4-Maleimidobenzoic acid

Product Name: 4-Maleimidobenzoic acid
CAS No.: 17057-04-4
Chemical Name: 4-Maleimidobenzoic acid
Synonyms: INCA-12;AKOS B006486;AKOS MSC-0031;ART-CHEM-BB B006486;4-MALEIMIDOBENZOIC ACID;4-(N-MaleiMido)benzoic acid;N-(4-Benzoic acid)maleimide;N-(4-CARBOXYPHENYL)MALEIMIDE;4-(2,5-Dioxo-1-pyrrolyl)benzoic acid;4-(2,5-Dioxo-1H-pyrrole-1-yl)benzoic acid
CBNumber: CB3241417
Molecular Formula: C11H7NO4
Formula Weight: 217.18
MOL File: 17057-04-4.mol

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4-Maleimidobenzoic acid Property

Melting point:: 225-228 °C
Boiling point:: 447.1±28.0 °C(Predicted)
Density: 1.521±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: powder to crystal
pka: 3.93±0.10(Predicted)
color: White to Light yellow
InChI: InChI=1S/C11H7NO4/c13-9-5-6-10(14)12(9)8-3-1-7(2-4-8)11(15)16/h1-6H,(H,15,16)
InChIKey: LKUOJDGRNKVVFF-UHFFFAOYSA-N
SMILES: C(O)(=O)C1=CC=C(N2C(=O)C=CC2=O)C=C1
CAS DataBase Reference: 17057-04-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M3257
Product name: 4-Maleimidobenzoic Acid
Packaging: 1G
Price: $84
Updated: 2025/07/31

TCI Chemical

Product number: M3257
Product name: 4-Maleimidobenzoic Acid
Packaging: 5G
Price: $284
Updated: 2025/07/31

TRC

Product number: B415405
Product name: 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoicAcid
Packaging: 50mg
Price: $45
Updated: 2021/12/16

AK Scientific

Product number: 5496AD
Product name: 4-Maleimidobenzoic Acid
Packaging: 250mg
Price: $25
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD116589
Product name: 4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid
Packaging: 5G
Price: $75
Updated: 2021/12/16

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4-Maleimidobenzoic acid Chemical Properties,Usage,Production

Uses

4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers[1].

Synthesis

108-31-6

150-13-0

17057-04-4

(1) Assemble a mechanical stirrer, thermometer, and constant pressure dropping funnel in a 500mL three-necked flask. 35g of maleic anhydride (0.357 mol) and 100mL of acetone were added to the flask and stirred at 20°C until completely dissolved. Meanwhile, a clear solution was prepared by dissolving 49 g of p-aminobenzoic acid (0.357 mol) in 250 mL of acetone. Subsequently, the acetone solution of p-aminobenzoic acid was slowly added dropwise through a constant pressure dropping funnel into a three-necked flask. After the dropwise addition, the reaction was continued with stirring for 1 hour. After completion of the reaction, filtration was carried out (recovery of solvent), and the solid product was washed with an appropriate amount of solvent, followed by recrystallization and drying to give 77.28 g of yellow crystalline N-(4-carboxyphenyl)maleimidic acid in 92% yield and 99.3% purity (HPLC analysis).

References

[1] Lau A, et, al. Conjugation of doxorubicin to monoclonal anti-carcinoembryonic antigen antibody via novel thiol-directed cross-linking reagents. Bioorg Med Chem. 1995 Oct;3(10):1299-304. DOI:10.1016/0968-0896(95)00125-z

4-Maleimidobenzoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Maleimidobenzoic acid Suppliers

Americas 1 China 95 Europe 1 France 1 Germany 4 India 2 Japan 1 Russia 3 Switzerland 1 Ukraine 2 United Kingdom 7 United States 18 Global 136

Suzhou Highfine Biotech Co., Ltd

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Adamas Reagent, Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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View Lastest Price from 4-Maleimidobenzoic acid manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 4-Maleimidobenzoic acid 17057-04-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-09-20

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 4-Maleimidobenzoic acid 17057-04-4
Price: US $3.00-9.00/KG
Min. Order: 0.1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2025-06-21

Career Henan Chemical Co

Product: 4-Maleimidobenzoic acid 17057-04-4
Price: US $10.00-100.00/KG
Min. Order: 1KG
Purity: Min98% HPLC
Supply Ability: g/kg/ton
Release date: 2020-03-06

17057-04-4, 4-Maleimidobenzoic acidRelated Search:

Folic acid Succinimide Bismaleimide EPA Maleimide O-Phthalimide Ascoric Acid DIALIFOS 3-Maleimidobenzoic acid N-hydroxysuccinimide ester 3-N-MALEIMIDOBENZOIC ACID,M-N-MALEIMIDOBENZOIC ACID N-(4-CARBOXY-3-HYDROXYPHENYL)MALEIMIDE TETRAMETHYLRHODAMINE-5-MALEIMIDE ETHYL 4-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)BENZOATE ASISCHEM C66320 4-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-BENZOIC ACID METHYL ESTER 3-MALEIMIDOBENZOIC ACID HYDRAZIDE HYDROCHLORIDE 3-MALEIMIDOBENZOIC ACID CHLORIDE 4-N-Maleimidobenzoic acid-NHS

4-(2,5-Dihydro-2,5-dioxo-1H-pyrrole-1-yl)benzoic acid

4-(2,5-Dioxo-1H-pyrrole-1-yl)benzoic acid

4-(2,5-Dioxo-1-pyrrolyl)benzoic acid

4-(2,5-Dioxo-2,5-dihydro-1H-pyrrole-1-yl)benzoic acid

INCA-12

4-(N-MaleiMido)benzoic acid

ART-CHEM-BB B006486

AKOS B006486

AKOS MSC-0031

4-MALEIMIDOBENZOIC ACID

4-(2,5-DIHYDRO-2,5-DIOXO-1HPYRROL-1YL)-BENZOIC ACID

4-(2,5-DIOXO-2,5-DIHYDRO-1H-PYRROL-1-YL)BENZOIC ACID

4-(2,5-DIOXO-2,5-DIHYDRO-PYRROL-1-YL)-BENZOIC ACID

N-(4-CARBOXYPHENYL)MALEIMIDE

N-(4-Benzoic acid)maleimide

Benzoic acid, 4-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-

4-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoicaci

4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoic acid(p-CPMI)

4-(2,5-Dioxo-2,5-dihydropyrrol-1-yl)benzoic acid, CAS 17057-04-4

17057-04-4

C11H6NO4

Miscellaneous

Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts