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1-benzhydrylazetidin-3-Ol

Product Name
1-benzhydrylazetidin-3-Ol
CAS No.
18621-17-5
Chemical Name
1-benzhydrylazetidin-3-Ol
Synonyms
1-BENZHYDRYLAZETIDIN-3-OL;1-BENZHYDRYL-3-AZETIDINOL;NSC 319045;1-BenzhydryL;Baricitinib-008;BUTTPARK 37\04-13;1-Benzydrylazetan-3-ol;-benzhydrylazetidin-3-ol;N-Benzhydryl-3-azetidinol;N-BENZHYDRYLAZETIDIN-3-OL
CBNumber
CB5495573
Molecular Formula
C16H17NO
Formula Weight
239.31
MOL File
18621-17-5.mol
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1-benzhydrylazetidin-3-Ol Property

Melting point:
106 °C
Boiling point:
353.8±42.0 °C(Predicted)
Density 
1.189±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.24±0.20(Predicted)
color 
Off-White to Pale Yellow
InChI
InChI=1S/C16H17NO/c18-15-11-17(12-15)16(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15-16,18H,11-12H2
InChIKey
MMAJXKGUZYDTHV-UHFFFAOYSA-N
SMILES
N1(C(C2=CC=CC=C2)C2=CC=CC=C2)CC(O)C1
CAS DataBase Reference
18621-17-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,C
Risk Statements 
36/37/38
Safety Statements 
26-37/39
RIDADR 
UN3259
Hazard Note 
Irritant
HazardClass 
8
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H314Causes severe skin burns and eye damage

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D3907
Product name
1-(Diphenylmethyl)-3-hydroxyazetidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
D3907
Product name
1-(Diphenylmethyl)-3-hydroxyazetidine
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$202
Updated
2025/07/31
TRC
Product number
B195500
Product name
1-Benzhydrylazetidin-3-ol
Packaging
10g
Price
$70
Updated
2021/12/16
Usbiological
Product number
B1060-70
Product name
1-Benzhydrylazetidin-3-ol
Packaging
2g
Price
$425
Updated
2021/12/16
Matrix Scientific
Product number
012824
Product name
1-Benzhydrylazetan-3-ol
Purity
97%
Packaging
5g
Price
$10
Updated
2021/12/16
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1-benzhydrylazetidin-3-Ol Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

1-(Diphenylmethyl)-3-hydroxyazetidine is used to identify inhibitors of CYP 3A4.

Synthesis

63477-43-0

18621-17-5

To a solution of 1-(diphenylmethylamino)-3-chloro-2-propanol (Intermediate 32, 276 g, 1 mol) in ethanol (2 L) was slowly added N,N-diisopropylethylamine (DIPEA, 129 g, 1 mol) at 0 °C. Subsequently, the reaction mixture was heated to 90 °C and refluxed overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to afford the crude product 1-diphenylmethyl-3-hydroxyazetidine (179 g, 75% yield). The product can be purified by recrystallization from a solvent mixture of acetone and petroleum ether.

References

[1] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 96
[2] Medicinal Chemistry Research, 2013, vol. 22, # 12, p. 5982 - 5989
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22
[4] Synthesis (Germany), 2018, vol. 50, # 5, p. 1020 - 1026

1-benzhydrylazetidin-3-Ol Preparation Products And Raw materials

Raw materials

Preparation Products

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1-benzhydrylazetidin-3-Ol Suppliers

Americas 1 Austria 1 Belgium 1 Canada 2 China 370 Europe 2 France 1 Germany 2 India 22 Japan 1 The Netherlands 1 United Kingdom 11 United States 32 Global 447
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 1-benzhydrylazetidin-3-Ol manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd
Product
1-Benzhydrylazetidin-3-ol 18621-17-5
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
Customise
Release date
2025-11-28
Henan Aochuang Chemical Co.,Ltd.
Product
1-(Diphenylmethyl)-3-hydroxyazetidine 18621-17-5
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-10
Hebei Chuanghai Biotechnology Co,.LTD
Product
1- (Diphenylmethyl) -3-Hydroxyazetidine 18621-17-5
Price
US $10.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
10 ton
Release date
2024-08-20

18621-17-5, 1-benzhydrylazetidin-3-OlRelated Search:

Azetidine Hexamethyldisilazane 5-Methyl-1H-benzotriazole 3-Methyl butynol Heptamethyldisilazane TRIMETHYLENE OXIDE Phenethyl alcohol METHYLCYCLOHEXANOL N-Methyl-2-pyrrolidone Dehydro Azelnidipine Isopropyl 5-Hydroxy-2-methyl-4-(3-nitrophenyl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate 3-Amino-3-iminopropanoic acid 1-(diphenylmethyl)-3-azetidinyl ester acetate Isopropyl 2-(3-nitrobenzylidene)acetoacetate Azelnidipine Impurity 6 3-Hydroxyazetidine hydrochloride 1-Benzylazetidin-3-ol (R)-(+)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE (S)-(-)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE

  • 1-benzhydryl-3-hydroxy nitrogen heterocycle butane
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  • 1-(Diphenylmethyl)-3-hydroxyazetidine/N-(Diphenylmethyl)azetidin-3-ol
  • 2-(2-(3,4-difluorophenyl)hydrazono)propanoic acid
  • 1-Diphenylmethyl-3-hydrox...
  • 1-Benzhydrylazetidin-3-ol, 1-Benzydrylazetan-3-ol, 1-(Diphenylmethyl)azetidin-3-ol
  • N- two benzyl methyl n - heterocyclic butyl alcohol -3-
  • 1-Benzhydry-3-hydroxyazetidine
  • 1-(Diphenylmethyl)-3-azetidinol 1-Benzhydryl-3-azetidinol
  • 1-(Diphenylmethyl)azetidin-3-ol 97%
  • 1-Benzhydrylazetidin-3-ol, 1-Benzydrylazetan-3-ol, 1-(Diphenylmethyl)-3-hydroxyazetidine
  • 1-Benzydrylazetan-3-ol
  • 1-(diphenylmethyl)azetidin-3-ol
  • 1-(Diphenylmethyl)-3-hydroxyazetinide
  • 1-(Diphenylmethyl)-3-azetidiol
  • N-(Diphenylmethyl)azetidin-3-ol
  • 1-BENZYLHYDRYL-AZETIDIN-3-OL
  • 1-(Diphenylmethyl)-3-azetidinol
  • N-Benzhydryl-3-azetidinol
  • N- twobenzylazetidine-3- alcohol
  • 1-(DIPHENYLMETHYL)-3-HYDROXYAZETIDINE
  • 1-BENZHYDRYL-3-AZETIDINOL
  • 1-BENZHYDRYL-3-HYDROXYAZETIDINE
  • 1-BENZHYDRYLAZETIDIN-3-OL
  • 1-BENZHYDRYL-3-HYDROXYAZETIDINE HCL
  • BUTTPARK 37\04-13
  • N-BENZHYDRYLAZETIDIN-3-OL
  • 1-(Diphenylmethyl)-3-hydroxyazetidine&gt
  • N-Diphenylmethyl-3-hydroxyazetidine
  • 1-BenzhydryL
  • Baricitinib-008
  • 1-Benzhydryl-3-Azetidinol 95%
  • C16H17NO 1-(Diphenylmethyl)-3-hydroxyazetidine 18621-17-5
  • -benzhydrylazetidin-3-ol
  • 1-BENZHYLDRYL-3-HYDROXYAZETIDINE
  • N-Diphenylmethyl azetidine 3-ol
  • 1-Diphenylmethyl-3-hydroxyazetidine - [D7433]
  • 18621-17-5
  • Alcohols and Derivatives
  • Azelnidipine
  • Azetidines
  • Amines
  • Heterocycles
  • Ring Systems
  • Azetidine
  • N-Benzhydrylazetidin
  • 18621-17-5
  • API