ChemicalBook > CAS DataBase List > Mosapride citrate

Mosapride citrate

Product Name: Mosapride citrate
CAS No.: 112885-42-4
Chemical Name: Mosapride citrate
Synonyms: as4370;Gasmotin;enzamidecitrate;AS-4370 citrate;TAK-370 citrate;MOSAPRIDE CITRATE;Mosapride citrate,>99%;Mosapride Citrate (TAK-370;Mosapride citrate USP/EP/BP;Mosapride citrate - Bio-X ?
CBNumber: CB6696030
Molecular Formula: C27H33ClFN3O10
Formula Weight: 614.02
MOL File: 112885-42-4.mol

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Mosapride citrate Property

Melting point:: 143-145°
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Ethanol (Slightly, Sonicated)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChIKey: HUZTYZBFZKRPFG-UHFFFAOYSA-N
SMILES: C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=C(Cl)C(N)=CC=1OCC)(=O)NCC1OCCN(CC2C=CC(F)=CC=2)C1
CAS DataBase Reference: 112885-42-4(CAS DataBase Reference)

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Safety

Toxicity: LD50 in male, female mice, rats (mg/kg): >3000, >3000, >3000, 1905 orally; >1000, 914, >1000, >1000 i.p.; all species >1000 s.c.; in male, female dogs (mg/kg): both >400 orally (Yatera)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30048
Product name: Mosapride (citrate)
Packaging: 10mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 30048
Product name: Mosapride (citrate)
Packaging: 250mg
Price: $887
Updated: 2024/03/01

Cayman Chemical

Product number: 30048
Product name: Mosapride (citrate)
Packaging: 50mg
Price: $208
Updated: 2024/03/01

Cayman Chemical

Product number: 30048
Product name: Mosapride (citrate)
Packaging: 100mg
Price: $384
Updated: 2024/03/01

Tocris

Product number: 2844
Product name: Mosapridecitrate
Purity: ≥99%(HPLC)
Packaging: 50
Price: $459
Updated: 2021/12/16

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Mosapride citrate Chemical Properties,Usage,Production

Description

Mosapride is an agonist of the serotonin (5-HT) receptor subtype 5-HT₄ (K_i = 69.9 nM). It is selective for 5-HT₄ over 5-HT₁, 5-HT₂, dopamine D₂, and α₁- and α₂-adrenergic receptors but acts as a partial antagonist at 5-HT₃ (K_i = 1,189 nM). It induces relaxation of precontracted rat esophageal thoracic muscularis mucosa preparations and enhances electrically evoked contractions in isolated guinea pig ileum (EC₅₀s = 208.4 and 73.2 nM, respectively). Mosapride (0.5 and 1 mg/kg, i.v.) increases antral and duodenal, but not ileal or colonic, motility in conscious dogs. It also increases gastric emptying in rats when administered at doses ranging from 0.03 to 30 mg/kg.

Uses

Mosapride Citrate is a selective SR-4 activator and a SR-3 inhibitor.

Uses

As a selective SR-4 activator and a SR-3 inhibitor, Mosapride(Mosapride citrate) is a gastroprokinetic agent that acts as a selective 5HT4 agonist which accelerates gastric emptying and is used for the treatment of acid reflux, irritable bowel syndrome and functional dyspepsia.

Biological Activity

5-HT 4 receptor agonist and 5-HT 3 receptor antagonist. Displays no activity at D 2 , α 1 , α 2 , 5-HT 1 and 5-HT 2 receptors. Gastroprokinetic agent; increases gastric emptying in rats and stimulates gastric motor actvity in conscious dogs.

Synthesis

112885-41-3

112885-42-4

GENERAL STEPS: To a suspension of 1.3 g (2.5 mmol) of 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide (Compound VIII) and 3 mL of water was added 12 mL of 117% aqueous hydrochloric acid. The resulting solution was stirred at 40°C for 3 hours, cooled to 10°C and 38 mL of 4M aqueous sodium hydroxide solution was added dropwise. The precipitated mosapride base (Compound IX) was filtered and washed twice with water to give 1.05 g (100%) of Compound IX.1.01 g of the above obtained Compound IX was warmed to boiling with 25 mL of 10% aqueous citric acid solution with stirring, cooled to 0°C, the precipitated product was filtered, and washed twice with water to give 1.34 g (86%) of 4-amino-5-chloro-2-ethanol oxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate. Melting point: 110-113°C.

storage

room temperature (desiccate)

References

[1] Patent: WO2003/106440, 2003, A2. Location in patent: Page 10

Mosapride citrate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mosapride citrate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Mosapride citrate 112885-42-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 500kg/month
Release date: 2021-07-23

Henan Aochuang Chemical Co.,Ltd.

Product: Mosapride citrate 112885-42-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Hebei Zhanyao Biotechnology Co. Ltd

Product: Mosapride citrate 112885-42-4
Price: US $10.00/Kg/Bag
Min. Order: 1Kg/Bag
Purity: 99%
Supply Ability: 20 Tons
Release date: 2021-11-03

112885-42-4, Mosapride citrateRelated Search:

Mosapride Mosapride Impurity 3 Mosapride Impurity 6 Mosapride Impurity 7 4-amino-5-chloro-2-ethoxy-N-((2-morpholinyl)methyl)benzamide Mosapride Impurity 8 Mosapride Impurity 2 Mosapride Citric Amide Mosapride N-Oxide Des-4-fluorobenzyl Mosapride-d5 Mosapride Impurity 4 Mosapride Lactose Conjugate Mosapride Impurity 1 Morpholin-2-yl-methylamine 2-Methylmorpholine Mosapride citrate 3-Hydroxyazetidine hydrochloride (4-BENZYL-1,4-OXAZINAN-2-YL)METHYLAMINE

4-AMINO-5-CHLORO-2-ETHOXY-N-[[4-(4-FLUOROBENZYL)-2-MORPHOLINYL]METHYL]BENZAMIDE CITRATE DIHYDRATE

4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-benzamide 2-hydroxy-1,2,3-propanetricarboxylate

Gasmotin

enzamidecitrate

yl)methyl)-,2-hydroxy-1,2,3-propanetricarboxylate(1:1)

4-Amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]benzamidecitrate

4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide

4-azanyl-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide

Benzamide, 4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]-2-morpholinyl]methyl]-, 2-hydroxy-1,2,3-propanetricarboxylate

4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate

MOSAPRIDE CITRATE

(+-)-4-amino-5-chloro-2-ethoxy-n-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)b

as4370

benzamide,4-amino-5-chloro-2-ethoxy-n-((4-((4-fluorophenyl)methyl)-2-morpholin

AS-4370 citrate

TAK-370 citrate

Mosapride citrate,>99%

Mosapride citrate USP/EP/BP

Mosapride Citrate DISCONTINUED PLEASE SEE M730995

Mosapride Citrate (TAK-370

Mosapride CitrateQ: What is Mosapride Citrate Q: What is the CAS Number of Mosapride Citrate Q: What is the storage condition of Mosapride Citrate Q: What are the applications of Mosapride Citrate

Mosapridecitrate/TAK-370citrate/AS-4370citrate

Mosapride Citrate, 10 mM in DMSO

MOSAPRIDE CITRATE (NON-STERILE BULK FORM)

Mosapride citrate - Bio-X ?

112885-42-4

C21H25ClFN3O3C6H8O7C

C21H25ClFN3O3C6H8O72H20

C27H33ClFN3O10

C21H25ClFN3O3C6H8O72H2O

C21H25ClFN3O3C6H8O7

C21H25ClFN3O3C6H8O7C27H33ClFN3O10

Inhibitors

APIS

API

TAK-370, AS-4370, Gasmotin

Gastroprokinetic Agent