ChemicalBook > CAS DataBase List > 8-BROMO-4-CHLORO-2-METHYLQUINOLINE
8-BROMO-4-CHLORO-2-METHYLQUINOLINE
- Product Name
- 8-BROMO-4-CHLORO-2-METHYLQUINOLINE
- CAS No.
- 1201-07-6
- Chemical Name
- 8-BROMO-4-CHLORO-2-METHYLQUINOLINE
- Synonyms
- 8-BROMO-4-CHLOROQUINALDINE;2-Methyl-4-chloro-8-BroMoquinoline;8-BROMO-4-CHLORO-2-METHYLQUINOLINE;Quinoline, 8-bromo-4-chloro-2-methyl-
- CBNumber
- CB3223965
- Molecular Formula
- C10H7BrClN
- Formula Weight
- 256.53
- MOL File
- 1201-07-6.mol
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8-BROMO-4-CHLORO-2-METHYLQUINOLINE Property
- Boiling point:
- 321.9±37.0 °C(Predicted)
- Density
- 1.591±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- powder
- pka
- 1.71±0.50(Predicted)
- color
- Light brown
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- BBO000020
- Product name
- 8-Bromo-4-chloro-2-methylquinoline
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $259
- Updated
- 2025/07/31
TRC
- Product number
- B678215
- Product name
- 8-Bromo-4-chloro-2-methylquinoline
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB151032
- Product name
- 8-Bromo-4-chloro-2-methylquinoline
- Packaging
- 50mg
- Price
- $150
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB151032
- Product name
- 8-Bromo-4-chloro-2-methylquinoline
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 3H32-D-1T
- Product name
- 8-Bromo-4-chloro-2-methylquinoline
- Packaging
- 1g
- Price
- $312
- Updated
- 2021/12/16
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8-BROMO-4-CHLORO-2-METHYLQUINOLINE Chemical Properties,Usage,Production
Uses
8-Bromo-4-chloro-2-methylquinoline is a useful chemical for research.
Synthesis
1201-08-7
1201-07-6
Part A: To a reaction vial containing 4.76 g (20 mmol) of 8-bromo-2-methylquinolin-4-ol (Ref. J. Org. Chem. 1964, p. 3548) was slowly added 15 mL of phosphoryl chloride under ice bath cooling conditions. The reaction mixture was heated to 100 °C and maintained for 30 min, followed by cooling to room temperature. The unreacted phosphorus trichloride was removed by distillation under reduced pressure. An appropriate amount of ice water was added to the residue, and after adjusting the pH to neutral with ammonia, it was extracted with dichloromethane. The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using ethyl acetate as eluent to give 5.0 g of 8-bromo-4-chloro-2-methylquinoline in 97% yield.
References
[1] Patent: US6350750, 2002, B1. Location in patent: Page column 5,6
[2] Medicinal Chemistry Research, 2012, vol. 21, # 10, p. 3073 - 3079,7
8-BROMO-4-CHLORO-2-METHYLQUINOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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1201-07-6, 8-BROMO-4-CHLORO-2-METHYLQUINOLINERelated Search:
8-BROMO-4-CHLORO-2-METHYLQUINOLINE
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