Neoandrographolide

ChemicalBook > CAS DataBase List > Neoandrographolide

Product Name: Neoandrographolide
CAS No.: 27215-14-1
Chemical Name: Neoandrographolide
Synonyms: NEOANDROGRAPHOLIDE;Neoandrographiside;ANDROGRAPHOLIDE, NEO-;ANDROGRAPHOLIDE, NEO(P);ANDROGRAPHOLIDE, NEO(SH);Andrographolide Impurity 7;discount Neoandrographolide;Neoandrographolide USP/EP/BP;Neoandrographolide (Neoandrographiside);19-hydroxy-8(17),13-laboiadien-16,15-olide-o-βD-glucopyranoside
CBNumber: CB5201318
Molecular Formula: C26H40O8
Formula Weight: 480.59
MOL File: 27215-14-1.mol

Less

Neoandrographolide Property

Melting point:: 167～168℃
Boiling point:: 668.1±55.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.93±0.70(Predicted)
color: White

Less

Safety

WGK Germany: 3

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 49879
Product name: Neoandrographolide
Purity: analytical standard
Packaging: 5mg
Price: $532
Updated: 2024/03/01

Cayman Chemical

Product number: 11742
Product name: Neoandrographolide
Purity: ≥95%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 11742
Product name: Neoandrographolide
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 11742
Product name: Neoandrographolide
Purity: ≥95%
Packaging: 10mg
Price: $278
Updated: 2024/03/01

Usbiological

Product number: 300673
Product name: Neoandrographolide
Packaging: 20mg
Price: $405
Updated: 2021/12/16

Less

Neoandrographolide Chemical Properties,Usage,Production

Description

Andrographic plants are derived from the aerial parts of Andrographis paniculata (Burm.f.) Nees and known by various vernacular names such as “chunlianqiuliu,” “yijianxi,” “lanhelian,” “kudancao,” “jinxiangcao,” “jinergou,” “India grass,” and “bitter grass.” Andrographis paniculata is planted in South and Southeast Asia, India, and Australia. This herb is also cultivated in Fujian, Guangdong, Hainan, Guangxi, Yunnan, Jiangsu, and Shaanxi provinces in China. Andrographis paniculata has been used to treat colds, sore throat, mouth sores, cough, diarrhea dysentery, and so on. Andrographis paniculata contains diterpene lactone compounds, and they have anti-inflammatory and antimicrobial activities. The main active ingredients include andrographolide, neoandrographolide, deoxy andrographolide, dehydrated andrographolide, and so on. Andrographis paniculata has been included by US Pharmacopeia.

Physical properties

Appearance: Neoandrographolide is a colorless column crystal that has been isolated from the stem and leaves of Andrographis paniculata. Melting point: 167– 168?°C. Specific optical rotation: ?48°(pyridine); ?45°(c?=?1, absolute ethanol). Solubility: Soluble in methanol, ethanol, acetone, and pyridine and slightly soluble in chloroform and water but insoluble in ether and petroleum ether.

History

The chemical constituents of Andrographis paniculata are mainly lactones and flavonoids, including the lactone compounds such as andrographolide and dehydrated andrographolide. In 1952, Kleipool first reported the separation of andrographolide from Andrographis paniculata . In 1968 and 1971, W.?R. Chan et?al. identified the chemical structure and stereostructure of andrographolide. In the 1990s, a variety of diterpene lactones were isolated from the aerial part and the lotus leaf of Andrographis paniculata, such as andrographolide, neoandrographolide, dehydroandrographolide, deoxyandrographolid, deoxyandrographiside, 8-methylandrograpanin, 3-dehydrodeoxyandrographolide, andrograpanin, and 3-oxo-14-deoxy-andrographol,and also some flavonoids and sitosterol and daucosterol compounds . Until now, more than 40 diterpene lactone components and more than 70 flavonoids have been found from Andrographis paniculata. There are sterols, organic acids, diterpene alcohols, diterpene acid salts, and cycloalkene ether also found from Andrographis paniculata .
Since the 1970s, pharmacists and organic chemists have done a lot of work on the modification of andrographolide, mainly in Michael addition of α, β-unsaturated lactone double bonds and three hydroxyl groups selective esterification, oxidation and substitution reactions, redox reduction of double bonds, intramolecular cyclization, and lactone ring replacement reactions , and the resulting andrographolide derivatives or analogues can improve the antibacterial, anti-inflammatory, cardiovascular system, immunomodulation, and antitumor activities.

Uses

Neoandrographolide is one of the principle diterpenoids isolated from A. paniculata, a well-recognized medicinal plant in Asia.

Indications

Neoandrographolide is available in the Pharmacopoeia of the People’s Republic of China (1977).
Neoandrographolide and andrographolide are the main active ingredients of a variety of pharmaceutical preparations containing the Andrographis herb, such as andrographolide capsules, andrographolide tablets, Andrographis injection, potassium dehydroandrographolide succinate injection, Andrographis tablets, Xiaoyan Lidan tablets, and Fufang chuan xin lian tablets. These drugs are mainly used for treating acute bacterial dysentery, acute gastroenteritis, upper respiratory tract infection, acute tonsillitis, pharyngitis, etc. In addition, they are also used to treat malignant hydatidiform mole and choriocarcinoma.

Pharmacology

Andrographis paniculata has detoxifying abilities, reduces swelling, and relieves pain. The four major diterpene lactones in Andrographis paniculata have antipyretic and anti-inflammatory activities against 2,4-dinitrophenol or endotoxin-induced fever and egg white-induced edema or croton oil-induced inflammatory models.
Animal experiments have shown that Andrographis paniculata has inhibited and delayed the body temperature elevation of persons with infections caused by pneumococcus and hemolytic streptococcus. It also can be used for treating cough and asthma and especially for treating acute bacterial dysentery, acute gastroenteritis, upper respiratory tract infection, acute tonsillitis, pharyngitis, and so on.
The active ingredients andrographolide and neoandrographolide inhibit lipopolysaccharide-induced NO production in the mouse peritoneal macrophages . Neoandrographolide at the high concentration can inhibit the macrophage outbreak caused by LPS and the proliferation of lymphocytes and can synergistically enhance the PMA stimulating effect on the respiratory outbreak. The possible mechanism is related to its ROS scavenging activity .

Clinical Use

Neoandrographolide is one of the main active ingredients of the natural plant Andrographis paniculata. But there is no formulation of neoandrographolide. Andrographis injection has been clinically used, but it has several side effects.

Neoandrographolide Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Neoandrographolide Suppliers

Canada 1 China 156 Germany 1 India 4 United Kingdom 3 United States 20 Global 185

Nanjing Yuanzhi Biotechnology Co. Ltd.

Tel: 15805159960
Email: 1211550495@qq.com
Country: China
ProdList: 1793
Advantage: 58

Jiangxi Baicaoyuan Biotechnology Co. , Ltd.

Tel: 0791-82165230 17707911324
Email: 2279635539@qq.com
Country: China
ProdList: 1387
Advantage: 58

Chengdu Push Bio-Technology Co., Ltd.

Tel: 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 9209
Advantage: 58

Chengdu Nakeli Biotechnology Co., Ltd.

Tel: 028-61983833 19138982515
Fax: 3265827856
Email: 3265827856@qq.com
Country: China
ProdList: 1538
Advantage: 58

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

BEST-REAGENT

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11726
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5654
Advantage: 65

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9725
Advantage: 55

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Chengdu Climax Biotech Co., Ltd.

Tel: 028-83311324 1278112614
Fax: 028-83311324
Email: climaxbiotech@gmail.com
Country: China
ProdList: 925
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12338
Advantage: 58

Shanghai Ruji Biology Technology Co., Ltd.

Tel: +86-21-65211385-8001 36031160
Fax: +86-21-65211385-8004
Email: sales@shruji.com
Country: China
ProdList: 3224
Advantage: 55

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3989
Advantage: 66

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Chengdu Herbpurify Co.Ltd.

Tel: 18302802153 18981717076
Fax: 086-28-85377358
Email: 2355253616@qq.com
Country: China
ProdList: 1104
Advantage: 58

Shanghai BeiZhuo Biotech Co., Ltd.

Tel: 021-61119791,13386096464
Fax: 021-50190009
Email: bzswkf@foxmail.com
Country: China
ProdList: 3924
Advantage: 50

Shanghai Zhanshu Chemical Technology Co., Ltd

Tel: +86-21-58589556
Fax: +86-21-58589557
Country: China
ProdList: 413
Advantage: 55

Vientiane Tianjin Hengyuan Technology Co., Ltd.

Tel: 15722085254
Fax: 022-26358246
Email: phytochemical@126.com
Country: China
ProdList: 813
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9986
Advantage: 55

BeiJing TOP Science Bio-Technology Co., Ltd.

Tel: +86-13439059536 +86-15201677815
Country: China
ProdList: 291
Advantage: 58

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7892
Advantage: 56

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
Advantage: 58

Shanghai Aspire Biological Technology Co., Ltd.

Tel: 021-61317773
Fax: 021-61486878
Email: sales@aspirebio.com
Country: China
ProdList: 2881
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8147
Advantage: 55

Hubei kangen Pharmaceutical Chemical Co., Ltd

Tel: 15337215803 15337215803
Fax: 027-89771658
Email: 3357312443@qq.com
Country: China
ProdList: 235
Advantage: 56

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 27322
Advantage: 60

Shanghai QianYan Bio-technology Co., Ltd

Tel: 02781293128
Email: orders@biochemsafebuy.com
Country: China
ProdList: 9934
Advantage: 55

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20810
Advantage: 60

Shanghai ChengShao Biological Technology Co., Ltd.

Tel: 021-61847300 13341622919
Fax: 021-61847300
Email: shcss01@163.com
Country: China
ProdList: 4809
Advantage: 58

WG reagent

Tel: 13391486464
Fax: QQ:14748090
Email: samwjf@163.com
Country: China
ProdList: 3090
Advantage: 55

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 4009686088
Email: 3193328036@qq.com
Country: China
ProdList: 29796
Advantage: 68

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886750 13927877953
Fax: 0751-2886750
Email: 3005811397@qq.com
Country: China
ProdList: 13345
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12308
Advantage: 58

Shanghai Yihe Biological Technology Co., Ltd.

Tel: 17721395025
Fax: 021-68882955
Email: 2423903095@qq.com
Country: China
ProdList: 3154
Advantage: 58

Shanghai Uteam Biotechnology Co., Ltd.

Tel: 021-36031160 13311776681
Email: 3338195766@QQ.com
Country: China
ProdList: 5175
Advantage: 55

Shanghai Biological Technology Development Co., Ltd.

Tel: 021-69955236-807 13918189704
Fax: 021-65211385
Email: chinaruji@chinaruji.com
Country: China
ProdList: 5176
Advantage: 55

Chengdu Saiousi Pharmaceutical Co., Ltd

Tel: 028-64971018 18108168130
Fax: 86 028-64971018
Country: China
ProdList: 1781
Advantage: 55

Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-85370565-229 18080489829
Email: 3004654993@qq.com
Country: China
ProdList: 9174
Advantage: 60

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28821
Advantage: 58

Chengdu Caoyuankang Biological Technology Co., Ltd.

Tel: 028-1343889 13438890071
Fax: 028-67271232
Email: 3003796343@qq.com
Country: China
ProdList: 539
Advantage: 58

Chengdu Alfa Biotechnology Co.,Ltd.

Tel: 028-85142057, 18030712385
Fax: 028-85142057 QQ:3591697873
Email: sales@alfabiotech.com
Country: China
ProdList: 1925
Advantage: 58

Chengdu Greenpure Biopharma CO.,Ltd

Tel: 028-88203606; 18283602253
Email: jancyzheng@gcgreenpure.com
Country: China
ProdList: 1587
Advantage: 58

Shanghai Standard Technology Co.,Ltd.

Tel: 021-57127007-6622 15618937986
Fax: +86 (21) 5132-0077
Email: zhaok@nature-standard.com
Country: China
ProdList: 3928
Advantage: 58

Aikon International Limited

Tel: 025-66113011 13155353615
Fax: (7)02557626880
Email: qzhang@aikonchem.com
Country: China
ProdList: 15396
Advantage: 58

Shanghai Innovative Reseach Center Of Traditional

Tel: 86-21-50801717-301
Fax: 86-21-50800509
Email: wangjh@sirc-tcm.sh.cn
Country: China
ProdList: 2070
Advantage: 58

Linyi Azelasi Biological Co., Ltd.

Tel: 17753923223
Fax: 0539-6222546
Email: 2805221329@qq.com
Country: China
ProdList: 1474
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Shanghai Han-Xiang Chemical Co., Ltd.

Tel: 15971444841
Fax: 18327183813
Email: amber@biochempartner.com
Country: China
ProdList: 3063
Advantage: 58

Less

View Lastest Price from Neoandrographolide manufacturers

R&D Scientific Inc.

Product: Neoandrographolide 27215-14-1
Price: US $1600.00/g
Min. Order: 1g
Purity: 97
Supply Ability: 500 Kg
Release date: 2024-03-31

Shanghai Standard Technology Co., Ltd.

Product: Neoandrographolide 27215-14-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-11-12

Career Henan Chemical Co

Product: Neoandrographolide 27215-14-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 25kg
Release date: 2019-07-12

27215-14-1, NeoandrographolideRelated Search:

Dimethyl ether N,N-Dimethylformamide Andrographolide PotassiuM sodiuM Dehydroandrographolide Succinate Neohesperidin Neomangiferin Neosperidin dihydrochalcone neo-gambogic acid Neochlorogenic acid Dimethyl sulfoxide Dimethyl fumarate Dimethyl phthalate Dimethyl sulfide ETHANE Deoxyandrographoline 19-HYDROXY-8(17),13-LABDADIEN-16,15-OLIDE ANDROGRAPANIN(P) Neoandrographolide

3-[2-[(4as,5r,8as)-5,8a-dimethyl-2-methylidene-5-[[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1h-naphthalen-1-yl]ethyl]-5h-furan-2-one

ANDROGRAPHOLIDE, NEO-

NEOANDROGRAPHOLIDE

2(5H)-Furanone, 3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-

3-[2-[(1R,4aS,5R,8aS)-5-[(β-D-Glucopyranosyloxy)methyl]-1,2,3,4,4a,5,6,7,8,8a-decahydro-5,8a-dimethyl-2-methylenenaphthalene-1-yl]ethyl]-2(5H)-furanone

3-[2-[(1R,4aβ)-5α-[(β-D-Glucopyranosyloxy)methyl]decahydro-5,8aα-dimethyl-2-methylenenaphthalen-1α-yl]ethyl]furan-2(5H)-one

4-[2-[(4aS,5R,8aS)-5,8a-dimethyl-2-methylene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-methylol-tetrahydropyran-2-yl]oxymethyl]decalin-1-yl]ethyl]-2H-furan-5-one

4-[2-[(4aS,5R,8aS)-5,8a-dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one

ANDROGRAPHOLIDE, NEO(SH)

ANDROGRAPHOLIDE, NEO(P)

Neoandrographolide (Neoandrographiside)

19-hydroxy-8(17),13-laboiadien-16,15-olide-o-βD-glucopyranoside

D-Glucopyranosyloxy)methyl]decahydro-5,8a-dimethyl-2-methylene-1-naphthalenyl]ethyl]-2(5H)-furanone

ent-19-Hydroxy-8(17),13-labdadien-16,15-olide 19-O-β-D-glucopyranoside

Neoandrographiside

3-(2-((1S,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)methyl)-decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one

Neoandrographolide USP/EP/BP

Andrographolide Impurity 7

4-[2-[(1R,4aS,5R,8aS)-5,8a-dimethyl-2-methylidene-5-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethyl]-2H-furan-5-one

discount Neoandrographolide

3-(2-((1R,4aS,5R,8aS)-5,8a-Dimethyl-2-methylene-5-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)decahydronaphthalen-1-yl)ethyl)furan-2(5H)-one

27215-14-1

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract