lannaconitine
- Product Name
- lannaconitine
- CAS No.
- 32854-75-4
- Chemical Name
- lannaconitine
- Synonyms
- LAPPACONITINE;Lannaconitine;Aconitum extract;(+)-Lappacontine;(+)-Lappaconitine;N-Acetylpuberanidine;(+)-Lappaconitine >90%;Giant Typhonium Rhizome;Aconitum kusnezoffii Reichb;acetyl-10-deoxysepaconitine
- CBNumber
- CB3235290
- Molecular Formula
- C32H44N2O8
- Formula Weight
- 584.7
- MOL File
- 32854-75-4.mol
lannaconitine Property
- Melting point:
- 217-218°
- alpha
- D18 +27° (chloroform)
- Boiling point:
- 641.72°C (rough estimate)
- Density
- 1.1897 (rough estimate)
- refractive index
- 1.6260 (estimate)
- storage temp.
- Store at 2-8°C, protect from light
- solubility
- Chloroform: 30 mg/ml
- form
- A solid
- pka
- 12.55±0.70(Predicted)
- Stability:
- Hygroscopic
Safety
- Toxicity
- LD50 in mice (mg/kg): 6.9 i.v.; 9.1 i.p.; approx 20 orally (Dybing)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 300548
- Product name
- Lappaconitine
- Packaging
- 20mg
- Price
- $295
- Updated
- 2021/12/16
- Product number
- L175850
- Product name
- (+)-Lappaconitine>90%
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- orb594064
- Product name
- Lappaconitine
- Packaging
- 20mg
- Price
- $204
- Updated
- 2021/12/16
- Product number
- CS-3588
- Product name
- Lappaconitine
- Purity
- 98.04%
- Packaging
- 100mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 41161
- Product name
- (+)-Lappaconitine
- Packaging
- 250mg
- Price
- $800
- Updated
- 2021/12/16
lannaconitine Chemical Properties,Usage,Production
Description
A highly toxic aconitine alkaloid present in Aconitum leucostomum and A.
septentrionale Koelle, lappaconitine crystallizes in hexagonal tablets for whichtwo melting points have been recorded. It has [α]D + 22.3° (C6H6) or [α]18D +
27.0° (CHC1 3). The early view that a methylimino group is present has been
shown to be erroneous. No crystalline salts are known but the diacetyl derivative
forms colourless crystals, m.p. l25-7°C. The base is only sparingly soluble in
H20 and most organic solvents, but dissolves readily in CHC1 3.
Boiling the alkaloid with dilute H2S04 in a stream of H2 yields acetic acid
and anthranoyllappaconine, C30H4207N2, which forms colourless rhombic
tablets, m.p. 146-9°C;[α]25D + 22.07° (C6H6), giving a platinichloride tetrahydrate as brown needles, m.p. 300-31 O°C (dec.). When hydrolyzed with HCl,
the base furnishes acetic and anthranilic acids and lappaconine, m.p. 96°C;
[α]25D + 22.41°, giving a crystalline hydrochloride, m.p. 246-7°C and the
aurichloride monohydrate, m.p. l26-7°C. Alkaline hydrolysis, on the other
hand, furnishes lappaconine and lappaconitic acid (acetylanthranilic acid). From
these observations, it is clear that only one hydroxyl group is associated with an
acyl group in the molecule.
Pharmacologically, lappaconitine is toxic although its action is less pronounced than that of aconitine (q.v.). Toxic doses produce respiratory paralysis
and have a direct action upon the heart often terminating in ventricular
fibrillation.
Uses
(+)-Lappaconitine is a potential antitumor agent agent that induces HL-60 differentiation and apoptosis with analgesic activity as well.
References
Schultze, Ulfert., Arch. Pharrn., 260,230 (1922)
Weidemann., Chern. Zentr., 1,603 (1923)
Khaimova et al., Tetrahedron Lett., 2711 (1964)
Structure:
Tel'nov, Yunusov, Yunusov., Khirn. Prir. Soedin., 6, 583 (1970)
Pharmacology:
Rosendahl., quoted by Boehm,!. BioI. Chern., 170,203 (1947)
lannaconitine Preparation Products And Raw materials
Raw materials
Preparation Products
lannaconitine Suppliers
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- Country
- Germany
- ProdList
- 1136
- Advantage
- 62
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- Germany
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View Lastest Price from lannaconitine manufacturers
- Product
- lannaconitine 32854-75-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-01
- Product
- Lappaconitine 32854-75-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20tons
- Release date
- 2024-04-10
- Product
- lannaconitine 32854-75-4
- Price
- US $6.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-28