ChemicalBook > CAS DataBase List > N-ACRYLOXYSUCCINIMIDE

N-ACRYLOXYSUCCINIMIDE

Product Name
N-ACRYLOXYSUCCINIMIDE
CAS No.
38862-24-7
Chemical Name
N-ACRYLOXYSUCCINIMIDE
Synonyms
AKOS MSC-0123;N-ACRYLOXYSUCCINIMIDE;N-succinimidyl acrylate;N-Acryloyloxysuccinimide;N-Acryloxysuccinimide,99%;N-(Acryloyloxy)succinimide;N-Acryloxysuccinimide (NAS);N-Succinimidyl Acrylate >N-AcryloxysucciniMide, 99% 1GR;N-AcryloxysucciniMide, 99% 5GR
CBNumber
CB3245051
Molecular Formula
C7H7NO4
Formula Weight
169.13
MOL File
38862-24-7.mol
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N-ACRYLOXYSUCCINIMIDE Property

Melting point:
69 °C
Boiling point:
298.4°C (rough estimate)
Density 
1.4523 (rough estimate)
refractive index 
1.5500 (estimate)
storage temp. 
2-8°C
solubility 
soluble in Toluene
form 
Crystals and Chunks
color 
Yellow
InChI
InChI=1S/C7H7NO4/c1-2-7(11)12-8-5(9)3-4-6(8)10/h2H,1,3-4H2
InChIKey
YXMISKNUHHOXFT-UHFFFAOYSA-N
SMILES
C(ON1C(=O)CCC1=O)(=O)C=C
CAS DataBase Reference
38862-24-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-40-48/20/22-36-22
Safety Statements 
36-26-37/39
WGK Germany 
2
HS Code 
29251900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
A8060
Product name
Acrylic acid N-hydroxysuccinimide ester
Purity
≥90%
Packaging
1g
Price
$115
Updated
2025/07/31
TCI Chemical
Product number
S0814
Product name
N-Succinimidyl Acrylate
Purity
>98.0%(GC)
Packaging
5g
Price
$179
Updated
2025/07/31
TCI Chemical
Product number
S0814
Product name
N-Succinimidyl Acrylate
Purity
>98.0%(GC)
Packaging
25g
Price
$620
Updated
2025/07/31
TRC
Product number
D487113
Product name
2,5-Dioxopyrrolidin-1-ylAcrylate
Packaging
5g
Price
$80
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD139741
Product name
2,5-Dioxopyrrolidin-1-yl acrylate
Packaging
1g
Price
$124
Updated
2021/12/16
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N-ACRYLOXYSUCCINIMIDE Chemical Properties,Usage,Production

Chemical Properties

yellow crystals and chunks

Uses

sulfhydryl reactive cross-linking reagent affording sulfides and HI, can subsequently be radio-iodinated, the phenylazide function can then be photo-activated with long wavelength UV light to couple with another molecule

Uses

Acrylic acid N-hydroxysuccinimide ester (NAS) is a general acrylating agent that is used in the synthesis of:

  • Acrylated hyaluronic acid (HA) hydrogel for bone regeneration applications.
  • Injectable, biodegradable, and thermosensitive copolymers for tissue engineering.
  • Imidazole-based biocompatible, aqueous quantum dots (QDs).

Synthesis

6066-82-6

814-68-6

38862-24-7

N-hydroxysuccinimide (10 g, 0.086 mol) and triethylamine (13.2 g, 0.129 mol) were dissolved in chloroform (130 mL) at 0 °C. Stirring was maintained and acryloyl chloride (8.6 g, 0.094 mol) was slowly added dropwise to the reaction mixture, the dropwise process was controlled to be completed within 2 hours. After the reaction was completed, stirring was continued at 0 °C for 30 min. Subsequently, the reaction solution was washed twice with 60 mL of saturated aqueous NaCl, and the organic phase was dried with MgSO4, filtered and concentrated to a residual volume of about 30 mL. to the concentrate was added a solvent mixture of ethyl acetate/pentane (14 mL, 1:3, v/v/v), and the mixture was kept at 0 °C to promote the crystallization of N-acryloyloxysuccinimide overnight, resulting in the target 70% yield of the Product. The structure of the product was confirmed by 1H NMR (CDCl3) with chemical shifts of 2.95 (s, 4H, CH2CH2), 6.20 (m, 1H, CH=CH2), 6.4 (m, 1H, CH=CH2) and 6.75 (m, 1H, CH=CH2), respectively.

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 10, p. 4528 - 4560
[2] Chemical Communications, 2014, vol. 50, # 95, p. 15045 - 15048
[3] Organic Letters, 2002, vol. 4, # 5, p. 737 - 740
[4] Chemical Communications, 2009, # 46, p. 7107 - 7109
[5] Journal of Medicinal Chemistry, 1995, vol. 38, # 21, p. 4179 - 4190

N-ACRYLOXYSUCCINIMIDE Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide Acetone Sodium sulfate Acryloyl chloride Chloroform Diphenyl chlorophosphate Acrylic acid Sodium bicarbonate Diisopropyl ether

Preparation Products

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N-ACRYLOXYSUCCINIMIDE Suppliers

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View Lastest Price from N-ACRYLOXYSUCCINIMIDE manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
N-ACRYLOXYSUCCINIMIDE 38862-24-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
N-ACRYLOXYSUCCINIMIDE 38862-24-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08
Career Henan Chemical Co
Product
N-ACRYLOXYSUCCINIMIDE 38862-24-7
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
200KG
Release date
2019-08-30

38862-24-7, N-ACRYLOXYSUCCINIMIDERelated Search:

Phthalimidoacetone poly(N-isopropylacrylamide-N-n-butylacrylamide-N-acryloxysuccinimide) poly(N-isopropylacrylamide-co-N-acryloxysuccinimide-co-2-hydroxyethyl methacrylate) 2,2,5,5-TETRAMETHYL-3-PYRROLIN-1-OXYL-3-CARBOXYLIC ACID N-HYDROXYSUCCINIMIDE ESTER AURORA 7119 N-ACRYLOXYSUCCINIMIDE (2,5-Dioxopyrrolidin-1-yl) 2-oxochromene-3-carboxylate 3-(2-FURYL)ACRYLIC ACID*N-HYDROXYSUCCINI MIDE ESTER 7-HYDROXYCOUMARIN-3-CARBOXYLIC ACID N-SUCCINIMIDYL ESTER 7-DIETHYLAMINOCOUMARIN-3-CARBOXYLIC ACID, SUCCINIMIDYL ESTER 1-ACETYL-2,2,5,5-TETRAMETHYL-3-PYRROLINE-3-CARBOXYLIC ACID, N-HYDROXYSUCCINIMIDE ESTER (E)-5-[2-(2-CARBOXYVINYL)]-2'-DEOXYURIDINE N-HYDROXY-SUCCIMIDE ESTER CCVJ-NHS ESTER N-SUCCINIMIDYL 7-METHOXYCOUMARIN-3-CARBOXYLATE

  • N-ACRYLOXYSUCCINIMIDE
  • ACRYLIC ACID N-HYDROXY-SUCCINIMIDE ESTER
  • AKOS MSC-0123
  • 1-[(1-OXO-2-PROPENYL)OXY]-2,5-PYRROLIDINEDIONE
  • 1-(ACRYLOYLOXY)-2,5-PYRROLIDINEDIONE
  • N-Acryloxysuccinimide (NAS)
  • N-succinimidyl acrylate
  • Acrylic acid 2,5-dioxo-1-pyrrolidinyl ester
  • Acrylic acid 2,5-dioxopyrrolidine-1-yl ester
  • Acrylic acid 2,5-dioxopyrrolizino
  • N-(Acryloyloxy)succinimide
  • N-Acryloyloxysuccinimide
  • N-Acryloxysuccinimide,99%
  • N-AcryloxysucciniMide, 99% 1GR
  • N-AcryloxysucciniMide, 99% 5GR
  • 2-propenoic acid (2,5-dioxo-1-pyrrolidinyl) ester
  • 2,5-Dioxo-1-pyrrolidinyl Acrylate
  • Acrylic Acid N-Succinimidyl Ester N-Acryloyloxysuccinimide
  • 2,5-Dioxopyrrolidin-1-yl acrylate
  • Acrylic acid N-hydroxysucciniMide ester >=90%
  • <i>N</i>-Succinimidyl Acrylate
  • N-Succinimidyl Acrylate &gt
  • Acrylic Acid N-Succinimidyl Ester
  • Acrylic acid N-hydroxysuccinimide ester,0.98
  • Acrylic acid <i>N</i>-hydroxysuccinimide ester
  • 38862-24-7
  • Active Esters/Additives
  • Coupling
  • Synthetic Reagents