1-N-Cbz-belta-Proline
- Product Name
- 1-N-Cbz-belta-Proline
- CAS No.
- 188527-21-1
- Chemical Name
- 1-N-Cbz-belta-Proline
- Synonyms
- C67154;1-N-CBZ-BETA-PROLINE;1-N-CBZ-BELTA-PROLINE;3-CARBOXY-1-CBZ-PYRROLIDINE;1-Cbz-pyrrolidine-3-carbo...;1-(Benzyloxycarbonyl)pyrrolidi;N-Cbz-3-pyrrolidinecarboxylicacid;1-Cbz-3-pyrrolidinecarboxylic acid;1-Cbz-pyrrolidine-3-carboxylic acid;N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
- CBNumber
- CB3244726
- Molecular Formula
- C13H15NO4
- Formula Weight
- 249.26
- MOL File
- 188527-21-1.mol
1-N-Cbz-belta-Proline Property
- Boiling point:
- 432.3±45.0 °C(Predicted)
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 4.46±0.20(Predicted)
- form
- Solid
- Appearance
- White to off-white Solid
- CAS DataBase Reference
- 188527-21-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- B287195
- Product name
- 1-(Benzyloxycarbonyl)pyrrolidine-3-carboxylicAcid
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- B287195
- Product name
- 1-(Benzyloxycarbonyl)pyrrolidine-3-carboxylicAcid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FB142975
- Product name
- 1-((Benzyloxy)carbonyl)pyrrolidine-3-carboxylic acid
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 4H58-1-WH
- Product name
- 1-[(Benzyloxy)carbonyl]pyrrolidine-3-carboxylic acid
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- W4063
- Product name
- 1-N-CBZ-PYRROLIDINE-3-CARBOXYLICACID
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
1-N-Cbz-belta-Proline Chemical Properties,Usage,Production
Uses
1-?(Benzyloxycarbonyl)?pyrrolidine-?3-?carboxylic Acid is a reagent used in the synthesis of cyclin-dependent kinase 4-inhibitors (CDK4) for cancer treatments. Also used towards the discovery of a potent inhibitor of poly(ADP-ribose) polymerase (PARP) for the treatment of cancer pased upon benzimidazole carboxamide moieties.
Synthesis
188847-00-9
188527-21-1
To a 250 mL multi-necked round-bottomed flask was added 8.1 g (30.8 mmol) of 1-benzyl 3-methylpyrrolidine-1,3-dicarboxylate and 80 mL of tetrahydrofuran, and 80 mL of an aqueous solution of lithium hydroxide of 3.9 g (92.4 mmol) was added slowly dropwise.The reaction mixture was stirred for 1 hr at 0 °C, followed by stirring at room temperature overnight. Upon completion of the reaction, the mixture was washed with ether and the pH of the mixture was adjusted to 5-6 with 0.5 M hydrochloric acid. the mixture was extracted three times with 30 mL of ethyl acetate, and the organic phases were combined. The organic phase was dried with anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure to give 7.3 g of 1-Cbz-3-pyrrolidinecarboxylic acid as a yellow oil in 95% yield.
References
[1] Patent: CN104817549, 2017, B. Location in patent: Paragraph 0044-0046
1-N-Cbz-belta-Proline Preparation Products And Raw materials
Raw materials
Preparation Products
1-N-Cbz-belta-Proline Suppliers
- Tel
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- Fax
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
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- vernam@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
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- Tel
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- Fax
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- enquiries@fluorochem.co.uk
- Country
- United Kingdom
- ProdList
- 6401
- Advantage
- 74
View Lastest Price from 1-N-Cbz-belta-Proline manufacturers
- Product
- 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID 188527-21-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-13