ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate

Product Name: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
CAS No.: 194673-12-6
Chemical Name: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
Synonyms: 6-oxo-2-(trifL;Ethyl 6-oxo-2-(trifluoromethyl);)-1,4,5,6-tetrahydro-3-pyridinecarboxyL;-1,4,5,6-tetrahydropyridine-3-carboxylate;3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(triflu...;Ethyl 2-oxo-6-(trifluoromethyl)-3,4-dihydro-1h-pyridine-5-carboxylate;ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate;6-Hydroxy-2-trifluoromethyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester;2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyridine-5-carboxylic acid ethyl ester;1,4,5,6-Tetrahydro-6-oxo-2-(trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester
CBNumber: CB32462216
Molecular Formula: C9H10F3NO3
Formula Weight: 237.18
MOL File: 194673-12-6.mol

More

Less

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Property

Melting point:: 128～130℃
Boiling point:: 294℃
Density: 1.351
Flash point:: 132℃
storage temp.: Sealed in dry,Room Temperature
pka: 11.80±0.60(Predicted)
Appearance: Off-white to light yellow Solid

More

Less

Safety

HS Code: 2933399990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

More

Less

N-Bromosuccinimide Price

TRC

Product number: E926528
Product name: Ethyl6-Oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 043511
Product name: Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
Purity: 95+%
Packaging: 1g
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: 6563AD
Product name: Ethyl6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
Packaging: 1g
Price: $158
Updated: 2021/12/16

Matrix Scientific

Product number: 043511
Product name: Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
Purity: 95+%
Packaging: 5g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: PC4906
Product name: Ethyl6-oxo-1,4,5,6-tetrahydro-2-(trifluoromethyl)pyridine-3-carboxylate
Packaging: 1g
Price: $385
Updated: 2021/12/16

More

Less

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

79-06-1

372-31-6

194673-12-6

GENERAL STEPS: A mixture of ethyl 4,4,4-trifluoroacetoacetate (14.7 mL, 0.1 mol, 1.6 eq.), acrylamide (4.5 g, 0.063 mol, 1.0 eq.), and p-toluene sulfonate (0.156 g, 0.82 mmol, 0.013 eq.) in toluene (60 mL) was refluxed in a Dean-Stark device for for 38 hours to azeotropically remove the resulting water. Upon completion of the reaction, most of the toluene was removed by slow distillation at atmospheric pressure and the reaction mixture was concentrated to a smaller volume. Toluene (60 mL) was added again to the concentrated mixture and the distillation and concentration process was repeated as described above. This operation was performed three times. Finally, the reaction mixture was further concentrated under vacuum and the resulting solid residue was purified by fast column chromatography (silica gel as stationary phase, eluent gradient: from hexane/ethyl acetate 9:1 to hexane/ethyl acetate 8:2). Purification afforded the target compound ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate as a brown solid (3.8 g, 25% yield). The product was analyzed by LC-MS (ESI+) and showed molecular ion peaks MH+: 238, 210, 190.

References

[1] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 40; 44
[2] Patent: WO2004/29026, 2004, A1. Location in patent: Page 33-34
[3] Patent: WO2004/29027, 2004, A1. Location in patent: Page 30

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Suppliers

China 35 India 1 United Kingdom 2 United States 5 Global 43

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Shijiazhuang Sdyano Fine Chemical Co., Ltd.

Tel: 0311-89250318 031166536426
Fax: 4000311741
Email: master@sjzsdyn.com
Country: China
ProdList: 2805
Advantage: 65

Capot Chemical Co., Ltd

Tel: +86 (0) 571 85 58 67 18
Fax: 0086-571-85864795
Country: China
ProdList: 18207
Advantage: 66

Shanghai Xingui Biotechnology Co., Ltd.

Tel: 15121041756
Email: xingui2022@126.com
Country: China
ProdList: 9976
Advantage: 58

Hotechem Shanghai Co., Ltd.,

Tel: 021-34621078 13120882795
Fax: 021-34622517
Email: 465106944@qq.com
Country: China
ProdList: 857
Advantage: 56

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shijiazhuang Yesheng Chemical Technology Co., Ltd

Tel: 18031147013 18031147013;
Fax: 0311-68030586
Email: yeshengchemical@163.com
Country: China
ProdList: 2607
Advantage: 58

Capot Chemical Co.,Ltd.

Tel: +86-（0）57185586718; +8613336195806
Fax: +86-571-85864795
Email: sales@capot.com
Country: China
ProdList: 29735
Advantage: 60

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Nanjing crow LuNing pharmaceutical technology co., LTD

Tel: 13382066392
Country: CHINA
ProdList: 4877
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Allfluoro pharmaceutical co. ltd.

Tel: +86-400-0216110 +86-15958047586
Fax: 0086-21-33275002
Email: sales@allfluoro.com
Country: China
ProdList: 11385
Advantage: 58

ANHUI WITOP BIOTECH CO., LTD

Tel: +8615255079626
Email: eric@witopchemical.com
Country: China
ProdList: 23541
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25356
Advantage: 58

Dideu Industries Group Limited

Tel: +86-29-89586680 +86-15129568250
Email: 1026@dideu.com
Country: China
ProdList: 20284
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Guangdong Wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2886766 13927870850
Fax: 0751-2886756
Email: 3001267247@qq.com
Country: China
ProdList: 9941
Advantage: 58

Chengdu Feibo Pharm Technology Co., Ltd

Tel: +86 028-84641798 15982321820
Email: abby@arkpharm.com
Country: China
ProdList: 10000
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Zhengzhou convergence chemical co., LTD

Tel: 0371-0371-55153829 18003835034
Email: 2853979819@qq.com
Country: China
ProdList: 9998
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Country: China
ProdList: 40000
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 59936
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39665
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Baoji Didu Pharmaceutical and Chemical Co., Ltd

Tel: 029-81145305 17791533577
Email: 1021@dideu.com
Country: China
ProdList: 10009
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

ANHUI BYERSEN BIOTECH CO. LTD

Tel: +86-15385096007 +86-17755058861
Email: amy@byersenchemical.com
Country: China
ProdList: 10000
Advantage: 58

Aromsyn Co., Ltd.

Tel: +86-0571-85585865 +8613336024896
Email: CB@aromsyn.com
Country: China
ProdList: 19183
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

Hangzhou Ocean Chemical Co., Ltd

Tel: --
Fax: --
Email: sales@hzoceanchem.com
Country: China
ProdList: 6101
Advantage: 0

More

Less

View Lastest Price from ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate manufacturers

Dideu Industries Group Limited

Product: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 194673-12-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-28

Career Henan Chemical Co

Product: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 194673-12-6
Price: US $1.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-10

194673-12-6, ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylateRelated Search:

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate

1,4,5,6-Tetrahydro-6-oxo-2-(trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester

6-Hydroxy-2-trifluoromethyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester

-1,4,5,6-tetrahydropyridine-3-carboxylate

Ethyl 6-oxo-2-(trifluoromethyl)

Ethyl 2-oxo-6-(trifluoromethyl)-3,4-dihydro-1h-pyridine-5-carboxylate

3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(trifluoromethyl)-, ethyl ester

2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyridine-5-carboxylic acid ethyl ester

)-1,4,5,6-tetrahydro-3-pyridinecarboxyL

6-oxo-2-(trifL

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate ISO 9001：2015 REACH

3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(triflu...

194673-12-6

Heterocycles