N-(4-Bromobutyl)phthalimide

Product Name: N-(4-Bromobutyl)phthalimide
CAS No.: 5394-18-3
Chemical Name: N-(4-Bromobutyl)phthalimide
Synonyms: 2-(4-BROMOBUTYL)ISOINDOLINE-1,3-DIONE;2-(4-BROMOBUTYL)-1H-ISOINDOLE-1,3(2H)-DIONE;2-(4-broMobutyl)-2,3-dihydro-1H-isoindole-1,3-dione;SKL282;AKOS 92204;N-(4-BromobutyL;RSYY(Apremilast)-7;4-Bromobutylphthalimide;N-Bromobutylphthalimide;Intermediate Impurity 67
CBNumber: CB3233610
Molecular Formula: C12H12BrNO2
Formula Weight: 282.13
MOL File: 5394-18-3.mol

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N-(4-Bromobutyl)phthalimide Property

Melting point:: 76-80 °C (lit.)
Boiling point:: 165-170°C 1mm
Density: 1.5271 (rough estimate)
refractive index: 1.6320 (estimate)
Flash point:: 165-170°C/1mm
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: -2.15±0.20(Predicted)
form: Powder
color: White to light brown
Water Solubility: Soluble in ethanol. Insoluble in water.
BRN: 164119
InChIKey: UXFWTIGUWHJKDD-UHFFFAOYSA-N
CAS DataBase Reference: 5394-18-3(CAS DataBase Reference)
NIST Chemistry Reference: N-(4-bromobutyl)phthalimide(5394-18-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29251995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 100919
Product name: N-(4-Bromobutyl)phthalimide
Purity: 98%
Packaging: 10g
Price: $146.19
Updated: 2025/07/31

TCI Chemical

Product number: B1394
Product name: N-(4-Bromobutyl)phthalimide
Purity: >95.0%(HPLC)(T)
Packaging: 5g
Price: $52
Updated: 2025/07/31

TCI Chemical

Product number: B1394
Product name: N-(4-Bromobutyl)phthalimide
Purity: >95.0%(HPLC)(T)
Packaging: 25g
Price: $151
Updated: 2025/07/31

TRC

Product number: B682060
Product name: N-(4-Bromobutyl)phthalimide
Packaging: 10g
Price: $70
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK272310
Product name: N-(4-Bromobutyl)phthalimide
Purity: 98%
Packaging: 1g
Price: $14
Updated: 2021/12/16

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N-(4-Bromobutyl)phthalimide Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

N-(4-Bromobutyl)phthalimide is used in organic synthesis and the production of pharmaceutical. It can react with 1-phenyl-piperazine to get N-[4-(4-phenyl-piperazin-1-yl)-butyl]-phthalimide. It is a useful synthesis reagent used to synthesize B-cyclodextrin derivatives.

reaction suitability

reagent type: cross-linking reagent
reagent type: linker

Synthesis

110-52-1

136918-14-4

5394-18-3

General procedure for the synthesis of N-(4-bromobutyl)phthalimide from 1,4-dibromobutane and 3-hydroxy-1H-isoindol-1-one: phthalimide (148 mg, 1 mmol), 1,4-dibromobutane (1.080 g, 5 mmol) and potassium carbonate (276 mg, 2 mmol) were added to acetone (3 mL) and the reaction mixture was refluxed for 2 hours. After completion of the reaction, it was cooled to room temperature and the reaction mixture was purified by column chromatography using petroleum ether: acetone (40:1) as eluent to afford N-(4-bromobutyl)phthalimide (260 mg, 92% yield) as a white solid.

References

[1] Journal of Organic Chemistry, 2004, vol. 69, # 18, p. 6094 - 6099
[2] Angewandte Chemie - International Edition, 2018, vol. 57, # 6, p. 1532 - 1536
[3] Angew. Chem., 2018, vol. 130, # 6, p. 1548 - 1552,5
[4] European Journal of Medicinal Chemistry, 2018, vol. 145, p. 74 - 85
[5] Journal of the Chinese Chemical Society, 2013, vol. 60, # 12, p. 1431 - 1436

N-(4-Bromobutyl)phthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Bromobutyl)phthalimide Suppliers

Americas 1 Belgium 5 Canada 1 China 224 Europe 1 France 3 Germany 9 India 25 Israel 1 Japan 4 Slovakia 1 South Korea 1 Switzerland 2 The Netherlands 2 Ukraine 1 United Kingdom 18 United States 40 Global 339

China Langchem Inc.

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View Lastest Price from N-(4-Bromobutyl)phthalimide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: N-(4-Bromobutyl)phthalimide 5394-18-3
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-12-02

Henan Fengda Chemical Co., Ltd

Product: N-(4-Bromobutyl)phthalimide 5394-18-3
Price: US $35.00-1.10/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-19

Shijiazhuang tongyang Import and Export Co., LTD

Product: N-(4-Bromobutyl)phthalimide 5394-18-3
Price: US $15.00/Kg/Bag
Min. Order: 1g
Purity: 99
Supply Ability: 50ton
Release date: 2021-08-12

5394-18-3, N-(4-Bromobutyl)phthalimideRelated Search:

N-Hydroxyphthalimide Succinimide 4-Nitrophthalimide 4-Aminophthalimide 3-Nitrophthalimide O-Phthalimide Bismaleimide N-Methylphthalimide N-(4-BROMOPHENYL)METHANESULFONAMIDE, 97% N-(2-Hydroxyethyl)acrylamide, HEAA POLY(ISOBUTYLENE-CO-ISOPRENE), BROMINATED (R)-5-PHTHALIMIDO-2-BROMOVALERIC ACID N-(4-BROMOBUTOXY)PHTHALIMIDE Polyamideimide 2-(4-BROMOPENTYL)-1H-ISIONDOLE-1,3(2H)DIONE DIALIFOS 2-(4-BROMO-3-OXOBUTYL)-1H-ISOINDOLE-1,3(2H)-DIONE 2-(4-BROMOBUTYL)-5-NITRO-1H-ISOINDOLE-1,3(2H)-DIONE

AKOS 92204

2-(4-BROMOBUTYL)-1H-ISOINDOLE-1,3(2H)-DIONE

2-(4-BROMOBUTYL)ISOINDOLINE-1,3-DIONE

N-(4-BROMOBUTYL)PHTHALIMIDE

1H-Isoindole-1,3(2H)-dione, 2-(4-bromobutyl)-

1-Phthalimido-4-bromobutane

4-Bromobutylphthalimide

N-(omega-Bromobutyl)phthalimide

Phthalimide, N-(4-bromobutyl)-

N-(4-Bromobutyl)phthalimide, 98+%

N-(4-BromobutyL

N-methyl-4-N-[4-(N-phthalimido)buty]aminophthalimide

2-(4-Bromobutyl)isoindole-1,3-dione

2-(4-Bromobutyl)-2H-isoindole-1,3-dione

N-(4-Brompobutyl)phthalimide

N-(4-Bromobutyl)phthalimide 98%

4-phthalimido-1-bromobutane

2-(4-broMobutyl)-2,3-dihydro-1H-isoindole-1,3-dione

N-(4-BroMobutyl)phthaliMide, 98% 10GR

2-(4-Bromobut-1-yl)-1H-isoindole-1,3(2H)-dione, 2-(4-Bromobut-1-yl)isoindolin-1,3-dione

N-(4-Bromobut-1-yl)phthalimide

<i>N</i>-(4-Bromobutyl)phthalimide

SKL282

RSYY(Apremilast)-7

N-Bromobutylphthalimide

1-Phthalimido-4-bromobutane, 2-(4-Bromobutyl)-2,3-dihydro-1H-isoindole-1,3-dione, 2-(4-Bromobutyl)phthalimide, 4-Bromobutylphthalimide

Intermediate Impurity 67

5394-18-3

C12H12BrNO2

Cyclic Imides

Organic Building Blocks

N-Substituted Phthalimides

N-Substituted Maleimides, Succinimides & Phthalimides

Building Blocks

Carbonyl Compounds

Cyclic Imides

Linkers

Peptide Synthesis

N-Substituted Maleimides, Succinimides & Phthalimides

N-Substituted Phthalimides

Bifunctional CrosslinkersOrganic Building Blocks

Carbonyl Compounds