochloride;TriMethyleniMine Hydrochloride
- CBNumber
- CB8387400
- Molecular Formula
- C3H8ClN
- Formula Weight
- 93.55
- MOL File
- 36520-39-5.mol
Azetidine hydrochloride Property
- Melting point:
- >300 °C(lit.)
- Flash point:
- 152 °C
- storage temp.
- Inert atmosphere,2-8°C
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
- Soluble in water (103.8°C at 760 mmHg).
- Sensitive
- Hygroscopic
- InChI
- InChI=1S/C3H7N.ClH/c1-2-4-3-1;/h4H,1-3H2;1H
- InChIKey
- HGQULGDOROIPJN-UHFFFAOYSA-N
- SMILES
- C1CNC1.Cl
- CAS DataBase Reference
- 36520-39-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 414336
- Product name
- Azetidine hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $114
- Updated
- 2025/07/31
- Product number
- 414336
- Product name
- Azetidine hydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $332
- Updated
- 2025/07/31
- Product number
- A2451
- Product name
- Azetidine Hydrochloride
- Purity
- >95.0%(N)(T)
- Packaging
- 1g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- A2451
- Product name
- Azetidine Hydrochloride
- Purity
- >95.0%(N)(T)
- Packaging
- 5g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- A813000
- Product name
- Azetidine hydrochloride
- Packaging
- 1g
- Price
- $130
- Updated
- 2021/12/16
Azetidine hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
Basic building block for synthesizing azetidines.1,2
Uses
Azetidine hydrochloride is a building block for azetidine synthesis and a pharmaceutical intermediate.
Uses
Azetidine hydrochloride is a four-membered ring nitrogen-containing heterocycle. Useful building block in the synthesis of polypeptides and other nitrogen containing compounds with potential biological properties.
General Description
Azetidine derivatives are an essential class of aza-heterocyclic compounds with various biological activities and have been widely used as building blocks in pharmacological research. Although azetidine has the simplest structure, it is only commercially available in small quantities and at a high price. In addition, this compound is hard to synthesize for several reasons, such as cyclization of the four-membered ring, stability of the ring, and low boiling point[1].
Synthesis
109-77-3
78797-58-7
Under nitrogen protection, 1,1-dicyanoethylene (500 mg, 4.2 mmol, 1.0 eq.) was dissolved in 5.0 mL of toluene in a 50 mL round bottom flask. Polymethylhydrosiloxane (PMHS, 1.0 mL, 16.8 mmol, 4.0 eq.) and tetraisopropyl titanate (Ti(Oi-Pr)4, 1.3 mL, 4.3 mmol, 1.0 eq.) were added sequentially. The reaction mixture was heated at 100 °C for 24 h. The reaction solution was observed to change from colorless to dark purple. After completion of the reaction, it was cooled to room temperature, the dark purple solution was diluted with 30 mL of toluene and hydrolyzed by adding 1 M aqueous hydrochloric acid (15 mL, 3.6 eq.) for 4 hours until the color of the solution changed from dark purple to yellow. The crude product was concentrated under reduced pressure and the resulting solid was collected by filtration and washed with 60 mL of pentane. Subsequently, the solid was dissolved in chloroform and filtered through a Celite pad. Finally, the filtrate was concentrated under reduced pressure to give the hydrochloride form of the target compound 3p.
References
[1] Jian Sun, Qi Sun, S. Gong. “A Novel Strategy for the Synthesis of Azetidine.” Advanced Materials Research 6 1 (2013): 135–138.
Azetidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Azetidine hydrochloride manufacturers
- Product
- Azetidine hydrochloride 36520-39-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10000KGS
- Release date
- 2025-02-17
- Product
- Azetidine hydrochloride 36520-39-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 99.0%min
- Supply Ability
- 200kg
- Release date
- 2023-06-12
- Product
- Azetidine hydrochloride 36520-39-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10