7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride

Product Name: 7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride
CAS No.: 113479-65-5
Chemical Name: 7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride
Synonyms: ACLE;136657;ACLE HCL;4-methoxybenzyl (6S)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1...;7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl est;7-AMino-3-chloroMethyl-3-cepheM-4-carboxylic acid p-Methoxybenzyl ester, HCl;7-AMINO-3-CHLOROMETHYL-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER, HYDROCHLORIDE;7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester, hydrochloride ,95%;(6R,7R)-4-METHOXYBENZYL 7-AMINO-3-(CHLOROMETHYL)-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE HCL;(4-Methoxyphenyl)methyl (6R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CBNumber: CB6470403
Molecular Formula: C16H18Cl2N2O4S
Formula Weight: 405.29
MOL File: 113479-65-5.mol

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7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride Property

Melting point:: 155-157°C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Pale Yellow to Pale Beige
Stability:: Hygroscopic
InChI: InChI=1/C16H17ClN2O4S.ClH/c1-22-11-4-2-9(3-5-11)7-23-16(21)13-10(6-17)8-24-15-12(18)14(20)19(13)15;/h2-5,12,15H,6-8,18H2,1H3;1H/t12-,15-;/s3
InChIKey: LYIIGHOYDRRHAJ-JQWYMVCGNA-N
SMILES: C(C1=C(CS[C@]2([H])[C@H](N)C(=O)N12)CCl)(=O)OCC1C=CC(OC)=CC=1.Cl |&1:5,7,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A603445
Product name: 7-Amino-3chloromethyl-3-cephem-4-carboxylicAcidp-MethoxybenzylEsterHydrochloride
Packaging: 50mg
Price: $80
Updated: 2021/12/16

Matrix Scientific

Product number: 073982
Product name: 7-Amino-3-chloromethyl-3-cephem-4-carboxylic acidp-methoxybenzyl ester hydrochloride
Purity: 95+%
Packaging: 1g
Price: $59
Updated: 2021/12/16

AK Scientific

Product number: J52057
Product name: 7-Amino-3-chloromethyl-3-cephem-4-carboxylicacidp-methoxybenzylesterhydrochloride
Packaging: 1g
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17477
Product name: 7-Amino-3 chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester hydrochloride
Packaging: 250mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17477
Product name: 7-Amino-3 chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester hydrochloride
Packaging: 500mg
Price: $95
Updated: 2021/12/16

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7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Solid

Uses

Cefazolin intermediate as antibacterials.

Uses

7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride can be used as a pharmaceutical intermediate for Cefiderocol, a novel iron-carrying cephalosporin antibiotic for the treatment of complicated urinary tract infections.

Synthesis

104146-10-3

113479-65-5

Synthesis of (6R,7R)-4-methoxybenzyl (6R,7R)-4-methoxybenzyl 7-amino-3-(chloromethyl)-8-oxo-7-(2-phenylacetamido)-5-thiophene-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate as (6R,7R)-4-methoxybenzyl 7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2 -ene-2-carboxylate hydrochloride was carried out in the following general procedure: dichloromethane (3 L) and phosphorus pentachloride (374.4 g) were added to a 10 L reaction flask, and the reaction system was cooled to about 0 °C. Pyridine (200mL) was slowly added dropwise, with the rate of dropwise acceleration controlled to maintain an internal temperature of no more than 5°C. After 1 hour of reaction, the system was further cooled to -5 °C and GCLE (7-phenylacetamido-3-chloromethylbenzyl methoxyacrylate p-methoxybenzyl ester of cerebral alanine acrylate, 584.4 g) was added in batches, keeping the internal temperature between -5 and 0 °C, and the reaction was continued for 3 hours. The reaction was rapidly cooled to -30 °C, methanol (1500 mL) was slowly added dropwise and kept at -30 °C for 1 hour. The temperature was then raised to -10°C, water (1500mL) was added dropwise, and the reaction was controlled at a temperature between -10 and 0°C for 1 hour. Finally, water (1500 mL) was added and stirred for 5 minutes. The reaction mixture was poured into a beaker with a lower spout and left to stratify. The organic phase was separated and the aqueous phase was extracted with a small amount of dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate (1000 g), filtered, and the filter cake was washed with a small amount of dichloromethane. The filtrate was slowly added dropwise to isopropyl ether (12 L) and stirred overnight. On the next day, the solid was collected by filtration and washed with a small amount of isopropyl ether to give a pale yellow solid. The solid was scraped off and dried under vacuum overnight to give a final product of 456g.

References

[1] Patent: CN106317077, 2017, A. Location in patent: Paragraph 0010; 0011l 0012

7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride Suppliers

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View Lastest Price from 7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride 113479-65-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-07

Changsha YuTeng New Materials Co., Ltd.

Product: 7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride 113479-65-5
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 95%
Supply Ability: 1tons
Release date: 2025-09-29

Zibo Hangyu Biotechnology Development Co., Ltd

Product: 7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester Hydrochloride 113479-65-5
Price: US $60.00-700.00/g
Min. Order: 10g
Purity: 99%
Supply Ability: 50
Release date: 2024-07-15

113479-65-5, 7-Amino-3 chloromethyl-3-cephem-4-carboxylic Acid p-Methoxybenzyl Ester HydrochlorideRelated Search:

Oxidized methylmorpholine Cefazolin 3-AMINOAZETIDINE Azetidine hydrochloride Methyl N,N-dimethylaminoacrylate GLYCYLGLYCINE ETHYL ESTER HYDROCHLORIDE N-BETA-AMINOETHYL-GLY-OET 2 HCL 7-AMINO-3-CHLOROMETHYL-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER, HYDROCHLORIDE H-ALA-GLY-OME HCL 7-Amino-3-methyl-3-cephem-4-carboxylic acid ethyl-3-aminocrotonate 1-METHYL-AZETIDIN-3-YLAMINE DIHYDROCHLORIDE METHYL-2-N-ACETYL CROTANOATE 3-Chloro-2-methylpropene H-SAR-OBZL HCL

(6R,7R)-4-Methoxybenzyl 7-aMino-3-(chloroMethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

7-AMino-3-chloroMethyl-3-cepheM-4-carboxylic acid p-Methoxybenzyl ester, HCl

7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl est

4-methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(chloromethyl)-8-oxo-, (4-methoxyphenyl)methyl ester, hydrochloride (1:1), (6R,7R)-

(4-methoxyphenyl)methyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

7-AMINO-3-CHLOROMETHYL-3-CEPHEM-4-CARBOXYLIC ACID P-METHOXYBENZYL ESTER, HYDROCHLORIDE

ACLE HCL

(6R,7R)-7-Amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid (4-Methoxyphenyl)methyl Ester Hydrochloride

7-Amino-3-chloromethyl-3-cephem-4-carboxylic acid p-methoxybenzyl ester, hydrochloride ,95%

136657

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-amino-3-(chloromethyl)-8-oxo-, (4-methoxyphenyl)methyl ester, monohydrochloride, (6R,7R)- (9CI)

(4-methoxyphenyl)methyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-4-METHOXYBENZYL 7-AMINO-3-(CHLOROMETHYL)-8-OXO-5-THIA-1-AZABICYCLO[4.2.0]OCT-2-ENE-2-CARBOXYLATE HCL

ACLE

4-methoxybenzyl (6S)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1...

(4-Methoxyphenyl)methyl (6R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

(6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (4-methoxyphenyl)methyl ester hydrochloride (1:1)

4-methoxybenzyl (6R,7R)-7-amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride (1:1)

(6R,7R)-7-Amino-3-(chloromethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (4-methoxy-phenyl)methyl ester HCl

113479-65-5

C16H17CLN2O4SHCL

C16H18Cl2N2O4S

C16H17O4N2SClHCl

C16H17ClN2O4SClH

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