ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate

Product Name: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
CAS No.: 194673-12-6
Chemical Name: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
Synonyms: 6-oxo-2-(trifL;Ethyl 6-oxo-2-(trifluoromethyl);)-1,4,5,6-tetrahydro-3-pyridinecarboxyL;-1,4,5,6-tetrahydropyridine-3-carboxylate;3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(triflu...;Ethyl 2-oxo-6-(trifluoromethyl)-3,4-dihydro-1h-pyridine-5-carboxylate;ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate;6-Hydroxy-2-trifluoromethyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester;2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyridine-5-carboxylic acid ethyl ester;1,4,5,6-Tetrahydro-6-oxo-2-(trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester
CBNumber: CB32462216
Molecular Formula: C9H10F3NO3
Formula Weight: 237.18
MOL File: 194673-12-6.mol

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ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Property

Melting point:: 128～130℃
Boiling point:: 294℃
Density: 1.351
Flash point:: 132℃
storage temp.: Sealed in dry,Room Temperature
pka: 11.80±0.60(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: E926528
Product name: Ethyl6-Oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 043511
Product name: Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
Purity: 95+%
Packaging: 1g
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: 6563AD
Product name: Ethyl6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
Packaging: 1g
Price: $158
Updated: 2021/12/16

Matrix Scientific

Product number: 043511
Product name: Ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate
Purity: 95+%
Packaging: 5g
Price: $250
Updated: 2021/12/16

Apolloscientific

Product number: PC4906
Product name: Ethyl6-oxo-1,4,5,6-tetrahydro-2-(trifluoromethyl)pyridine-3-carboxylate
Packaging: 1g
Price: $385
Updated: 2021/12/16

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ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Chemical Properties,Usage,Production

Synthesis

79-06-1

372-31-6

194673-12-6

GENERAL STEPS: A mixture of ethyl 4,4,4-trifluoroacetoacetate (14.7 mL, 0.1 mol, 1.6 eq.), acrylamide (4.5 g, 0.063 mol, 1.0 eq.), and p-toluene sulfonate (0.156 g, 0.82 mmol, 0.013 eq.) in toluene (60 mL) was refluxed in a Dean-Stark device for for 38 hours to azeotropically remove the resulting water. Upon completion of the reaction, most of the toluene was removed by slow distillation at atmospheric pressure and the reaction mixture was concentrated to a smaller volume. Toluene (60 mL) was added again to the concentrated mixture and the distillation and concentration process was repeated as described above. This operation was performed three times. Finally, the reaction mixture was further concentrated under vacuum and the resulting solid residue was purified by fast column chromatography (silica gel as stationary phase, eluent gradient: from hexane/ethyl acetate 9:1 to hexane/ethyl acetate 8:2). Purification afforded the target compound ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydro-3-pyridinecarboxylate as a brown solid (3.8 g, 25% yield). The product was analyzed by LC-MS (ESI+) and showed molecular ion peaks MH+: 238, 210, 190.

References

[1] Patent: WO2005/74939, 2005, A1. Location in patent: Page/Page column 40; 44
[2] Patent: WO2004/29026, 2004, A1. Location in patent: Page 33-34
[3] Patent: WO2004/29027, 2004, A1. Location in patent: Page 30

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate manufacturers

Dideu Industries Group Limited

Product: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 194673-12-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-09-28

Career Henan Chemical Co

Product: ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate 194673-12-6
Price: US $1.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-10

194673-12-6, ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylateRelated Search:

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate

1,4,5,6-Tetrahydro-6-oxo-2-(trifluoromethyl)-3-pyridinecarboxylic acid ethyl ester

6-Hydroxy-2-trifluoromethyl-4,5-dihydropyridine-3-carboxylic acid ethyl ester

-1,4,5,6-tetrahydropyridine-3-carboxylate

Ethyl 6-oxo-2-(trifluoromethyl)

Ethyl 2-oxo-6-(trifluoromethyl)-3,4-dihydro-1h-pyridine-5-carboxylate

3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(trifluoromethyl)-, ethyl ester

2-oxo-6-(trifluoromethyl)-3,4-dihydro-1H-pyridine-5-carboxylic acid ethyl ester

)-1,4,5,6-tetrahydro-3-pyridinecarboxyL

6-oxo-2-(trifL

ethyl 6-oxo-2-(trifluoromethyl)-1,4,5,6-tetrahydropyridine-3-carboxylate ISO 9001：2015 REACH

3-Pyridinecarboxylicacid, 1,4,5,6-tetrahydro-6-oxo-2-(triflu...

194673-12-6

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