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Mosapride citrate

Product Name
Mosapride citrate
CAS No.
112885-42-4
Chemical Name
Mosapride citrate
Synonyms
as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapride citrate - Bio-X ?
CBNumber
CB6696030
Molecular Formula
C27H33ClFN3O10
Formula Weight
614.02
MOL File
112885-42-4.mol
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Mosapride citrate Property

Melting point:
143-145°
storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO (Slightly), Ethanol (Slightly, Sonicated)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
InChIKey
HUZTYZBFZKRPFG-UHFFFAOYSA-N
SMILES
C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=C(Cl)C(N)=CC=1OCC)(=O)NCC1OCCN(CC2C=CC(F)=CC=2)C1
CAS DataBase Reference
112885-42-4(CAS DataBase Reference)
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Safety

Toxicity
LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
30048
Product name
Mosapride (citrate)
Packaging
10mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
30048
Product name
Mosapride (citrate)
Packaging
250mg
Price
$887
Updated
2024/03/01
Cayman Chemical
Product number
30048
Product name
Mosapride (citrate)
Packaging
50mg
Price
$208
Updated
2024/03/01
Cayman Chemical
Product number
30048
Product name
Mosapride (citrate)
Packaging
100mg
Price
$384
Updated
2024/03/01
Tocris
Product number
2844
Product name
Mosapridecitrate
Purity
≥99%(HPLC)
Packaging
50
Price
$459
Updated
2021/12/16
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Mosapride citrate Chemical Properties,Usage,Production

Description

Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT4 (Ki = 69.9 nM). It is selective for 5-HT4 over 5-HT1, 5-HT2, dopamine D2, and α1- and α2-adrenergic receptors but acts as a partial antagonist at 5-HT3 (Ki = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC50s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.

Uses

Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.

Uses

As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.

Biological Activity

5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.

Synthesis

112885-41-3

112885-42-4

GENERAL STEPS: To a suspension of 1.3 g (2.5 mmol) of 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide (Compound VIII) and 3 mL of water was added 12 mL of 117% aqueous hydrochloric acid. The resulting solution was stirred at 40°C for 3 hours, cooled to 10°C and 38 mL of 4M aqueous sodium hydroxide solution was added dropwise. The precipitated mosapride base (Compound IX) was filtered and washed twice with water to give 1.05 g (100%) of Compound IX.1.01 g of the above obtained Compound IX was warmed to boiling with 25 mL of 10% aqueous citric acid solution with stirring, cooled to 0°C, the precipitated product was filtered, and washed twice with water to give 1.34 g (86%) of 4-amino-5-chloro-2-ethanol oxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate. Melting point: 110-113°C.

storage

room temperature (desiccate)

References

[1] Patent: WO2003/106440, 2003, A2. Location in patent: Page 10

Mosapride citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Mosapride citrate Suppliers

Belgium 1 Brazil 1 Canada 1 CHINA 242 Europe 1 India 24 South Korea 12 United Kingdom 7 United States 26 Global 315
Jai Radhe Sales
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Clearsynth Labs
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View Lastest Price from Mosapride citrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Mosapride citrate 112885-42-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
500kg/month
Release date
2021-07-23
Henan Aochuang Chemical Co.,Ltd.
Product
Mosapride citrate 112885-42-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-19
Hebei Zhanyao Biotechnology Co. Ltd
Product
Mosapride citrate 112885-42-4
Price
US $10.00/Kg/Bag
Min. Order
1Kg/Bag
Purity
99%
Supply Ability
20 Tons
Release date
2021-11-03

112885-42-4, Mosapride citrateRelated Search:

Mosapride Mosapride Impurity 3 Mosapride Impurity 6 Mosapride Impurity 7 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide Mosapride Impurity 8 Mosapride Impurity 2 Mosapride Citric Amide Mosapride N-Oxide Des-4-fluorobenzyl Mosapride-d5 Mosapride Impurity 4 Mosapride Lactose Conjugate Mosapride Impurity 1 Morpholin-2-yl-methylamine 2-Methylmorpholine Mosapride citrate 3-Hydroxyazetidine hydrochloride (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE

  • 4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE
  • 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate
  • Gasmotin
  • enzamidecitrate
  • yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1)
  • 4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate
  • 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
  • 4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide
  • Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate
  • 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate
  • MOSAPRIDE CITRATE
  • (+-)-4-amino-5-chloro-2-ethoxy-n-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)b
  • as4370
  • benzamide,4-amino-5-chloro-2-ethoxy-n-((4-((4-fluorophenyl)methyl)-2-morpholin
  • AS-4370 citrate
  • TAK-370 citrate
  • Mosapride citrate,>99%
  • Mosapride citrate USP/EP/BP
  • Mosapride Citrate DISCONTINUED PLEASE SEE M730995
  • Mosapride Citrate (TAK-370
  • Mosapride CitrateQ: What is Mosapride Citrate Q: What is the CAS Number of Mosapride Citrate Q: What is the storage condition of Mosapride Citrate Q: What are the applications of Mosapride Citrate
  • Mosapridecitrate/TAK-370citrate/AS-4370citrate
  • Mosapride Citrate, 10 mM in DMSO
  • MOSAPRIDE CITRATE (NON-STERILE BULK FORM)
  • Mosapride citrate - Bio-X ?
  • 112885-42-4
  • C21H25ClFN3O3C6H8O7C
  • C21H25ClFN3O3C6H8O72H20
  • C27H33ClFN3O10
  • C21H25ClFN3O3C6H8O72H2O
  • C21H25ClFN3O3C6H8O7
  • C21H25ClFN3O3C6H8O7C27H33ClFN3O10
  • Inhibitors
  • APIS
  • API
  • TAK-370, AS-4370, Gasmotin
  • Gastroprokinetic Agent