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lannaconitine

Product Name
lannaconitine
CAS No.
32854-75-4
Chemical Name
lannaconitine
Synonyms
LAPPACONITINE;Lannaconitine;Aconitum extract;(+)-Lappacontine;(+)-Lappaconitine;N-Acetylpuberanidine;(+)-Lappaconitine >90%;Giant Typhonium Rhizome;Aconitum kusnezoffii Reichb;acetyl-10-deoxysepaconitine
CBNumber
CB3235290
Molecular Formula
C32H44N2O8
Formula Weight
584.7
MOL File
32854-75-4.mol
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lannaconitine Property

Melting point:
217-218°
alpha 
D18 +27° (chloroform)
Boiling point:
641.72°C (rough estimate)
Density 
1.1897 (rough estimate)
refractive index 
1.6260 (estimate)
storage temp. 
Store at 2-8°C, protect from light
solubility 
Chloroform: 30 mg/ml
form 
A solid
pka
12.55±0.70(Predicted)
Stability:
Hygroscopic
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Safety

Toxicity
LD50 in mice (mg/kg): 6.9 i.v.; 9.1 i.p.; approx 20 orally (Dybing)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
L175850
Product name
(+)-Lappaconitine>90%
Packaging
100mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
300548
Product name
Lappaconitine
Packaging
20mg
Price
$295
Updated
2021/12/16
ApexBio Technology
Product number
N2258
Product name
Lannaconitine
Packaging
20mg
Price
$50
Updated
2021/12/16
Biorbyt Ltd
Product number
orb594064
Product name
Lappaconitine
Packaging
20mg
Price
$204
Updated
2021/12/16
ChemScene
Product number
CS-3588
Product name
Lappaconitine
Purity
98.04%
Packaging
100mg
Price
$250
Updated
2021/12/16
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lannaconitine Chemical Properties,Usage,Production

Description

A highly toxic aconitine alkaloid present in Aconitum leucostomum and A. septentrionale Koelle, lappaconitine crystallizes in hexagonal tablets for whichtwo melting points have been recorded. It has [α]D + 22.3° (C6H6) or [α]18D + 27.0° (CHC1 3). The early view that a methylimino group is present has been shown to be erroneous. No crystalline salts are known but the diacetyl derivative forms colourless crystals, m.p. l25-7°C. The base is only sparingly soluble in H20 and most organic solvents, but dissolves readily in CHC1 3.
Boiling the alkaloid with dilute H2S04 in a stream of H2 yields acetic acid and anthranoyllappaconine, C30H4207N2, which forms colourless rhombic tablets, m.p. 146-9°C;[α]25D + 22.07° (C6H6), giving a platinichloride tetrahydrate as brown needles, m.p. 300-31 O°C (dec.). When hydrolyzed with HCl, the base furnishes acetic and anthranilic acids and lappaconine, m.p. 96°C; [α]25D + 22.41°, giving a crystalline hydrochloride, m.p. 246-7°C and the aurichloride monohydrate, m.p. l26-7°C. Alkaline hydrolysis, on the other hand, furnishes lappaconine and lappaconitic acid (acetylanthranilic acid). From these observations, it is clear that only one hydroxyl group is associated with an acyl group in the molecule.
Pharmacologically, lappaconitine is toxic although its action is less pronounced than that of aconitine (q.v.). Toxic doses produce respiratory paralysis and have a direct action upon the heart often terminating in ventricular fibrillation.

Uses

(+)-Lappaconitine is a potential antitumor agent agent that induces HL-60 differentiation and apoptosis with analgesic activity as well.

References

Schultze, Ulfert., Arch. Pharrn., 260,230 (1922)
Weidemann., Chern. Zentr., 1,603 (1923)
Khaimova et al., Tetrahedron Lett., 2711 (1964)
Structure:
Tel'nov, Yunusov, Yunusov., Khirn. Prir. Soedin., 6, 583 (1970)
Pharmacology:
Rosendahl., quoted by Boehm,!. BioI. Chern., 170,203 (1947)

lannaconitine Preparation Products And Raw materials

Raw materials

Preparation Products

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lannaconitine Suppliers

China 186 Europe 2 Germany 2 India 1 United Kingdom 3 United States 21 Global 215
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View Lastest Price from lannaconitine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
lannaconitine 32854-75-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-01
Shaanxi TNJONE Pharmaceutical Co., Ltd
Product
Lappaconitine 32854-75-4
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2024-04-10
Henan Fengda Chemical Co., Ltd
Product
lannaconitine 32854-75-4
Price
US $6.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28

32854-75-4, lannaconitineRelated Search:

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  • 20-Ethyl-1α,14α,16β-trimethoxyaconitane-4,8,9-triol 4-[2-(acetylamino)benzoate]
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  • 20-Ethyl-1α,14α,16β-trimethoxyaconitane 4,8,9-triol 4-[2-(acetylamino)benzoate]
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