CAFESTOL

Product Name: CAFESTOL
CAS No.: 469-83-0
Chemical Name: CAFESTOL
Synonyms: CAFESTOL;CAFESTEROL;Ccris 1518;Cafestol-RM;CAFESTOL(SH);Cafestol (>85%);(1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.0,12.0,]nonadeca-5(9),6-dien-17-ol;3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol;(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol;5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10ar,10bs)-
CBNumber: CB3228995
Molecular Formula: C20H28O3
Formula Weight: 316.43
MOL File: 469-83-0.mol

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CAFESTOL Property

Melting point:: 160-162℃ (Decomposition) (ethyl ether pentane )
alpha: D -101°
Boiling point:: 468.6±45.0 °C(Predicted)
Density: 1.23±0.1 g/cm3 (20 ºC 760 Torr)
RTECS: PB9185090
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Soluble in dichlormethane, DMSO or ethanol
pka: 14.44±0.40(Predicted)
form: White to off-white solid.
color: Off-White to Light Beige
optical activity: -9724 (CHCl3)
LogP: 4.234 (est)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13999
Product name: Cafestol
Purity: ≥98%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 13999
Product name: Cafestol
Purity: ≥98%
Packaging: 10mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 13999
Product name: Cafestol
Purity: ≥98%
Packaging: 50mg
Price: $210
Updated: 2024/03/01

TRC

Product number: C079900
Product name: Cafestol(>85%)
Packaging: 50mg
Price: $1295
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594399
Product name: Cafestol
Packaging: 100mg
Price: $591.6
Updated: 2021/12/16

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CAFESTOL Chemical Properties,Usage,Production

Uses

Natural extract from coffee beans which induces glutathione S-transferase

Uses

Cafestol is a diterpene molecule that displays anti-carcinogenic properties in studies.

Definition

ChEBI: Cafestol is an organic heteropentacyclic compound and furan diterpenoid with formula C20H28O3 obtained from the unsaponifiable fraction of coffee oil (a lipid fraction obtained from coffee beans by organic solvent extraction). It has a role as a plant metabolite, an apoptosis inducer, a hypoglycemic agent, an angiogenesis inhibitor, an antineoplastic agent, an antioxidant and an anti-inflammatory agent. It is an organic heteropentacyclic compound, a tertiary alcohol, a diterpenoid, a member of furans and a primary alcohol.

in vivo

Cafestol (40-80 mg/kg; oral gavage ; 20 days) has antitumor effect in xenografted mouse model of colon cancer^[3].
Cafestol (0.4-1.1 mg/day; feed administration; 10 weeks) shows antidiabetic activity in KKAy mice^[4].

Animal Model:	HCT116 cells treated BALB/C null mice^[3]
Dosage:	40 and 80 mg/kg
Administration:	Oral gavage (i.g.); 20 days
Result:	Increased the body weight, tumor suppression rate and decreased the tumor weight. Did not change the colonic morphology. Increased the richness and diversity of intestinal flora in tumor-bearing mice. Stimulated autophagy in the colon tumors.

Animal Model:	Male KKAy mice^[4]
Dosage:	0.4 and 1.1 mg/day
Administration:	Feed administration; 10 weeks
Result:	Reduced fasting plasma glucose and increased insulin secretion. Reduced fasting glucagon was 20% lower and insulin sensitivity improved by 42% at dose of 1.1 mg.

IC 50

COX-2; NF-κB; ERK2

CAFESTOL Preparation Products And Raw materials

Raw materials

Preparation Products

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CAFESTOL Suppliers

Canada 1 China 115 Europe 2 Germany 1 India 2 Switzerland 1 United Kingdom 6 United States 15 USA 1 Global 144

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

Shanghai Winherb Medical Technology Co., Ltd.

Tel: 021-38218169 13341702378
Fax: QQ：190129269
Email: winherb@126.com
Country: China
ProdList: 1245
Advantage: 58

Finetech Industry Limited

Tel: 027-87465837 19945049750
Fax: 027-8777-2287
Email: sales@finetechnology-ind.com
Country: China
ProdList: 9637
Advantage: 58

Shanghai Yongye Biotechnology Co., Ltd.

Tel: 86-021-61559134 15921386130
Fax: 021-55068248
Email: 3423497944@qq.com
Country: China
ProdList: 8144
Advantage: 55

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 6905
Advantage: 55

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9274
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

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View Lastest Price from CAFESTOL manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: CAFESTOL 469-83-0
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 300KG
Release date: 2024-07-26

Career Henan Chemical Co

Product: CAFESTOL 469-83-0
Price: US $8.00/KG
Min. Order: 1KG
Purity: ＞98% HPLC
Supply Ability: 20 tons
Release date: 2020-02-17

469-83-0, CAFESTOLRelated Search:

1-AZAKENPAULLONE KAHWEOL SEDANOLIDE S-[N-(3-PHENYLPROPYL)(THIOCARBAMOYL)]-L-CYSTEINE 2-THIO(3-IODOBENZYL)-5-(1-PYRIDYL)-[1,3,4]-OXADIAZOLE CAFESTOL CAFESTOL ACETATE 2-N-OCTYLFURAN, 98 2-N-DODECYLFURAN 16-O-METHYL-CAFESTOL CAFESTOL PALMITATE CAFESTOL(RG) CAFESTOL PALMITATE(RG) CAFESTOL ACETATE(RG) CAFESTOL STEARATE CAFESTOL OLEATE CAFESTOL EICOSANATE CAFESTOL LINOLEATE

CAFESTEROL

CAFESTOL

3bα,4,5,6,7,8,9,10,10aα,10b,11,12-Dodecahydro-7β-hydroxy-10bβ-methyl-5aβ,8β-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7α-methanol

5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs-(3balpha,5abeta,7beta,8beta,10aalpha,10bbeta))-

5A,8-Methano-5ah-cyclohepta(5,6)naphtho(2,1-B)furan-7-methanol, 3B,4,5,6,7,8,9,10,10A,10B,11,12-dodecahydro-7-hydroxy-10B-methyl-, (3bs,5as,7R,8R,10ar,10bs)-

Ccris 1518

CAFESTOL(SH)

(3bS,5aS,7R,8R,10aR,10bS)-3b,4,5,6,7,8,9,10,10a,10b,11,12-Dodecahydro-7-hydroxy-10b-methyl-5a,8-methano-5aH-cyclohepta[5,6]naphtho[2,1-b]furan-7-methanol

Cafestol (>85%)

(1S,4S,12S,13R,16R,17R)-17-(hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.01,13.0,12.0,]nonadeca-5(9),6-dien-17-ol

Cafestol-RM

469-83-0

Di-Terpenoids