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CAFESTOL

Product Name: CAFESTOL
CAS No.: 469-83-0
Chemical Name: CAFESTOL
Synonyms: CAFESTOL;CAFESTEROL;Ccris 1518;Cafestol-RM;CAFESTOL(SH);Cafestol (>85%);(1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.0,12.0,]nonadeca-5(9),6-dien-17-ol;3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol;(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10ar,10bs)-
CBNumber: CB3228995
Molecular Formula: C20H28O3
Formula Weight: 316.43
MOL File: 469-83-0.mol

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CAFESTOL Property

Melting point:: 160-162℃ (Decomposition) (ethyl ether pentane )
alpha: D -101°
Boiling point:: 468.6±45.0 °C(Predicted)
Density: 1.23±0.1 g/cm3 (20 ºC 760 Torr)
RTECS: PB9185090
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Soluble in dichlormethane, DMSO or ethanol
pka: 14.44±0.40(Predicted)
form: White to off-white solid.
color: Off-White to Light Beige
optical activity: -9724 (CHCl3)
LogP: 4.234 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13999
Product name: Cafestol
Purity: ≥98%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 13999
Product name: Cafestol
Purity: ≥98%
Packaging: 10mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 13999
Product name: Cafestol
Purity: ≥98%
Packaging: 50mg
Price: $210
Updated: 2024/03/01

TRC

Product number: C079900
Product name: Cafestol(>85%)
Packaging: 50mg
Price: $1295
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594399
Product name: Cafestol
Packaging: 100mg
Price: $591.6
Updated: 2021/12/16

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CAFESTOL Chemical Properties,Usage,Production

Uses

Natural extract from coffee beans which induces glutathione S-transferase

Uses

Cafestol is a diterpene molecule that displays anti-carcinogenic properties in studies.

Definition

ChEBI: Cafestol is an organic heteropentacyclic compound and furan diterpenoid with formula C20H28O3 obtained from the unsaponifiable fraction of coffee oil (a lipid fraction obtained from coffee beans by organic solvent extraction). It has a role as a plant metabolite, an apoptosis inducer, a hypoglycemic agent, an angiogenesis inhibitor, an antineoplastic agent, an antioxidant and an anti-inflammatory agent. It is an organic heteropentacyclic compound, a tertiary alcohol, a diterpenoid, a member of furans and a primary alcohol.

in vivo

Cafestol (40-80 mg/kg; oral gavage ; 20 days) has antitumor effect in xenografted mouse model of colon cancer^[3].
Cafestol (0.4-1.1 mg/day; feed administration; 10 weeks) shows antidiabetic activity in KKAy mice^[4].

Animal Model:	HCT116 cells treated BALB/C null mice^[3]
Dosage:	40 and 80 mg/kg
Administration:	Oral gavage (i.g.); 20 days
Result:	Increased the body weight, tumor suppression rate and decreased the tumor weight. Did not change the colonic morphology. Increased the richness and diversity of intestinal flora in tumor-bearing mice. Stimulated autophagy in the colon tumors.

Animal Model:	Male KKAy mice^[4]
Dosage:	0.4 and 1.1 mg/day
Administration:	Feed administration; 10 weeks
Result:	Reduced fasting plasma glucose and increased insulin secretion. Reduced fasting glucagon was 20% lower and insulin sensitivity improved by 42% at dose of 1.1 mg.

IC 50

COX-2; NF-κB; ERK2

CAFESTOL Preparation Products And Raw materials

Raw materials

Preparation Products

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CAFESTOL Suppliers

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View Lastest Price from CAFESTOL manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: CAFESTOL 469-83-0
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 300KG
Release date: 2024-07-26

Career Henan Chemical Co

Product: CAFESTOL 469-83-0
Price: US $8.00/KG
Min. Order: 1KG
Purity: ＞98% HPLC
Supply Ability: 20 tons
Release date: 2020-02-17

469-83-0, CAFESTOLRelated Search:

1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE CAFESTOL CAFESTOL ACETATE 2-N-OCTYLFURAN, 98 2-N-DODECYLFURAN 16-O-METHYL-CAFESTOL CAFESTOL PALMITATE CAFESTOL(RG) CAFESTOL PALMITATE(RG) CAFESTOL ACETATE(RG) CAFESTOL STEARATE CAFESTOL OLEATE CAFESTOL EICOSANATE CAFESTOL LINOLEATE

CAFESTEROL

CAFESTOL

3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol

5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-

5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10ar,10bs)-

Ccris 1518

CAFESTOL(SH)

(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol

Cafestol (>85%)

(1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.0,12.0,]nonadeca-5(9),6-dien-17-ol

Cafestol-RM

469-83-0

Di-Terpenoids