GCLE
- Product Name
- GCLE
- CAS No.
- 104146-10-3
- Chemical Name
- GCLE
- Synonyms
- 4-Methoxybenzyl (6R,7R)-3-(chloromethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;GCLE;Cephalosporin Impurity 4;GCLE:INTERMEDIATE FOR CEPHALOSPORIN;7-Phenglacetamido-3-chloromethyl Cephalosp;5-Thia-1-azabicyclo(4,2,0)oct-2-ene-2-carboxylic acid, 3-;4-Methoxybenzyl (6R,7R)-3-(chloromethyl)-8-oxo-7-(2-phenylac;7-Phenglacetamido-3-chloromethyl-3-cephem-4-carboxylic acid p-;(4-methoxyphenyl)methylester,(6r-trans)-7-((phenylacetyl)amino);7-Phenglacetamido-3-chloromethyl-3-cephem-4-carboxylic acid ...
- CBNumber
- CB4741459
- Molecular Formula
- C24H23ClN2O5S
- Formula Weight
- 486.97
- MOL File
- 104146-10-3.mol
GCLE Property
- Melting point:
- 153-155°C
- Boiling point:
- 756.6±60.0 °C(Predicted)
- Density
- 1.41±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
- form
- Solid
- pka
- 13.61±0.60(Predicted)
- color
- White to Off-White
- optical activity
- Consistent with structure
- InChIKey
- KFCMZNUGNLCSJQ-NFBKMPQASA-N
- SMILES
- N12[C@@]([H])([C@H](NC(CC3=CC=CC=C3)=O)C1=O)SCC(CCl)=C2C(OCC1=CC=C(OC)C=C1)=O
- CAS DataBase Reference
- 104146-10-3(CAS DataBase Reference)
Safety
- RTECS
- XI0369883
- HS Code
- 2941.90.3000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M2411
- Product name
- 4-Methoxybenzyl 3-Chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $36
- Updated
- 2025/07/31
- Product number
- M2411
- Product name
- 4-Methoxybenzyl 3-Chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate
- Purity
- >98.0%(N)
- Packaging
- 25g
- Price
- $105
- Updated
- 2025/07/31
- Product number
- M226085
- Product name
- 4-Methoxybenzyl 3-Chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate
- Packaging
- 1g
- Price
- $50
- Updated
- 2021/12/16
- Product number
- 44490
- Product name
- 4-Methoxybenzyl3-Chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate,≥98%
- Purity
- ≥98%
- Packaging
- 5G
- Price
- $36.7
- Updated
- 2021/12/16
- Product number
- 073129
- Product name
- 4-Methoxybenzyl 3-chloromethyl-7-(2-phenyl-acetamido)-3-cephem-4-carboxylate
- Purity
- 95+%
- Packaging
- 100g
- Price
- $275
- Updated
- 2021/12/16
GCLE Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
4-Methoxybenzyl 3-Chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate is a key intermediate of cephem compounds.
Uses
A key intermediate of cephem compounds.
Synthesis
131903-39-4
104146-10-3
The general procedure for the synthesis of (6R,7R)-3-(chloromethyl)-8-oxo-7-(2-phenylacetamido)-5-thiophene-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid-4-methoxybenzyl ester, using the compound (CAS:131903-39-4) as a starting material, was as follows: in 2000 mL dioxane, 120 g of sodium bicarbonate ( 1.43 mol) and 200 g of azodioxanone sulfinic acid intermediate (0.336 mmol) and stirred at 10 to 15 °C. 30 g of chlorine gas (0.422 mol) was slowly passed for about 3 h. The reaction progress was monitored by HPLC until the peak area of the feedstock dropped below 0.5%. The passage of chlorine gas was stopped, sodium bicarbonate was removed by filtration and dioxane was recovered under vacuum. 2000 mL of methanol was added to dissolve the residue and the reaction temperature was maintained at 0-5 °C. Subsequently, a 900 mL methanol solution of 18 g sodium methanolate (0.34 mol) was added and the reaction was maintained at 0~5 °C for 30 min. The pH of the reaction system was adjusted to 4~6 with 10% hydrochloric acid and stirring was continued at 0~5°C for 1 hour. After completion of the reaction, the product was collected by filtration, washed with water and methanol sequentially, and dried to give 125 g of GCLE in 76.3% yield and ≥94% purity.
References
[1] Patent: CN107033162, 2017, A. Location in patent: Paragraph 0024; 0027
GCLE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GCLE manufacturers
- Product
- GCLE 104146-10-3
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-10-31
- Product
- 4-Methoxybenzyl 3-chloromethyl-7-(2-phenylacetamido)-3-cephem-4-carboxylate 104146-10-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26
- Product
- GCLE 104146-10-3
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-08-07