ChemicalBook > CAS DataBase List > Decursin

Decursin

Product Name: Decursin
CAS No.: 5928-25-6
Chemical Name: Decursin
Synonyms: DECURSIN;Decurson;(S)-(+)-decursin;DECURSIN USP/EP/BP;Decursin - Bio-X ?;DECURSINOL ANGELATE;Decursin ((+)-Decursin);Decursin, 10 mM in DMSO;Decursin (Synonyms: (+)-Decursin);Decursin, 98%, from Angelica decursiva (Miq.) Franch. & Sav.
CBNumber: CB3247101
Molecular Formula: C19H20O5
Formula Weight: 328.36
MOL File: 5928-25-6.mol

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Decursin Property

Melting point:: 93-94℃
Boiling point:: 469.4±45.0 °C(Predicted)
Density: 1.24
storage temp.: -20°C
solubility: DMSO: soluble5mg/mL, clear
form: powder
color: white to beige
biological source: Radix peucedani
optical activity: [α]/D +120 to +160°, c = 0.5 in chloroform-d
InChI: InChI=1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1
InChIKey: CUKSFECWKQBVED-INIZCTEOSA-N
SMILES: C(O[C@@H]1C(C)(C)OC2=C(C1)C=C1C(=C2)OC(=O)C=C1)(=O)/C=C(/C)\C

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0786
Product name: Decursin
Purity: ≥97% (HPLC)
Packaging: 1mg
Price: $110
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0786
Product name: Decursin
Purity: ≥97% (HPLC)
Packaging: 5mg
Price: $437
Updated: 2025/07/31

TCI Chemical

Product number: D6144
Product name: Decursin
Packaging: 25MG
Price: $370
Updated: 2025/07/31

Cayman Chemical

Product number: 25214
Product name: Decursin
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 25214
Product name: Decursin
Purity: ≥98%
Packaging: 5mg
Price: $116
Updated: 2024/03/01

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Decursin Chemical Properties,Usage,Production

Description

Decursin is a phytochemical originally isolated from A. gigas with diverse biological activities. It reduces the growth of B16/F10 murine melanoma cells, but not NIH-3T3 fibroblasts, via induction of apoptosis and increased caspase-3 activity when used at concentrations ranging from 40 to 100 μM. In vivo, decursin (10 mg/kg, i.p.) reduces tumor growth in a B16/F10 mouse xenograft model. Decursin inhibits RANKL-induced osteoclast differentiation and decreases fusion and migrations of pre-osteoclasts in vitro and prevents LPS-induced bone erosion in mice. In a mouse model of seizures induced by kainic acid , decursin (20 mg/kg) increases latency to the first electroencephalographic (EEG) discharge and attenuates the intensity and reduces the frequency of seizure discharges in the parietal cortex. Decursin inhibits tube formation and expression of VEGF receptor 2 (VEGFR2) in human retinal microvascular endothelial cells (HRMECs) and human umbilical vein endothelial cells (HUVECs) in vitro and reduces retinal expression of VEGFR2 and neovascularization in rats with diabetes induced by streptozotocin . It also reduces hepatic collagen expression, serum levels of ALT, AST, and ALP, and production of reactive oxygen species (ROS) in a mouse model of CCL₄-induced liver fibrosis.

Chemical Properties

It is soluble in organic solvents such as methanol, ethanol, and DMSO, and is derived from Angelica sinensis and Peucedanum purpurogenum.

Uses

Decursin is a bioactive metabolites from the root of Angelica gigas Nakai which exhibits neuro-protective and cognitive enhancement effects. Human monoamine oxidase (MAO) inhibitor. Also, it could be useful for the treatment of bone associated with excessive bone resorption.

Definition

ChEBI: Decursin is a member of coumarins.

Biochem/physiol Actions

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.

Side effects

It is important to note that Decursin has not been approved by the FDA for any medical use and there is limited research on its safety and effectiveness. Possible side effects of Decursin include nausea, vomiting, diarrhea, abdominal pain, dizziness, headache, and rash. It may also interact with certain medications, so it is important to consult with a healthcare professional before taking Decursin. Additionally, Decursin may not be safe for pregnant or breastfeeding women, as well as those with certain medical conditions.

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References

[1] BYUNG SOO KIM. Decursin from Angelica gigas Nakai Inhibits B16F10 Melanoma Growth Through Induction of Apoptosis.[J]. Journal of medicinal food, 2015, 18 10: 1121-1127. DOI: 10.1089/jmf.2014.3397
[2] KWANG-JIN KIM . Decursin inhibits osteoclastogenesis by downregulating NFATc1 and blocking fusion of pre-osteoclasts[J]. Bone, 2015, 81: Pages 208-216. DOI: 10.1016/j.bone.2015.07.023
[3] JONG-KEUN LEE. Decursin attenuates kainic acid-induced seizures in mice.[J]. Neuroreport, 2014, 25 16: 1243-1249. DOI: 10.1097/wnr.0000000000000208
[4] YING YANG . Decursin inhibited proliferation and angiogenesis of endothelial cells to suppress diabetic retinopathy via VEGFR2[J]. Molecular and Cellular Endocrinology, 2013, 378 1: Pages 46-52. DOI: 10.1016/j.mce.2013.04.021
[5] YOUNG JI CHOI. Decursin attenuates hepatic fibrogenesis through interrupting TGF-beta-mediated NAD(P)H oxidase activation and Smad signaling in vivo and in vitro[J]. Life sciences, 2014, 108 2: Pages 94-103. DOI: 10.1016/j.lfs.2014.05.012

Decursin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Decursin manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Decursin 5928-25-6
Price: US $0.00/mg
Min. Order: 20mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-04-21

Career Henan Chemical Co

Product: Decursin 5928-25-6
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

5928-25-6, DecursinRelated Search:

Taxuspine X taxiphyllin PolyphyllinH 2'-O-Methylkurarinone Monnieriside G Protodeltonin Decursinol VIOMELLEIN Decuroside I Decursitin D Purpureagitoside deacetyllanatoside A VIOLURIC ACID DECURSINOL ANGELATE DECURSIN(RG) 4-tert-Butoxystyrene 2-PHENOXYETHYL ACRYLATE 4-(2-ACETOXYETHOXY)TOLUENE

DECURSIN

DECURSINOL ANGELATE

(7S)-7,8-Dihydro-8,8-dimethyl-7-[(3-methyl-2-butenoyl)oxy]-2H,6H-benzo[1,2-b:5,4-b']dipyran-2-one

3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester

3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester

(7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate

(S)-(+)-decursin

Decursin, 98%, from Angelica decursiva (Miq.) Franch. & Sav.

3-methyl-2-butenoic acid (2,2-dimethyl-8-oxo-3,4-dihydropyrano[3,2-g][1]benzopyran-3-yl) ester

Decursin ((+)-Decursin)

Decursin (Synonyms: (+)-Decursin)

Decurson

2-Butenoic acid, 3-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester

DECURSIN USP/EP/BP

(S)-2,2-dimethyl-8-oxo-2,3,4,8-tetrahydropyrano[3,2-g]chromen-3-yl 3-methylbut-2-enoate

(S)-8,8-Dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl 3-methylbut-2-enoate

Decursin, 10 mM in DMSO

Decursin - Bio-X ?

5928-25-6

C19H20O5

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