ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
- Product Name
- ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
- CAS No.
- 194673-12-6
- Chemical Name
- ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
- Synonyms
- 6-oxo-2-(trifL;Ethyl 6-oxo-2-(trifluoromethyl);)-1,4,5,6-tetrahydro-3-pyridinecarboxyL;-1,4,5,6-tetrahydropyridine-3-carboxylate;3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(triflu...;Ethyl 2-oxo-6-(trifluoromethyl)-3,4-dihydro-1h-pyridine-5-carboxylate;ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate;6-Hydroxy-2-trifluoromethyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester;2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyridine-5-carboxylic acid ethyl ester;1,4,5,6-Tetrahydro-6-oxo-2-(trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester
- CBNumber
- CB32462216
- Molecular Formula
- C9H10F3NO3
- Formula Weight
- 237.18
- MOL File
- 194673-12-6.mol
ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Property
- Melting point:
- 128～130℃
- Boiling point:
- 294℃
- Density
- 1.351
- Flash point:
- 132℃
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 11.80±0.60(Predicted)
- Appearance
- Off-white to light yellow Solid
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E926528
- Product name
- Ethyl6-Oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 043511
- Product name
- Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 6563AD
- Product name
- Ethyl6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
- Packaging
- 1g
- Price
- $158
- Updated
- 2021/12/16
- Product number
- 043511
- Product name
- Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- PC4906
- Product name
- Ethyl6-oxo-1,4,5,6-tetrahydro-2-(trifluoromethyl)pyridine-3-carboxylate
- Packaging
- 1g
- Price
- $385
- Updated
- 2021/12/16
ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Chemical Properties,Usage,Production
Synthesis
79-06-1
372-31-6
194673-12-6
GENERAL STEPS: A mixture of ethyl 4,4,4-trifluoroacetoacetate (14.7 mL, 0.1 mol, 1.6 eq.), acrylamide (4.5 g, 0.063 mol, 1.0 eq.), and p-toluene sulfonate (0.156 g, 0.82 mmol, 0.013 eq.) in toluene (60 mL) was refluxed in a Dean-Stark device for for 38 hours to azeotropically remove the resulting water. Upon completion of the reaction, most of the toluene was removed by slow distillation at atmospheric pressure and the reaction mixture was concentrated to a smaller volume. Toluene (60 mL) was added again to the concentrated mixture and the distillation and concentration process was repeated as described above. This operation was performed three times. Finally, the reaction mixture was further concentrated under vacuum and the resulting solid residue was purified by fast column chromatography (silica gel as stationary phase, eluent gradient: from hexane/ethyl acetate 9:1 to hexane/ethyl acetate 8:2). Purification afforded the target compound ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate as a brown solid (3.8 g, 25% yield). The product was analyzed by LC-MS (ESI+) and showed molecular ion peaks MH+: 238, 210, 190.
References
[1] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 40; 44
[2] Patent: WO2004/29026, 2004, A1. Location in patent: Page 33-34
[3] Patent: WO2004/29027, 2004, A1. Location in patent: Page 30
ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Suppliers
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View Lastest Price from ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate manufacturers
- Product
- ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 194673-12-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-09-28
- Product
- ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 194673-12-6
- Price
- US $1.00/KG
- Min. Order
- 1g
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-01-10