tert-Butyl 2-aminobenzoate
- Product Name
- tert-Butyl 2-aminobenzoate
- CAS No.
- 64113-91-3
- Chemical Name
- tert-Butyl 2-aminobenzoate
- Synonyms
- TERT-BUTYL ANTHRANILATE;TERT-BUTYL 2-AMINOBENZOATE;N-butyl ortho aminobenzoate;tert-Butyl 2-aminobenzoate;tert-Butyl 2-aminobenzoate >=97.0%;tert-butyl 2-aminobenzoate - [B87144];H-2-Abz-OtBu(Tert-butyl 2-AMinobenzoate);Benzoic acid, 2-amino-, 1,1-dimethylethyl ester
- CBNumber
- CB2317593
- Molecular Formula
- C11H15NO2
- Formula Weight
- 193.24
- MOL File
- 64113-91-3.mol
tert-Butyl 2-aminobenzoate Property
- Melting point:
- 30°C
- Boiling point:
- 284.1±13.0 °C(Predicted)
- Density
- 1.06 g/mL at 20 °C (lit.)
- refractive index
- n20/D 1.540
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 2.17±0.10(Predicted)
- color
- Pale Brown to Light Brown
- BRN
- 2936796
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/38-43
- Safety Statements
- 26-36-36/37
- WGK Germany
- 3
- F
- 10-21
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 10720
- Product name
- tert-Butyl 2-aminobenzoate
- Purity
- ≥97.0%
- Packaging
- 2.5g
- Price
- $209
- Updated
- 2025/07/31
- Product number
- T205843
- Product name
- tert-Butyl 2-aminobenzoate
- Packaging
- 5mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- T205843
- Product name
- tert-Butyl 2-aminobenzoate
- Packaging
- 50mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CHM0124665
- Product name
- TERT-BUTYL 2-AMINOBENZOATE
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $875.49
- Updated
- 2021/12/16
- Product number
- CD12048461
- Product name
- tert-Butyl 2-aminobenzoate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
tert-Butyl 2-aminobenzoate Chemical Properties,Usage,Production
Uses
tert-Butyl 2-Aminobenzoate is a useful reagent for preparing alkylamino quinazolinones.
Synthesis Reference(s)
The Journal of Organic Chemistry, 43, p. 447, 1978 DOI: 10.1021/jo00397a015
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
55666-41-6
64113-91-3
The general procedure for the synthesis of tert-butyl 2-aminobenzoate from tert-butyl 2-nitrobenzoate was as follows: tert-butyl 2-nitrobenzoate (194.8 g, 0.873 mol) was dissolved in ethanol (2.5 L) in a 5 L Parr reactor, and Raney's nickel catalyst (72 g), which had been washed five times with ethanol, was added. The reaction system was degassed three times (evacuated and then filled with nitrogen). Subsequently, the system was pressurized with hydrogen (initial pressure 30 psi) and the hydrogen pressure was increased to 50 psi after 1.5 h. The reaction mixture was stirred overnight, during which time the system pressure was reduced to 30 psi and then pressurized again to 50 psi. Upon completion of the reaction (about one day), the mixture was filtered through diatomaceous earth, and the filtrate was concentrated by evaporation to afford the brown oily product tert-butyl 2-aminobenzoate (160.8 g, 95% yield). The product was characterized by 1H NMR (300 MHz, CDCl3): δ 7.82 (dd, 1H), 7.22 (ddd, 1H), 6.55-6.65 (m, 2H), 5.7 (br s, 1H), 1.58 (s, 9H).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 8, p. 2347 - 2350
[2] Patent: WO2004/18428, 2004, A1. Location in patent: Page 367
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 24, p. 7751 - 7767
[4] Journal of Organic Chemistry, 2013, vol. 78, # 18, p. 8966 - 8979
[5] Patent: WO2008/122667, 2008, A2. Location in patent: Page/Page column 53
tert-Butyl 2-aminobenzoate Preparation Products And Raw materials
Raw materials
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View Lastest Price from tert-Butyl 2-aminobenzoate manufacturers
- Product
- tert-Butyl 2-aminobenzoate 64113-91-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-11-28