Mosapride
- Product Name
- Mosapride
- CAS No.
- 112885-41-3
- Chemical Name
- Mosapride
- Synonyms
- Moza;Mosapid;TAK-370;Mosid-MT;Moxabili;MOSAPRIDE;Mosapride reference;Mosapride USP/EP/BP;((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide/mosapride;4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE
- CBNumber
- CB3273304
- Molecular Formula
- C21H25ClFN3O3
- Formula Weight
- 421.89
- MOL File
- 112885-41-3.mol
Mosapride Property
- Melting point:
- 151-153°C
- Boiling point:
- 549.2±50.0 °C(Predicted)
- Density
- 1.272±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 13.52±0.46(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 112885-41-3(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- M731000
- Product name
- Mosapride
- Packaging
- 100mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- M4676-20
- Product name
- Mosapride
- Packaging
- 10mg
- Price
- $382
- Updated
- 2021/12/16
- Product number
- 282965
- Product name
- Mosapride
- Packaging
- 50g
- Price
- $921
- Updated
- 2021/12/16
- Product number
- 074845
- Product name
- 4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide
- Purity
- 95+%
- Packaging
- 5g
- Price
- $998
- Updated
- 2021/12/16
- Product number
- 074845
- Product name
- 4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide
- Purity
- 95+%
- Packaging
- 1g
- Price
- $370
- Updated
- 2021/12/16
Mosapride Chemical Properties,Usage,Production
Description
Mosapride citrate, a new gastroprokinetic benzamide was introduced in Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use. Mosapride is synthesized by final amidation between the corresponding benzoic acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In dogs, mosapride was as potent as cisapride to stimulate antral and duodenal motility. In most of species including man, mosapride undergoes extensive cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but has potent 5-HT3 antagonist activity.
Chemical Properties
White to Off-White Crystalline Solid
Originator
Dainippon (Japan)
Uses
A selective 5-HT4 receptor agonist. Gastroprokinetic.
Uses
gastroprokinetic agent
Definition
ChEBI: Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride.
brand name
Gasmotin
Hazard
A poison by ingestion.
Safety Profile
A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.
Mosapride Preparation Products And Raw materials
Raw materials
Preparation Products
Mosapride Suppliers
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View Lastest Price from Mosapride manufacturers
- Product
- Mosapride 112885-41-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Mosapride 112885-41-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- Mosapride 112885-41-3
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-26