Acetyl tributyl citrate

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Acetyl tributyl citrate

Product Name: Acetyl tributyl citrate
CAS No.: 77-90-7
Chemical Name: Acetyl tributyl citrate
Synonyms: ATBC;TRIBUTYL ACETYLCITRATE;Acetyltributylcitrat;TRIBUTYL O-ACETYLCITRATE;Tributyl citrate acetate;citroflexa4;Acetyl butyl citrate;tributylcitrateacetate;ACETYL TRI-N-BUTYL CITRATE;tributyl 2-acetoxypropane-1,2,3-tricarboxylate
CBNumber: CB0408022
Molecular Formula: C20H34O8
Formula Weight: 402.48
MOL File: 77-90-7.mol

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Acetyl tributyl citrate Property

Melting point:: -59 °C
Boiling point:: 327 °C
Density: 1.05 g/mL at 25 °C (lit.)
vapor pressure: 0.26 psi ( 20 °C)
refractive index: n20/D 1.443(lit.)
FEMA: 3080 | TRIBUTYL ACETYLCITRATE
Flash point:: >230 °F
storage temp.: Store below +30°C.
solubility: Not miscible with water, miscible with ethanol (96 per cent) and with methylene chloride.
color: Clear Colourless
Odor: at 100.00 %. very faint herbal wine sweet
Odor Type: herbal
Water Solubility: <0.1 g/100 mL
FreezingPoint: -80℃
JECFA Number: 630
BRN: 2303316
InChIKey: QZCLKYGREBVARF-UHFFFAOYSA-N
LogP: 5.227 (est)
CAS DataBase Reference: 77-90-7(CAS DataBase Reference)
NIST Chemistry Reference: 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, tributyl ester(77-90-7)
EPA Substance Registry System: Acetyl tributyl citrate (77-90-7)

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Safety

Safety Statements: 24/25
WGK Germany: 3
RTECS: TZ8330000
HS Code: 29181500
Hazardous Substances Data: 77-90-7(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 1009901
Product name: Acetyltributyl citrate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $450
Updated: 2022/05/15

TCI Chemical

Product number: A0822
Product name: Tributyl O-Acetylcitrate
Purity: >97.0%(GC)
Packaging: 25mL
Price: $17
Updated: 2024/03/01

TCI Chemical

Product number: A0822
Product name: Tributyl O-Acetylcitrate
Purity: >97.0%(GC)
Packaging: 500mL
Price: $54
Updated: 2024/03/01

Sigma-Aldrich

Product number: W308005
Product name: Tributyl 2-acetylcitrate
Purity: ≥98%, FG
Packaging: sample
Price: $32.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: W308005
Product name: Tributyl 2-acetylcitrate
Purity: ≥98%, FG
Packaging: 1kg
Price: $74.4
Updated: 2024/03/01

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Acetyl tributyl citrate Chemical Properties,Usage,Production

Chemical Properties

clear colorless liquid

Chemical Properties

Acetyltributyl citrate is a clear, odorless, practically colorless, oily liquid.

Chemical Properties

Tributyl acetylcitrate has a very faint, sweet, herbaceous odor. At high levels (e.g., 1000 ppm emulsion in water), it has a mild, fruity, nondescript flavor.

Chemical Properties

Acetyl tributyl citrate (ATBC) is a colorless, odorless liquid. Its water solubility is less than 0.002 g/100 mL, but it is soluble in organic solvents.

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

Labelled Tributyl O-Acetylcitrate (T772950). Topical pharmaceutical formulation anesthetic surfactant ester.

Uses

plasticizer flavoring agent

Preparation

From citric acid via the tributyl ester followed by acetylation.

Production Methods

Acetyltributyl citrate is prepared by the esterification of citric acid with butanol followed by acylation with acetic anhydride.

Definition

Aqueous-based pharmaceutical coat- ings.

General Description

Tributyl 2-acetylcitrate is a hydrophobic biodegradable plasticizer, that is usually synthesized by esterification of citric acid. Pharmaceutically, it is used as an excipient, which is generally applied as a thin film over the tablets or capsules.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Pharmaceutical Applications

Acetyltributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings, including capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release and enteric formulations.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes. ADD750

Safety

and films intended for direct food contact. It is also used in selfadhesive thin films used for topical delivery systems. It is generally regarded as a relatively nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.
LD₅₀ (cat, oral): >50 mL/kg
LD₅₀ (mouse, IP): >4 g/kg
LD₅₀ (rat, oral): >31.5 g/kg

Carcinogenicity

The chronic toxicity of ATBC was evaluated in rats fed diets containing 200, 2000, or 20,000 ppm of ATBC for 2 years. There were no treatment- related lesions in any organs examined.

storage

Acetyltributyl citrate should be stored in a well-closed container in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, acetyltributyl citrate is a stable product.

Incompatibilities

Acetyltributyl citrate is incompatible with strong alkalis and oxidizing materials.

Regulatory Status

Included in FDA Inactive Ingredients Database (oral capsules and tablets). Included in nonparenteral medicines licensed in the UK. Approved in the USA for direct food contact in food films.

Acetyl tributyl citrate Preparation Products And Raw materials

Raw materials

1-Butanol Citric acid

Preparation Products

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View Lastest Price from Acetyl tributyl citrate manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Acetyl tributyl citrate 77-90-7
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-04-28

Ouhuang Engineering Materials (Hubei) Co., Ltd

Product: Acetyl tributyl citrate 77-90-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 10000ton
Release date: 2024-04-24

airuikechemical co., ltd.

Product: Acetyl tributyl citrate 77-90-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 20 tons
Release date: 2024-04-03

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