3-Hydroxyazetidine hydrochloride
- Product Name
- 3-Hydroxyazetidine hydrochloride
- CAS No.
- 18621-18-6
- Chemical Name
- 3-Hydroxyazetidine hydrochloride
- Synonyms
- AZETIDIN-3-OL HYDROCHLORIDE;3-AZETIDINOL HYDROCHLORIDE;3-HYDROXYAZETIDINE HCL;Azetidin-3-ol hydrochloride, 3-Hydroxyazetane hydrochloride;AZETAN-2-ONE;BUTTPARK 75\04-67;Azetidine-3-ol.Hcl;Baricitinib-009-HCl;3-hydroxyazatidine HCl;3-Hydroxyl-azetidine HCl
- CBNumber
- CB0455455
- Molecular Formula
- C3H8ClNO
- Formula Weight
- 109.55
- MOL File
- 18621-18-6.mol
3-Hydroxyazetidine hydrochloride Property
- Melting point:
- 85-90 °C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- White to Off-White
- Water Solubility
- Soluble in water, DMSO, methanol.
- Sensitive
- Hygroscopic
- Stability:
- Hygroscopic
- InChI
- InChI=1S/C3H7NO.ClH/c5-3-1-4-2-3;/h3-5H,1-2H2;1H
- InChIKey
- UQUPQEUNHVVNKW-UHFFFAOYSA-N
- SMILES
- C1(O)CNC1.Cl
- CAS DataBase Reference
- 18621-18-6(CAS DataBase Reference)
Safety
- Hazard Codes
- C,Xi,Xn
- Risk Statements
- 36/37/38-41-37/38-22
- Safety Statements
- 26-36/37/39
- RIDADR
- UN1759
- WGK Germany
- 3
- Hazard Note
- Harmful/Corrosive
- HazardClass
- IRRITANT
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- 680079
- Product name
- 3-Hydroxyazetidine hydrochloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $53.9
- Updated
- 2024/03/01
- Product number
- 680079
- Product name
- 3-Hydroxyazetidine hydrochloride
- Purity
- 97%
- Packaging
- 5g
- Price
- $117.6
- Updated
- 2024/03/01
- Product number
- H1264
- Product name
- 3-Hydroxyazetidine Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 1g
- Price
- $46
- Updated
- 2024/03/01
- Product number
- H1264
- Product name
- 3-Hydroxyazetidine Hydrochloride
- Purity
- >98.0%(N)
- Packaging
- 5g
- Price
- $137
- Updated
- 2024/03/01
- Product number
- H25842
- Product name
- 3-Hydroxyazetidine hydrochloride, 97%
- Packaging
- 1g
- Price
- $84.65
- Updated
- 2024/03/01
3-Hydroxyazetidine hydrochloride Chemical Properties,Usage,Production
Description
3-hydroxyazaecyclobutane hydrochloride is an azaecyclobutane compound that is an important intermediate in the synthesis of Brectinib, which is obtained through a multi-step reaction. Brectinib was approved by the European Union. The monotherapy or in combination with methotrexate for the treatment of adult patients with moderate to severe active rheumatoid arthritis with inadequate or intolerant relief from one or more antirheumatic drugs. It is also the first JAK inhibitor approved in the European Union for the treatment of rheumatoid arthritis.
Chemical Properties
white crystal
Uses
3-Hydroxyazetidine hydrochloride is an building block used in a recent synthesis of a fluoroquinolone antibiotic and a useful intermediate in the synthesis of polypeptides.
Synthesis
A solution of l-(diphenylmethyl)-3-hydroxy azetidine hydrochloride (11.8 g) in absolute ethanol (700 mL) was hydrogenated at room temperature over Pd(OH)2/C in a Parr shaker (4 atm). After 12 hr the catalyst was filtered off and the filtrate evaporated to dryness to give3-hydroxyazetidine hydrochloride (4.20 g, 94%).
3-Hydroxyazetidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
3-Hydroxyazetidine hydrochloride Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 3-Hydroxyazetidine hydrochloride manufacturers
- Product
- 3-Hydroxyazetidine hydrochloride 18621-18-6
- Price
- US $200.00-95.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20ton
- Release date
- 2024-04-22
- Product
- 3-Hydroxyazetidine hydrochloride 18621-18-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-02
- Product
- 3-Hydroxyazetidine hydrochloride 18621-18-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 20tons
- Release date
- 2023-10-08