3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one

Product Name: 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one
CAS No.: 4176-97-0
Chemical Name: 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one
Synonyms: AD 04130-4;Andrographolide Impurity 8;DEOXYANDROGRAPHOLIDE(RG) 10mg;14-Deoxyandrographolide, 10 mM in DMSO;3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl);3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one;3-[2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-hydroxymethyl-5,8aα-dimethyl-2-methylenenaphthalen-1α-yl]ethyl]furan-2(5H)-one;3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one;3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone;3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone
CBNumber: CB32225909
Molecular Formula: C20H30O4
Formula Weight: 334.45
MOL File: 4176-97-0.mol

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3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one Property

Melting point:: 176-178℃
Boiling point:: 509.5±50.0 °C(Predicted)
Density: 1.15
storage temp.: Store at -20°C
solubility: Acetonitrile: soluble
form: A solid
pka: 14.89±0.70(Predicted)
color: White to off-white
InChI: InChI=1S/C20H30O4/c1-13-4-7-16-19(2,10-8-17(22)20(16,3)12-21)15(13)6-5-14-9-11-24-18(14)23/h9,15-17,21-22H,1,4-8,10-12H2,2-3H3/t15-,16+,17-,19+,20+/m1/s1
InChIKey: GVRNTWSGBWPJGS-YSDSKTICSA-N
SMILES: O1CC=C(CC[C@H]2[C@@]3(C)[C@@]([H])([C@@](CO)(C)[C@H](O)CC3)CCC2=C)C1=O

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL84210
Product name: 14-Deoxyandrographolide
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $549
Updated: 2025/07/31

Biosynth Carbosynth

Product number: FD139289
Product name: 14-Deoxyandrographolide
Packaging: 25mg
Price: $325
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139289
Product name: 14-Deoxyandrographolide
Packaging: 2mg
Price: $50
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139289
Product name: 14-Deoxyandrographolide
Packaging: 5mg
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD139289
Product name: 14-Deoxyandrographolide
Packaging: 10mg
Price: $160
Updated: 2021/12/16

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3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one Chemical Properties,Usage,Production

Chemical Properties

White powder, soluble in methanol, ethanol, DMSO and other organic solvents, from Andrographis paniculata (Burm. f.) Nees.

Uses

14-Deoxyandrographolide is an Ayurvedic herb Kalmegh (Andrographis paniculata) that is used to fight against respiratory viral infections.

in vivo

14-Deoxyandrographolide (40 mg/kg, intraperitoneal injection, single dose) makes rat liver cells resistant to apoptosis induced by TNF-α by downregulating the formation of death-inducing signaling complex. It enhances the activity of microsomal Ca-ATPase and increases calcium ion influx into the microsomal lumen through the NO/cGMP pathway, which in turn promotes the release of TNFRSF1A^[2].

Animal Model:	Male Sprague-Dawley rats^[2]
Dosage:	40 mg/kg; single dose
Administration:	Intraperitoneal injection (i.p.)
Result:	Reduced ALT elevation caused by TNF-α/ActD, reduced the number of hepatocyte apoptosis, and reduced the amount of TNF-α retained in the liver.

IC 50

Caspase 3

3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one Suppliers

China 112 United Kingdom 1 United States 6 Global 119

Chengdu Biopurify Phytochemicals Ltd.

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View Lastest Price from 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one manufacturers

Career Henan Chemical Co

Product: 3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone 4176-97-0
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

4176-97-0, 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-oneRelated Search:

Dehydroandrographolide 14,15-beta-dihydroxyklaineanone ANDROGRAPHOLIDE, DEOXY- 25S-Inokosterone EUDESMINE 14-DEOXY-11,12-DIDEHYDROANDROGRAPHOLIDE 3'-Demethylnobiletin 25R-Inokosterone Neoandrographolide 27-DEOXYACTEIN 3,3',4',5,6,7,8-heptamethoxyflavone 13-alpha-(21)-Epoxyeurycomanone Poricoic acid A(F) Andrographolide 3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE

3-[2-[(1R,4aS,5R,6R,8aS)-Decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone

AD 04130-4

3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)-5,8aα-dimethyl-6α-hydroxydecalin-1α-yl]ethyl]-2,5-dihydrofuran-2-one

3-[2-[(1R,4aβ)-Decahydro-6α-hydroxy-5α-hydroxymethyl-5,8aα-dimethyl-2-methylenenaphthalen-1α-yl]ethyl]furan-2(5H)-one

3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone

2(5H)-Furanone,3-[2-[(1R,4aS,5R,6R,8aS)-decahydro-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-

Andrographolide Impurity 8

platelet activating factor,rat,bovine neutrophils,14 Deoxyandrographolide,Calcium Channel,inhibit,14-Deoxyandrographolide,Ca channels,uterine smooth muscle,Inhibitor,14Deoxyandrographolide,Ca2+ channels

DEOXYANDROGRAPHOLIDE(RG) 10mg

14-Deoxyandrographolide, 10 mM in DMSO

3-[2-[(1R,4aβ)-2-Methylene-5α-(hydroxymethyl)

3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one

4176-97-0