ChemicalBook > CAS DataBase List > 1-benzhydrylazetidin-3-Ol

1-benzhydrylazetidin-3-Ol

Product Name: 1-benzhydrylazetidin-3-Ol
CAS No.: 18621-17-5
Chemical Name: 1-benzhydrylazetidin-3-Ol
Synonyms: 1-BENZHYDRYLAZETIDIN-3-OL;1-BENZHYDRYL-3-AZETIDINOL;NSC 319045;1-BenzhydryL;Baricitinib-008;BUTTPARK 37\04-13;1-Benzydrylazetan-3-ol;-benzhydrylazetidin-3-ol;N-Benzhydryl-3-azetidinol;N-BENZHYDRYLAZETIDIN-3-OL
CBNumber: CB5495573
Molecular Formula: C16H17NO
Formula Weight: 239.31
MOL File: 18621-17-5.mol

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1-benzhydrylazetidin-3-Ol Property

Melting point:: 106 °C
Boiling point:: 353.8±42.0 °C(Predicted)
Density: 1.189±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.24±0.20(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1S/C16H17NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-16,18H,11-12H2
InChIKey: MMAJXKGUZYDTHV-UHFFFAOYSA-N
SMILES: N1(C(C2=CC=CC=C2)C2=CC=CC=C2)CC(O)C1
CAS DataBase Reference: 18621-17-5(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/37/38
Safety Statements: 26-37/39
RIDADR: UN3259
Hazard Note: Irritant
HazardClass: 8
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D3907
Product name: 1-(Diphenylmethyl)-3-hydroxyazetidine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $59
Updated: 2025/07/31

TCI Chemical

Product number: D3907
Product name: 1-(Diphenylmethyl)-3-hydroxyazetidine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $202
Updated: 2025/07/31

TRC

Product number: B195500
Product name: 1-Benzhydrylazetidin-3-ol
Packaging: 10g
Price: $70
Updated: 2021/12/16

Usbiological

Product number: B1060-70
Product name: 1-Benzhydrylazetidin-3-ol
Packaging: 2g
Price: $425
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB18192
Product name: 1-Benzhydrylazetidin-3-ol
Packaging: 2Kg
Price: $450
Updated: 2021/12/16

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1-benzhydrylazetidin-3-Ol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

1-(Diphenylmethyl)-3-hydroxyazetidine is used to identify inhibitors of CYP 3A4.

Synthesis

63477-43-0

18621-17-5

To a solution of 1-(diphenylmethylamino)-3-chloro-2-propanol (Intermediate 32, 276 g, 1 mol) in ethanol (2 L) was slowly added N,N-diisopropylethylamine (DIPEA, 129 g, 1 mol) at 0 °C. Subsequently, the reaction mixture was heated to 90 °C and refluxed overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford the crude product 1-diphenylmethyl-3-hydroxyazetidine (179 g, 75% yield). The product can be purified by recrystallization from a solvent mixture of acetone and petroleum ether.

References

[1] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 96
[2] Medicinal Chemistry Research, 2013, vol. 22, # 12, p. 5982 - 5989
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22
[4] Synthesis (Germany), 2018, vol. 50, # 5, p. 1020 - 1026

1-benzhydrylazetidin-3-Ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-benzhydrylazetidin-3-Ol manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 1-Benzhydrylazetidin-3-ol 18621-17-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-28

Henan Aochuang Chemical Co.,Ltd.

Product: 1-(Diphenylmethyl)-3-hydroxyazetidine 18621-17-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Hebei Chuanghai Biotechnology Co,.LTD

Product: 1- (Diphenylmethyl) -3-Hydroxyazetidine 18621-17-5
Price: US $10.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 10 ton
Release date: 2024-08-20

18621-17-5, 1-benzhydrylazetidin-3-OlRelated Search:

Azetidine Hexamethyldisilazane 5-Methyl-1H-benzotriazole 3-Methyl butynol Heptamethyldisilazane TRIMETHYLENE OXIDE Phenethyl alcohol METHYLCYCLOHEXANOL N-Methyl-2-pyrrolidone Dehydro Azelnidipine Isopropyl 5-Hydroxy-2-methyl-4-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate 3-Amino-3-iminopropanoic acid 1-(diphenylmethyl)-3-azetidinyl ester acetate Isopropyl 2-(3-nitrobenzylidene)acetoacetate Azelnidipine Impurity 6 3-Hydroxyazetidine hydrochloride 1-Benzylazetidin-3-ol (R)-(+)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE (S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE

1-benzhydryl-3-hydroxy nitrogen heterocycle butane

1-BENZHYDRYLAZETIDINE-3-OL

NSC 319045

1-(diphenylmethyl) azetodome-3-ol

1-(Diphenylmethyl)-3-hydroxyazetidine/N-(Diphenylmethyl)azetidin-3-ol

2-(2-(3,4-difluorophenyl)hydrazono)propanoic acid

1-Diphenylmethyl-3-hydrox...

1-Benzhydrylazetidin-3-ol, 1-Benzydrylazetan-3-ol, 1-(Diphenylmethyl)azetidin-3-ol

N- two benzyl methyl n - heterocyclic butyl alcohol -3-

1-Benzhydry-3-hydroxyazetidine

1-(Diphenylmethyl)-3-azetidinol 1-Benzhydryl-3-azetidinol

1-(Diphenylmethyl)azetidin-3-ol 97%

1-Benzhydrylazetidin-3-ol, 1-Benzydrylazetan-3-ol, 1-(Diphenylmethyl)-3-hydroxyazetidine

1-Benzydrylazetan-3-ol

1-(diphenylmethyl)azetidin-3-ol

1-(Diphenylmethyl)-3-hydroxyazetinide

1-(Diphenylmethyl)-3-azetidiol

N-(Diphenylmethyl)azetidin-3-ol

1-BENZYLHYDRYL-AZETIDIN-3-OL

1-(Diphenylmethyl)-3-azetidinol

N-Benzhydryl-3-azetidinol

N- twobenzylazetidine-3- alcohol

1-(DIPHENYLMETHYL)-3-HYDROXYAZETIDINE

1-BENZHYDRYL-3-AZETIDINOL

1-BENZHYDRYL-3-HYDROXYAZETIDINE

1-BENZHYDRYLAZETIDIN-3-OL

1-BENZHYDRYL-3-HYDROXYAZETIDINE HCL

BUTTPARK 37\04-13

N-BENZHYDRYLAZETIDIN-3-OL

1-(Diphenylmethyl)-3-hydroxyazetidine&gt

N-Diphenylmethyl-3-hydroxyazetidine

1-BenzhydryL

Baricitinib-008

1-Benzhydryl-3-Azetidinol 95%

C16H17NO 1-(Diphenylmethyl)-3-hydroxyazetidine 18621-17-5

-benzhydrylazetidin-3-ol

1-BENZHYLDRYL-3-HYDROXYAZETIDINE

N-Diphenylmethyl azetidine 3-ol

1-Diphenylmethyl-3-hydroxyazetidine - [D7433]

18621-17-5

Alcohols and Derivatives

Azelnidipine

Azetidines

Amines

Heterocycles

Ring Systems

Azetidine

N-Benzhydrylazetidin

18621-17-5

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