1-benzhydrylazetidin-3-Ol
- Product Name
- 1-benzhydrylazetidin-3-Ol
- CAS No.
- 18621-17-5
- Chemical Name
- 1-benzhydrylazetidin-3-Ol
- Synonyms
- 1-BENZHYDRYLAZETIDIN-3-OL;1-BENZHYDRYL-3-AZETIDINOL;NSC 319045;1-BenzhydryL;Baricitinib-008;BUTTPARK 37\04-13;1-Benzydrylazetan-3-ol;-benzhydrylazetidin-3-ol;N-Benzhydryl-3-azetidinol;N-BENZHYDRYLAZETIDIN-3-OL
- CBNumber
- CB5495573
- Molecular Formula
- C16H17NO
- Formula Weight
- 239.31
- MOL File
- 18621-17-5.mol
1-benzhydrylazetidin-3-Ol Property
- Melting point:
- 106 °C
- Boiling point:
- 353.8±42.0 °C(Predicted)
- Density
- 1.189±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14.24±0.20(Predicted)
- color
- Off-White to Pale Yellow
- InChI
- InChI=1S/C16H17NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-16,18H,11-12H2
- InChIKey
- MMAJXKGUZYDTHV-UHFFFAOYSA-N
- SMILES
- N1(C(C2=CC=CC=C2)C2=CC=CC=C2)CC(O)C1
- CAS DataBase Reference
- 18621-17-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H314Causes severe skin burns and eye damage
H315Causes skin irritation
H318Causes serious eye damage
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D3907
- Product name
- 1-(Diphenylmethyl)-3-hydroxyazetidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $59
- Updated
- 2025/07/31
- Product number
- D3907
- Product name
- 1-(Diphenylmethyl)-3-hydroxyazetidine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $202
- Updated
- 2025/07/31
- Product number
- B195500
- Product name
- 1-Benzhydrylazetidin-3-ol
- Packaging
- 10g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- B1060-70
- Product name
- 1-Benzhydrylazetidin-3-ol
- Packaging
- 2g
- Price
- $425
- Updated
- 2021/12/16
- Product number
- FB18192
- Product name
- 1-Benzhydrylazetidin-3-ol
- Packaging
- 2Kg
- Price
- $450
- Updated
- 2021/12/16
1-benzhydrylazetidin-3-Ol Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
1-(Diphenylmethyl)-3-hydroxyazetidine is used to identify inhibitors of CYP 3A4.
Synthesis
63477-43-0
18621-17-5
To a solution of 1-(diphenylmethylamino)-3-chloro-2-propanol (Intermediate 32, 276 g, 1 mol) in ethanol (2 L) was slowly added N,N-diisopropylethylamine (DIPEA, 129 g, 1 mol) at 0 °C. Subsequently, the reaction mixture was heated to 90 °C and refluxed overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford the crude product 1-diphenylmethyl-3-hydroxyazetidine (179 g, 75% yield). The product can be purified by recrystallization from a solvent mixture of acetone and petroleum ether.
References
[1] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 96
[2] Medicinal Chemistry Research, 2013, vol. 22, # 12, p. 5982 - 5989
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22
[4] Synthesis (Germany), 2018, vol. 50, # 5, p. 1020 - 1026
1-benzhydrylazetidin-3-Ol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-benzhydrylazetidin-3-Ol manufacturers
- Product
- 1-Benzhydrylazetidin-3-ol 18621-17-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-11-28
- Product
- 1-(Diphenylmethyl)-3-hydroxyazetidine 18621-17-5
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-10
- Product
- 1- (Diphenylmethyl) -3-Hydroxyazetidine 18621-17-5
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20