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Cloquintocet-mexyl

Product Name
Cloquintocet-mexyl
CAS No.
99607-70-2
Chemical Name
Cloquintocet-mexyl
Synonyms
Cloquintocet-1;oquintocet-MexyL;cloquitocet_mexyl;CLOQUINTOCET-MEXYL;Cloquintocet-methyl;Adagrasib Impurity 59;Cloquintocet-mexyl >Cloquintocet-mexyl Standard;Cloquintocet-mexyl in Acetone;Cloquintocet-mexyl in Methanol
CBNumber
CB3243431
Molecular Formula
C18H22ClNO3
Formula Weight
335.83
MOL File
99607-70-2.mol
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Cloquintocet-mexyl Property

Melting point:
69°
Boiling point:
448.4±30.0 °C(Predicted)
Density 
1.163±0.06 g/cm3(Predicted)
vapor pressure 
0-54.4Pa at 25-185.9℃
storage temp. 
Sealed in dry,2-8°C
solubility 
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
form 
Solid
pka
1.94±0.29(Predicted)
color 
White to Off-White
Merck 
14,2401
Stability:
Stable. Incompatible with strong oxidizing agents.
LogP
5.2-5.24 at 25℃ and pH5-9.1
Surface tension
56.8-57.2mN/m at 590μg/L and 20℃
Dissociation constant
3.55 at 20℃
CAS DataBase Reference
99607-70-2(CAS DataBase Reference)
EPA Substance Registry System
Cloquintocet-mexyl (99607-70-2)
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Safety

Hazard Codes 
Xi
Risk Statements 
43
Safety Statements 
36/37
RIDADR 
UN 3077
WGK Germany 
2
RTECS 
AG1265000
HS Code 
2933.49.3000
Toxicity
LD50 in rats (mg/kg): >2000 orally; >2000 dermally; LC50 (4 hr) in rats: >935 mg/m3 by inhalation (Amrein)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
31678
Product name
Cloquintocet-mexyl
Purity
PESTANAL
Packaging
250mg
Price
$91.1
Updated
2024/03/01
TCI Chemical
Product number
C2682
Product name
Cloquintocet-mexyl
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$48
Updated
2024/03/01
TRC
Product number
C583525
Product name
Cloquintocet-mexyl
Packaging
2.5g
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
171095
Product name
1-Methylhexyl 2-[(5-chloro-8-quinolinyl)oxy]acetate
Packaging
1g
Price
$148
Updated
2021/12/16
Chem-Impex
Product number
39361
Product name
Cloquintocet-mexyl,≥98%(Assaybytitration,HPLC)
Purity
≥98%(Assaybytitration,HPLC)
Packaging
1G
Price
$154.92
Updated
2021/12/16
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Cloquintocet-mexyl Chemical Properties,Usage,Production

Description

Cloquintocet-mexyl is a colourless crystalline herbicide safener. It is categorized as Class III toxin.

Chemical Properties

beige solid

Uses

Cloquintocet-mexyl is used as a herbicide.

Uses

Cloquintocet-mexyl is a herbicide. It is used to control coarse annual grass of the family poaceae (gramineae). lt was developed by the swiss ciba geigy in the 1980s and the patent has expired.

Definition

ChEBI: Heptan-2-yl [(5-chloroquinolin-8-yl)oxy]acetate is a member of the class of quinolines that is quinoline which is substituted by a chloro group at position 5 and by a 2-[(heptan-2-yl)oxy]-2-oxoethoxy group at position 8. It is an aromatic ether, an organochlorine compound, a member of quinolines and a carboxylic ester.

Agricultural Uses

Cloquintocet-mexyl is a safener that can be used in conjunction with various herbicides to reduce phytotoxicity to crops. Though effective as a safener, the manufacture, storage, and use of cloquintocet-mexyl containing products can present challenges owing to its sensitivity to water and its low melting temperature (i.e., 61-69° C. for technical material). When products containing cloquintocet-mexyl are prepared, stored, or used in the presence of water, cloquin tocet-mexyl can undergo hydrolysis to form cloquintocet acid, and/or form a needle-shaped, crystalline hydrate that can, lead to clogged spray nozzles during spray applications and/or possibly increased levels of crop phytotoxicity.

Carcinogenicity

In accordance with the EPA Proposed EPA Weight-of-the-Evidence Categories, August 1999, the HIARC classified cloquintocet-mexyl as "not likely to be a human carcinogen." Carcinogenicity studies in rats and mice did not show increased incidence of spontaneous tumor formation. With negative mutagenic test battery, it is suggested that cloquintocet-mexyl (CGA 185072) is not likely to be a human carcinogen.

Metabolism

Metabolism studies in rats indicated that approximately 40% of the administered dose of cloquintocet-mexyl was absorbed through the gastrointestinal tract and subsequently excreted via the urine. Fecal excretion accounted for approximately 60% of the administered dose. The chemical was rapidly eliminated (more than 80% of the administered dose) via feces and urine within 48 hours post-dosing. Sex, dosing regime, and dose levels had little effect on the excretion pattern. Excretion patterns were similar between the biliary cannulated and non-cannulated animals indicating that there was no enterohepatic circulation of the chemical. Three days after administration, tissue radioactivity accounted for less than 0.3% of the administered dose (or was non-detectable) and was not detectable in the expired air. At day three post-dosing, most tissue residues of radioactivity were below the limit of detection. The major metabolic pathway of cloquintocet-mexyl was ester hydrolysis to yield 5-chloro-8-quinolinoxy acetic acid, the major metabolite in the fecal and urinary pools.

Toxicity evaluation

Cloquintocet-mexyl has a low order of acute oral, dermal, and inhalation toxicity. It is slightly irritating to the eyes and non-irritating to the skin. Cloquintocet-mexyl is a skin sensitizer. The chemical is not genotoxic and is not a reproductive and developmental toxicant. There is no evidence of neurotoxicity in the available studies. Cloquintocet-mexyl is classified as “not likely to be a human carcinogen.” The main metabolite for cloquintocet-mexyl is 5-chloro-8-quin-linoxyacetic acid, and testing on the metabolite is part of the toxicology database for cloquintocet-mexyl.

Cloquintocet-mexyl Preparation Products And Raw materials

Raw materials

Preparation Products

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Cloquintocet-mexyl Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Harvest Chemical Industrial Co., Ltd.
Tel
21-31038972 15721252604
Fax
+86-21-51385350
Email
ammyzuo@harvest-chem.com
Country
China
ProdList
2540
Advantage
64
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8844
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7811
Advantage
57
Wuhan Kemi-Works Chemical Co., Ltd
Tel
027-85736489
Fax
86-27-85736485
Email
info@kemiworks.net
Country
China
ProdList
540
Advantage
57
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View Lastest Price from Cloquintocet-mexyl manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Cloquintocet-mexyl 99607-70-2
Price
US $30.00/g
Min. Order
1g
Purity
98%
Supply Ability
2000kg
Release date
2024-03-26
Hebei Yanxi Chemical Co., Ltd.
Product
cloquintocet-mexyl 99607-70-2
Price
US $50.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20tons
Release date
2023-09-05
Hebei Weibang Biotechnology Co., Ltd
Product
Cloquintocet-mexyl 99607-70-2
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24

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