N-ACRYLOXYSUCCINIMIDE
- Product Name
- N-ACRYLOXYSUCCINIMIDE
- CAS No.
- 38862-24-7
- Chemical Name
- N-ACRYLOXYSUCCINIMIDE
- Synonyms
- AKOS MSC-0123;N-ACRYLOXYSUCCINIMIDE;N-succinimidyl acrylate;N-Acryloyloxysuccinimide;N-Acryloxysuccinimide,99%;N-(Acryloyloxy)succinimide;N-Acryloxysuccinimide (NAS);N-Succinimidyl Acrylate >N-AcryloxysucciniMide, 99% 1GR;N-AcryloxysucciniMide, 99% 5GR
- CBNumber
- CB3245051
- Molecular Formula
- C7H7NO4
- Formula Weight
- 169.13
- MOL File
- 38862-24-7.mol
N-ACRYLOXYSUCCINIMIDE Property
- Melting point:
- 69 °C
- Boiling point:
- 298.4°C (rough estimate)
- Density
- 1.4523 (rough estimate)
- refractive index
- 1.5500 (estimate)
- storage temp.
- 2-8°C
- solubility
- soluble in Toluene
- form
- Crystals and Chunks
- color
- Yellow
- InChI
- InChI=1S/C7H7NO4/c1-2-7(11)12-8-5(9)3-4-6(8)10/h2H,1,3-4H2
- InChIKey
- YXMISKNUHHOXFT-UHFFFAOYSA-N
- SMILES
- C(ON1C(=O)CCC1=O)(=O)C=C
- CAS DataBase Reference
- 38862-24-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-40-48/20/22-36-22
- Safety Statements
- 36-26-37/39
- WGK Germany
- 2
- HS Code
- 29251900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A8060
- Product name
- Acrylic acid N-hydroxysuccinimide ester
- Purity
- ≥90%
- Packaging
- 1g
- Price
- $115
- Updated
- 2025/07/31
- Product number
- S0814
- Product name
- N-Succinimidyl Acrylate
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- S0814
- Product name
- N-Succinimidyl Acrylate
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $620
- Updated
- 2025/07/31
- Product number
- D487113
- Product name
- 2,5-Dioxopyrrolidin-1-ylAcrylate
- Packaging
- 5g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- FD139741
- Product name
- 2,5-Dioxopyrrolidin-1-yl acrylate
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
N-ACRYLOXYSUCCINIMIDE Chemical Properties,Usage,Production
Chemical Properties
yellow crystals and chunks
Uses
sulfhydryl reactive cross-linking reagent affording sulfides and HI, can subsequently be radio-iodinated, the phenylazide function can then be photo-activated with long wavelength UV light to couple with another molecule
Uses
Acrylic acid N-hydroxysuccinimide ester (NAS) is a general acrylating agent that is used in the synthesis of:
- Acrylated hyaluronic acid (HA) hydrogel for bone regeneration applications.
- Injectable, biodegradable, and thermosensitive copolymers for tissue engineering.
- Imidazole-based biocompatible, aqueous quantum dots (QDs).
Synthesis
6066-82-6
814-68-6
38862-24-7
N-hydroxysuccinimide (10 g, 0.086 mol) and triethylamine (13.2 g, 0.129 mol) were dissolved in chloroform (130 mL) at 0 °C. Stirring was maintained and acryloyl chloride (8.6 g, 0.094 mol) was slowly added dropwise to the reaction mixture, the dropwise process was controlled to be completed within 2 hours. After the reaction was completed, stirring was continued at 0 °C for 30 min. Subsequently, the reaction solution was washed twice with 60 mL of saturated aqueous NaCl, and the organic phase was dried with MgSO4, filtered and concentrated to a residual volume of about 30 mL. to the concentrate was added a solvent mixture of ethyl acetate/pentane (14 mL, 1:3, v/v/v), and the mixture was kept at 0 °C to promote the crystallization of N-acryloyloxysuccinimide overnight, resulting in the target 70% yield of the Product. The structure of the product was confirmed by 1H NMR (CDCl3) with chemical shifts of 2.95 (s, 4H, CH2CH2), 6.20 (m, 1H, CH=CH2), 6.4 (m, 1H, CH=CH2) and 6.75 (m, 1H, CH=CH2), respectively.
References
[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 10, p. 4528 - 4560
[2] Chemical Communications, 2014, vol. 50, # 95, p. 15045 - 15048
[3] Organic Letters, 2002, vol. 4, # 5, p. 737 - 740
[4] Chemical Communications, 2009, # 46, p. 7107 - 7109
[5] Journal of Medicinal Chemistry, 1995, vol. 38, # 21, p. 4179 - 4190
N-ACRYLOXYSUCCINIMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-ACRYLOXYSUCCINIMIDE Suppliers
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View Lastest Price from N-ACRYLOXYSUCCINIMIDE manufacturers
- Product
- N-ACRYLOXYSUCCINIMIDE 38862-24-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- N-ACRYLOXYSUCCINIMIDE 38862-24-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- N-ACRYLOXYSUCCINIMIDE 38862-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 200KG
- Release date
- 2019-08-30