ChemicalBook > CAS DataBase List > Mosapride

Mosapride

Product Name
Mosapride
CAS No.
112885-41-3
Chemical Name
Mosapride
Synonyms
Moza;Mosapid;TAK-370;Mosid-MT;MOSAPRIDE;Mosapride reference;Mosapride USP/EP/BP;((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide/mosapride;4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE;4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE
CBNumber
CB3273304
Molecular Formula
C21H25ClFN3O3
Formula Weight
421.89
MOL File
112885-41-3.mol
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Mosapride Property

Melting point:
151-153°C
Boiling point:
549.2±50.0 °C(Predicted)
Density 
1.272±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.52±0.46(Predicted)
color 
White to Off-White
CAS DataBase Reference
112885-41-3(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
M731000
Product name
Mosapride
Packaging
100mg
Price
$215
Updated
2021/12/16
Usbiological
Product number
M4676-20
Product name
Mosapride
Packaging
10mg
Price
$382
Updated
2021/12/16
Usbiological
Product number
282965
Product name
Mosapride
Packaging
50g
Price
$921
Updated
2021/12/16
ApexBio Technology
Product number
B1059
Product name
Mosapride
Packaging
10mg
Price
$55
Updated
2021/12/16
AK Scientific
Product number
M687
Product name
Mosapride
Packaging
50mg
Price
$162
Updated
2021/12/16
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Mosapride Chemical Properties,Usage,Production

Description

Mosapride citrate, a new gastroprokinetic benzamide was introduced in Japan as Gasmotin for the relief of gastrointestinal symptoms in patients with chronic gastritis, gastro-oesophageal reflux, dyspepsia and post-surgery use. Mosapride is synthesized by final amidation between the corresponding benzoic acid, itself obtained in 3 steps from methyl 4-acetamido salicylate, and the appropriate 2-aminomethyl-morpholine. Mosapride is a 5-HT4 partial agonist without notable activity for D2, 5-HT1 , 5-HT2, alpha-1 and alpha-2 receptors. In dogs, mosapride was as potent as cisapride to stimulate antral and duodenal motility. In most of species including man, mosapride undergoes extensive cleavage to a N-debenzylated metabolite which retains partial 5-HT4 activity but has potent 5-HT3 antagonist activity.

Chemical Properties

White to Off-White Crystalline Solid

Originator

Dainippon (Japan)

Uses

A selective 5-HT4 receptor agonist. Gastroprokinetic.

Uses

gastroprokinetic agent

Definition

ChEBI: Mosapride is a racemate comprising equimolar amounts of (R)- and (S)-mosapride. It is a gastroprokinetic agent which acts on 5-hydroxytryptamine type 4 (5-HT4) receptors in the gastrointestinal plexus, consequently increasing the release of acetylcholine and hence enhancing gastrointestinal motility and gastric emptying. It has a role as a gastrointestinal drug and a serotonergic agonist. It contains a (R)-mosapride and a (S)-mosapride.

brand name

Gasmotin

Hazard

A poison by ingestion.

Safety Profile

A poison by ingestion. When heated to decomposition it emits toxic vapors of NOx, F-, and Cl-.

Mosapride Preparation Products And Raw materials

Raw materials

Preparation Products

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Mosapride Suppliers

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View Lastest Price from Mosapride manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Mosapride 112885-41-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mosapride 112885-41-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Zhuozhou Wenxi import and Export Co., Ltd
Product
Mosapride 112885-41-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

112885-41-3, MosaprideRelated Search:

4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE Mosapride Impurity 3 Mosapride Impurity 6 Mosapride Impurity 7 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide Mosapride Impurity 8 Mosapride Impurity 2 Mosapride Citric Amide Mosapride N-Oxide Des-4-fluorobenzyl Mosapride-d5 Mosapride Impurity 4 Mosapride Lactose Conjugate Mosapride Impurity 1 5-Amino-4-chloro-2-methylphenol 3-Hydroxyazetidine hydrochloride 2-(4-FLUOROBENZYLAMINO)ETHANOL 4-[(4-Fluorophenyl)methyl]-2-morpholinemethanamine (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE

  • 4-AMINO-5-CHLORO-2-ETHOXY-N-((4-(4-FLUOROBENZYL)-2-MORPHOLINYL)METHYL)BENZAMIDE
  • 4-AMINO-5-CHLORO-2-ETHOXY-N-[4-(4-FLUORO-BENZYL)-MORPHOLIN-2-YLMETHYL]-BENZAMIDE
  • 4-AMINO-5-CHLORO-2-ETHOXY-N-[[[4-(4-FLUOROPHENYL)METHYL]-2-MORPHOLINYL]METHYL]-BENZAMIDE
  • ((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide/mosapride
  • 4-Amino-5-Chloro-2-Ethoxy-N-((4-(4-Fluorobenzyl)-2-Morpholinyl)Methyl)Benzamide/Mosapride
  • MOSAPRIDE
  • Mosapride reference
  • Mosapride/4-Amino-5-Chloro-2-Ethoxy-N-((4-(4-Fluorobenzyl)-2-Morpholinyl)Methyl)Benzamide
  • Mosapid
  • Mosid-MT
  • Moza
  • BenzaMide,4-aMino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)Methyl]-2-Morpholinyl]Methyl]-
  • TAK-370
  • Mosapride USP/EP/BP
  • Mosapride-FreebaseQ: What is Mosapride-Freebase Q: What is the CAS Number of Mosapride-Freebase Q: What is the storage condition of Mosapride-Freebase Q: What are the applications of Mosapride-Freebase
  • 112885-41-3
  • 12885-41-3
  • 112885-41-5
  • C21H25ClFN3O3
  • API
  • TAK-370, AS-4370, Gasmotin
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