8-BROMO-4-CHLORO-2-METHYLQUINOLINE

Product Name: 8-BROMO-4-CHLORO-2-METHYLQUINOLINE
CAS No.: 1201-07-6
Chemical Name: 8-BROMO-4-CHLORO-2-METHYLQUINOLINE
Synonyms: 8-BROMO-4-CHLOROQUINALDINE;2-Methyl-4-chloro-8-BroMoquinoline;8-BROMO-4-CHLORO-2-METHYLQUINOLINE;Quinoline, 8-bromo-4-chloro-2-methyl-
CBNumber: CB3223965
Molecular Formula: C10H7BrClN
Formula Weight: 256.53
MOL File: 1201-07-6.mol

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8-BROMO-4-CHLORO-2-METHYLQUINOLINE Property

Boiling point:: 321.9±37.0 °C(Predicted)
Density: 1.591±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder
pka: 1.71±0.50(Predicted)
color: Light brown

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Safety

Hazard Codes: T
Risk Statements: 25-41
Safety Statements: 26-39-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BBO000020
Product name: 8-Bromo-4-chloro-2-methylquinoline
Purity: Aldrich
Packaging: 1g
Price: $259
Updated: 2025/07/31

TRC

Product number: B678215
Product name: 8-Bromo-4-chloro-2-methylquinoline
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151032
Product name: 8-Bromo-4-chloro-2-methylquinoline
Packaging: 50mg
Price: $150
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB151032
Product name: 8-Bromo-4-chloro-2-methylquinoline
Packaging: 100mg
Price: $200
Updated: 2021/12/16

Apolloscientific

Product number: OR307816
Product name: 8-Bromo-4-chloro-2-methylquinoline
Packaging: 1g
Price: $264
Updated: 2021/12/16

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8-BROMO-4-CHLORO-2-METHYLQUINOLINE Chemical Properties,Usage,Production

Uses

8-Bromo-4-chloro-2-methylquinoline is a useful chemical for research.

Synthesis

1201-08-7

1201-07-6

Part A: To a reaction vial containing 4.76 g (20 mmol) of 8-bromo-2-methylquinolin-4-ol (Ref. J. Org. Chem. 1964, p. 3548) was slowly added 15 mL of phosphoryl chloride under ice bath cooling conditions. The reaction mixture was heated to 100 °C and maintained for 30 min, followed by cooling to room temperature. The unreacted phosphorus trichloride was removed by distillation under reduced pressure. An appropriate amount of ice water was added to the residue, and after adjusting the pH to neutral with ammonia, it was extracted with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate as eluent to give 5.0 g of 8-bromo-4-chloro-2-methylquinoline in 97% yield.

References

[1] Patent: US6350750, 2002, B1. Location in patent: Page column 5,6
[2] Medicinal Chemistry Research, 2012, vol. 21, # 10, p. 3073 - 3079,7

8-BROMO-4-CHLORO-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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8-BROMO-4-CHLORO-2-METHYLQUINOLINE Suppliers

China 45 Germany 2 The Netherlands 1 United Kingdom 3 United States 9 Global 60

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1201-07-6, 8-BROMO-4-CHLORO-2-METHYLQUINOLINERelated Search:

8-BROMO-4-CHLORO-2-METHYLQUINOLINE 6-BROMO-2-CHLORO-4-METHYLQUINOLINE 6-BROMO-4-CHLORO-2-METHYLQUINOLINE 8-Bromoquinoline 8-BROMO-4-CHLOROQUINOLINE 6-BROMO-2-CHLORO-3-METHYLQUINOLINE 4-BROMO-6-CHLORO-8-METHYLQUINOLINE 4-BROMO-7-CHLORO-2-METHYLQUINOLINE 4-BROMO-6-CHLORO-2-METHYLQUINOLINE 4-BROMO-5-CHLORO-8-METHYLQUINOLINE 4-BROMO-7-CHLORO-8-METHYLQUINOLINE 8-BROMO-4-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE 4-BROMO-8-CHLORO-6-METHYLQUINOLINE 4-BROMO-8-CHLORO-2-METHYLQUINOLINE 6-Bromo-7-chloro-8-methylquinoline 7-BROMO-2-CHLORO-3-METHYLQUINOLINE 7-BROMO-4-CHLORO-2-METHYLQUINOLINE ethyl 6-bromo-4-chloro-8-methylquinoline-3-carboxylate

8-BROMO-4-CHLOROQUINALDINE

8-BROMO-4-CHLORO-2-METHYLQUINOLINE

2-Methyl-4-chloro-8-BroMoquinoline

Quinoline, 8-bromo-4-chloro-2-methyl-

1201-07-6