ChemicalBook > CAS DataBase List > 3-Thiophenecarbonitrile

3-Thiophenecarbonitrile

Product Name
3-Thiophenecarbonitrile
CAS No.
1641-09-4
Chemical Name
3-Thiophenecarbonitrile
Synonyms
THIOPHENE-3-CARBONITRILE;3-cyanothiophen;3-CYANOTHIOPHENE;BUTTPARK 96\11-31;3-Thiophenecarbonitr;3-Cyanothiophene >3-THIOPHENECARBONITRILE;Thiophen-3-carbonitrile;3-Thiophenecarbonitrile 95%;3-Thiophenecarbonitrile,94%
CBNumber
CB3245804
Molecular Formula
C5H3NS
Formula Weight
109.15
MOL File
1641-09-4.mol
More
Less

3-Thiophenecarbonitrile Property

Boiling point:
82 °C10 mm Hg(lit.)
Density 
1.2 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5630(lit.)
Flash point:
186 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
Liquid
Specific Gravity
1.2
color 
Clear colorless
BRN 
107104
CAS DataBase Reference
1641-09-4(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-36/37
RIDADR 
3276
WGK Germany 
3
Hazard Note 
Harmful
HazardClass 
6.1
PackingGroup 
III
HS Code 
29341000
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
597449
Product name
3-Thiophenecarbonitrile
Purity
95%
Packaging
5g
Price
$36.7
Updated
2025/07/31
Sigma-Aldrich
Product number
597449
Product name
3-Thiophenecarbonitrile
Purity
95%
Packaging
25g
Price
$156
Updated
2025/07/31
TCI Chemical
Product number
C1344
Product name
3-Cyanothiophene
Purity
>98.0%(GC)
Packaging
5g
Price
$48
Updated
2025/07/31
TCI Chemical
Product number
C1344
Product name
3-Cyanothiophene
Purity
>98.0%(GC)
Packaging
25g
Price
$192
Updated
2025/07/31
Usbiological
Product number
291449
Product name
Thiophene-3-carbonitrile
Packaging
10g
Price
$337
Updated
2021/12/16
More
Less

3-Thiophenecarbonitrile Chemical Properties,Usage,Production

Chemical Properties

Clear colorless liquid

Uses

3-Thiophenecarbonitrile can be used to synthesize the following:

  • 2,4-dinaphthyl-3-cyanothiophene via reaction with iodonaphthalene
  • 2,5-bis-tri(n-butyl)tin-3-cyanothiophene, a building block for the synthesis of new alternating (3-alkyl/3-cyano)thiophene copolymers

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 1670, 1979 DOI: 10.1021/jo01324a019
Synthetic Communications, 20, p. 3153, 1990 DOI: 10.1080/00397919008051539

Synthesis

498-62-4

1641-09-4

General procedure for the synthesis of 3-cyanothiophene from 3-thiophenecarboxaldehyde: A mixture of 3-thiophenecarboxaldehyde (1.0 mmol), NH2OH-HCl (1.5 mmol), and Cog-C3N4 (20 mg) in H2O/MeOH (1:1, 5 mL) was added to a round-bottomed flask and the reaction was stirred for 14-20 h at room temperature under visible-light irradiation. The reaction progress was monitored by TLC. After completion of the reaction, the catalyst was removed by filtration and the filtrate was extracted by adding EtOAc (10 mL) to the filtrate. The organic layer was separated and washed sequentially with brine (2 x 5 mL) and distilled water (1 x 10 mL) and then dried with anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give the crude product. The crude product was further purified by fast column chromatography with the eluent ratio of EtOAc/hexane (10:90) to obtain analytically pure 3-cyanothiophene.

References

[1] Organic Letters, 2017, vol. 19, # 11, p. 3005 - 3008
[2] Catalysis Communications, 2019, p. 76 - 81
[3] Journal of Polymer Science, Part A: Polymer Chemistry, 2014, vol. 52, # 8, p. 1055 - 1058
[4] Tetrahedron Letters, 2012, vol. 53, # 7, p. 882 - 885
[5] Chemical Communications, 2013, vol. 49, # 54, p. 6030 - 6032

3-Thiophenecarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

3-Thiophenecarbonitrile Suppliers

Americas 1 Belgium 3 Canada 1 CHINA 144 Europe 3 France 1 Germany 8 India 19 Japan 4 Slovakia 1 Switzerland 3 United Kingdom 22 United States 42 Global 252
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Wuhan Chemwish Technology Co., Ltd
Tel
86-027-67849912
Fax
86-027-87531808
Email
sales@chemwish.com
Country
China
ProdList
35896
Advantage
56
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Country
China
ProdList
18207
Advantage
66
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9310
Advantage
66
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Country
China
ProdList
5691
Advantage
66
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527621225
Email
1791901229@qq.com
Country
China
ProdList
6946
Advantage
52
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11707
Advantage
57
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
Email
sales@topbiochem.com
Country
China
ProdList
6175
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66113011 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19913
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai joygo pharmacetical tech., Co., Ltd.
Tel
13621615409
Fax
QQ:3065286126, 1796903118
Email
sale1@joygooo.com
Country
China
ProdList
108
Advantage
50
Shanghai Jovan Biochemical Technology Co. Ltd.
Tel
+86-021-61654350
Fax
+86-021-61654350
Email
1245958370@qq.com
Country
China
ProdList
2982
Advantage
50
Shanghai Song Yuan Chemical Technology Co., Ltd.
Tel
010-1234567 18521000990
Fax
86-021-33275113
Email
sonyuanchemical@163.com
Country
China
ProdList
6479
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Hangzhou Milestone Pharmtech Co., Ltd.
Tel
0571-82896630 18969958410
Email
sales_hz@milestonepharmtech.com
Country
China
ProdList
4894
Advantage
55
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51395
Advantage
80
Giant chemicals
Tel
028-85434334 18108076537
Fax
QQ：245797092
Email
market@gianthx.com
Country
China
ProdList
4505
Advantage
56
Nanjing Vital Chemical Co., Ltd.
Tel
025-87193546 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
9021
Advantage
60
Henan CoreyChem Co., Ltd
Tel
0371-86658258
Fax
0371-60996044
Email
info@coreychem.com
Country
China
ProdList
10453
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shandong Xiya Chemical Co., Ltd.
Tel
4009903999 13395398332
Fax
0539-6365991
Email
sales@xiyashiji.com
Country
China
ProdList
20794
Advantage
60
Zhengzhou AnMusi Chemical Products Co., Ltd.
Tel
0371-55289822 18737195735
Fax
QQ：2370407954
Email
2370407954@qq.com
Country
China
ProdList
1981
Advantage
55
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Taian Jiaye Biotechnology Co.Ltd
Tel
13127280945
Email
285424065@qq.com
Country
China
ProdList
9976
Advantage
55
Shandong Ono Chemical Co., Ltd.
Tel
0539-6362799 20）
Fax
0539-6362799（To 20）
Country
China
ProdList
9998
Advantage
58
Shanghai Darui Fine Chemicals Co., Ltd.
Tel
021-33922791-0 13816046603
Email
3368239663@qq.com
Country
China
ProdList
4287
Advantage
58
9ding chemical ( Shanghai) Limited
Tel
021-021-52271985 17721149837
Fax
+86 (21) 52271987
Email
sales@9dingchem.com
Country
China
ProdList
19800
Advantage
60
Zhengzhou JACS Chemical Co., Ltd.
Tel
0371-0371-86259281 15981966935
Fax
0371-86259281
Email
jacschem@163.com
Country
China
ProdList
2005
Advantage
58
Capot Chemical Co.,Ltd.
Tel
+86-（0）57185586718; +8613336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29735
Advantage
60
Wuhan FengyaoTonghui Chemical Products Co., Ltd.
Tel
027-87466105 15377573527
Email
2678564200@qq.com
Country
China
ProdList
17987
Advantage
58
Nanjing NingFan Pharm-Tech CO. LTD.
Tel
17368696818
Country
China
ProdList
1984
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Zhengzhou Ruke Biological Co., Ltd.
Tel
15981811963
Fax
QQ：1410472904
Email
1410472904@qq.com
Country
China
ProdList
5825
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
3A Chemicals
Tel
400-668-9898
Fax
010-51582189
Email
service@3achem.com
Country
China
ProdList
20557
Advantage
58
Nanjing holy chemical co., LTD
Tel
19951936396
Email
1815156226@qq.com
Country
China
ProdList
2947
Advantage
58
More
Less

View Lastest Price from 3-Thiophenecarbonitrile manufacturers

Shenzhen Nexcon Pharmatechs Ltd.
Product
3-Thiophenecarbonitrile 1641-09-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
2000
Release date
2025-04-18
R&D Scientific Inc.
Product
3-Thiophenecarbonitrile 1641-09-4
Price
US $1786.00/Kg
Min. Order
1Kg
Purity
99 %
Supply Ability
1000 Kg
Release date
2024-11-12
Career Henan Chemical Co
Product
3-Thiophenecarbonitrile 1641-09-4
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
150KG
Release date
2019-08-05

1641-09-4, 3-ThiophenecarbonitrileRelated Search:

Tetrahydrothiophene ETHYL 2-CYANOACRYLATE Benzonitrile Methylene dithiocyanate Cyanoacetic acid Thifensulfuron Thiophene Thifensulfuron methyl Poly(3-hexylthiophene-2,5-diyl) Cephalothin sodium Sodium cyanoborohydride 4-Nitrobenzonitrile 2-NITROTHIOPHENE-4-CARBONITRILE N1-(3-CYANO-4-METHYL-2-THIENYL)-2-CHLOROACETAMIDE 2-AMINO-4,5-TRIMETHYLENE-3-THIOPHENECARBONITRILE METHYL 3-AMINO-4-CYANOTHIOPHENE-2-CARBOXYLATE 2-Thiophenecarbonitrile ETHYL 3-AMINO-4-CYANO-5-(METHYLTHIO)THIOPHENE-2-CARBOXYLATE

  • BUTTPARK 96\11-31
  • 3-CYANOTHIOPHENE
  • 3-THIOPHENECARBONITRILE
  • THIOPHENE-3-CARBONITRILE
  • Thiophene-3-carbonitrile 97%
  • 3-Thiophenecarbonitr
  • 3-Cyanothiophene, Thiophene-3-nitrile
  • 3-Thiophenecarbonitrile,94%
  • 3-cyanothiophen
  • 3-Thiophenecarbonitrile 95%
  • 3-thiophenecarbonitrile:3-cyanothiophene
  • 3-Cyanothiophene &gt
  • 3-Thiophenecarbonitrile ISO 9001：2015 REACH
  • 3-Thiophenecarbonitrile (6CI, 7CI, 8CI, 9CI, ACI)
  • Thiophen-3-carbonitrile
  • 1641-09-4
  • 1641-09-0
  • C5H3NS
  • Heterocyclic Building Blocks
  • Thiophenes
  • Thiophene Derivatives (for Conduting Polymer Research)
  • Reagents for Conducting Polymer Research
  • Building Blocks
  • Functional Materials
  • Reagents for Conducting Polymer Research
  • Thiophene Derivatives (for Conduting Polymer Research)
  • Thiophen
  • Sulphur Derivatives
  • Thiophene&Benzothiophene