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Neoandrographolide

Product Name
Neoandrographolide
CAS No.
27215-14-1
Chemical Name
Neoandrographolide
Synonyms
NEOANDROGRAPHOLIDE;Neoandrographiside;ANDROGRAPHOLIDE, NEO-;Neoandrographolide(SH);ANDROGRAPHOLIDE, NEO(P);ANDROGRAPHOLIDE, NEO(SH);Andrographolide Impurity 7;discount Neoandrographolide;Neoandrographolide USP/EP/BP;Neoandrographolide (Neoandrographiside)
CBNumber
CB5201318
Molecular Formula
C26H40O8
Formula Weight
480.59
MOL File
27215-14-1.mol
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Neoandrographolide Property

Melting point:
167~168℃
Boiling point:
668.1±55.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
12.93±0.70(Predicted)
form 
Solid
color 
White
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
49879
Product name
Neoandrographolide
Purity
analytical standard
Packaging
5mg
Price
$532
Updated
2024/03/01
Cayman Chemical
Product number
11742
Product name
Neoandrographolide
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
11742
Product name
Neoandrographolide
Purity
≥95%
Packaging
5mg
Price
$161
Updated
2024/03/01
Cayman Chemical
Product number
11742
Product name
Neoandrographolide
Purity
≥95%
Packaging
10mg
Price
$278
Updated
2024/03/01
TRC
Product number
N389913
Product name
Neoandrographolide
Packaging
1mg
Price
$45
Updated
2021/12/16
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Neoandrographolide Chemical Properties,Usage,Production

Description

Andrographic plants are derived from the aerial parts of Andrographis paniculata (Burm.f.) Nees and known by various vernacular names such as “chunlianqiuliu,” “yijianxi,” “lanhelian,” “kudancao,” “jinxiangcao,” “jinergou,” “India grass,” and “bitter grass.” Andrographis paniculata is planted in South and Southeast Asia, India, and Australia. This herb is also cultivated in Fujian, Guangdong, Hainan, Guangxi, Yunnan, Jiangsu, and Shaanxi provinces in China. Andrographis paniculata has been used to treat colds, sore throat, mouth sores, cough, diarrhea dysentery, and so on. Andrographis paniculata contains diterpene lactone compounds, and they have anti-inflammatory and antimicrobial activities. The main active ingredients include andrographolide, neoandrographolide, deoxy andrographolide, dehydrated andrographolide, and so on. Andrographis paniculata has been included by US Pharmacopeia.

Physical properties

Appearance: Neoandrographolide is a colorless column crystal that has been isolated from the stem and leaves of Andrographis paniculata. Melting point: 167– 168?°C. Specific optical rotation: ?48°(pyridine); ?45°(c?=?1, absolute ethanol). Solubility: Soluble in methanol, ethanol, acetone, and pyridine and slightly soluble in chloroform and water but insoluble in ether and petroleum ether.

History

The chemical constituents of Andrographis paniculata are mainly lactones and flavonoids, including the lactone compounds such as andrographolide and dehydrated andrographolide. In 1952, Kleipool first reported the separation of andrographolide from Andrographis paniculata . In 1968 and 1971, W.?R. Chan et?al. identified the chemical structure and stereostructure of andrographolide. In the 1990s, a variety of diterpene lactones were isolated from the aerial part and the lotus leaf of Andrographis paniculata, such as andrographolide, neoandrographolide, dehydroandrographolide, deoxyandrographolid, deoxyandrographiside, 8-methylandrograpanin, 3-dehydrodeoxyandrographolide, andrograpanin, and 3-oxo-14-deoxy-andrographol,and also some flavonoids and sitosterol and daucosterol compounds . Until now, more than 40 diterpene lactone components and more than 70 flavonoids have been found from Andrographis paniculata. There are sterols, organic acids, diterpene alcohols, diterpene acid salts, and cycloalkene ether also found from Andrographis paniculata .
Since the 1970s, pharmacists and organic chemists have done a lot of work on the modification of andrographolide, mainly in Michael addition of α, β-unsaturated lactone double bonds and three hydroxyl groups selective esterification, oxidation and substitution reactions, redox reduction of double bonds, intramolecular cyclization, and lactone ring replacement reactions , and the resulting andrographolide derivatives or analogues can improve the antibacterial, anti-inflammatory, cardiovascular system, immunomodulation, and antitumor activities.

Uses

Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia.

Indications

Neoandrographolide is available in the Pharmacopoeia of the People’s Republic of China (1977).
Neoandrographolide and andrographolide are the main active ingredients of a variety of pharmaceutical preparations containing the Andrographis herb, such as andrographolide capsules, andrographolide tablets, Andrographis injection, potassium dehydroandrographolide succinate injection, Andrographis tablets, Xiaoyan Lidan tablets, and Fufang chuan xin lian tablets. These drugs are mainly used for treating acute bacterial dysentery, acute gastroenteritis, upper respiratory tract infection, acute tonsillitis, pharyngitis, etc. In addition, they are also used to treat malignant hydatidiform mole and choriocarcinoma.

Pharmacology

Andrographis paniculata has detoxifying abilities, reduces swelling, and relieves pain. The four major diterpene lactones in Andrographis paniculata have antipyretic and anti-inflammatory activities against 2,4-dinitrophenol or endotoxin-induced fever and egg white-induced edema or croton oil-induced inflammatory models.
Animal experiments have shown that Andrographis paniculata has inhibited and delayed the body temperature elevation of persons with infections caused by pneumococcus and hemolytic streptococcus. It also can be used for treating cough and asthma and especially for treating acute bacterial dysentery, acute gastroenteritis, upper respiratory tract infection, acute tonsillitis, pharyngitis, and so on.
The active ingredients andrographolide and neoandrographolide inhibit lipopolysaccharide-induced NO production in the mouse peritoneal macrophages . Neoandrographolide at the high concentration can inhibit the macrophage outbreak caused by LPS and the proliferation of lymphocytes and can synergistically enhance the PMA stimulating effect on the respiratory outbreak. The possible mechanism is related to its ROS scavenging activity .

Clinical Use

Neoandrographolide is one of the main active ingredients of the natural plant Andrographis paniculata. But there is no formulation of neoandrographolide. Andrographis injection has been clinically used, but it has several side effects.

Neoandrographolide Preparation Products And Raw materials

Raw materials

Preparation Products

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Neoandrographolide Suppliers

Nanjing Yuanzhi Biotechnology Co. Ltd.
Tel
15805159960
Email
1211550495@qq.com
Country
China
ProdList
1795
Advantage
58
Jiangxi Baicaoyuan Biotechnology Co. , Ltd.
Tel
0791-82165230 17707911324
Email
2279635539@qq.com
Country
China
ProdList
1387
Advantage
58
Chengdu Push Bio-Technology Co., Ltd.
Tel
18080489829
Email
3004654993@qq.com
Country
China
ProdList
9209
Advantage
58
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
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View Lastest Price from Neoandrographolide manufacturers

R&D Scientific Inc.
Product
Neoandrographolide 27215-14-1
Price
US $1600.00/g
Min. Order
1g
Purity
97
Supply Ability
500 Kg
Release date
2024-03-31
Shanghai Standard Technology Co., Ltd.
Product
Neoandrographolide 27215-14-1
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2019-11-12
Career Henan Chemical Co
Product
Neoandrographolide 27215-14-1
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
25kg
Release date
2019-07-12

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